Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human immunodeficiency virus 1 | Integrase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | hypothetical protein | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Plasmodium yoelii | integrase-related | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma congolense | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Trypanosoma brucei | RNA helicase, putative | Get druggable targets OG5_139608 | All targets in OG5_139608 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | hypothetical protein | 0.0064 | 0 | 0.5 |
Echinococcus granulosus | carbonic anhydrase II | 0.0173 | 1 | 1 |
Loa Loa (eye worm) | CAMK/CAMKL/CHK1 protein kinase | 0.0172 | 0.9886 | 0.9886 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0115 | 0.4675 | 0.4675 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0173 | 1 | 1 |
Echinococcus multilocularis | serine:threonine protein kinase Chk2 | 0.0115 | 0.4675 | 0.4675 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0173 | 1 | 0.5 |
Plasmodium falciparum | carbonic anhydrase | 0.0064 | 0 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0173 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0115 | 0.4675 | 0.5 |
Echinococcus granulosus | serine:threonine protein kinase Chk2 | 0.0115 | 0.4675 | 0.4675 |
Brugia malayi | Protein kinase domain containing protein | 0.0172 | 0.9886 | 0.9886 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0173 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0115 | 0.4675 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0173 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0173 | 1 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0173 | 1 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0173 | 1 | 1 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase I | 0.0115 | 0.4671 | 0.4671 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase I | 0.0115 | 0.4671 | 0.4671 |
Schistosoma mansoni | hypothetical protein | 0.0125 | 0.5586 | 0.5586 |
Leishmania major | carbonic anhydrase-like protein | 0.0173 | 1 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0173 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0172 | 0.9886 | 0.9886 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 2 uM | Inhibition of HIV1 recombinant wild type integrase strand transfer activity by gel-based assay | ChEMBL. | 25150089 |
IC50 (binding) | = 5 uM | Inhibition of HIV1 recombinant wild type integrase 3'-processing activity by gel-based assays | ChEMBL. | 25150089 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.