Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | O-glycosyl hydrolase family 30 protein | 0.0258 | 0.4478 | 1 |
Plasmodium falciparum | DNA-directed RNA polymerase II subunit RPB2, putative | 0.0028 | 0.0181 | 0.062 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0178 | 0.2987 | 0.6531 |
Loa Loa (eye worm) | RNA polymerase III 128kD subunit-PA | 0.0028 | 0.0181 | 0.0217 |
Toxoplasma gondii | inositol(myo)-1(or 4)-monophosphatase 2, putative | 0.0037 | 0.0338 | 0.4088 |
Schistosoma mansoni | DNA-directed RNA polymerase III subunit | 0.0028 | 0.0181 | 0.2002 |
Toxoplasma gondii | DNA-directed RNA polymerase III RPC2 | 0.0028 | 0.0181 | 0.2002 |
Toxoplasma gondii | DNA-directed RNA polymerase II RPB2 | 0.0028 | 0.0181 | 0.2002 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.0338 | 0.4088 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0169 | 0.2817 | 0.6134 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0258 | 0.4478 | 1 |
Echinococcus granulosus | inositol monophosphatase 1 | 0.0037 | 0.0338 | 0.2609 |
Plasmodium falciparum | DNA-directed RNA polymerase subunit beta, putative | 0.015 | 0.2461 | 1 |
Mycobacterium leprae | DNA-DIRECTED RNA POLYMERASE (BETA CHAIN) RPOB (TRANSCRIPTASE BETA CHAIN) (RNA POLYMERASE BETA SUBUNIT) | 0.0552 | 1 | 1 |
Loa Loa (eye worm) | inositol-1 | 0.0037 | 0.0338 | 0.0574 |
Giardia lamblia | DNA-directed RNA polymerase RPB2 | 0.0028 | 0.0181 | 1 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0338 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0169 | 0.2817 | 0.6134 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0169 | 0.2817 | 0.6134 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.0783 | 0.046 |
Trypanosoma cruzi | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0338 | 1 |
Trypanosoma cruzi | RNA polymerase I second largest subunit, putative | 0.002 | 0.003 | 0.0901 |
Leishmania major | DNA-directed RNA polymerase polypeptide, putative | 0.0028 | 0.0181 | 0.2002 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.0783 | 1 |
Leishmania major | myo-inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0338 | 0.4088 |
Giardia lamblia | DNA-directed RNA polymerase subunit B | 0.0028 | 0.0181 | 1 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0061 | 0.0783 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0178 | 0.2987 | 0.6531 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0061 | 0.0783 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0258 | 0.4478 | 1 |
Schistosoma mansoni | DNA-directed RNA polymerase III subunit | 0.0028 | 0.0181 | 0.2002 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0061 | 0.0783 | 0.2704 |
Treponema pallidum | DNA-directed RNA polymerase subunit beta | 0.0552 | 1 | 0.5 |
Plasmodium vivax | DNA-directed RNA polymerase III subunit, putative | 0.0028 | 0.0181 | 1 |
Trypanosoma brucei | DNA-directed RNA polymerase II subunit 2, putative | 0.0028 | 0.0181 | 0.4897 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0258 | 0.4478 | 1 |
Mycobacterium ulcerans | DNA-directed RNA polymerase subunit beta | 0.0552 | 1 | 1 |
Trypanosoma brucei | DNA-directed RNA polymerase III, putative | 0.0028 | 0.0181 | 0.4897 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0169 | 0.2817 | 0.6134 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0258 | 0.4478 | 1 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.0783 | 0.046 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0169 | 0.2817 | 0.6134 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0258 | 0.4478 | 1 |
Schistosoma mansoni | inositol monophosphatase | 0.0037 | 0.0338 | 0.4088 |
Echinococcus multilocularis | inositol monophosphatase 1 | 0.0037 | 0.0338 | 0.2609 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.0338 | 0.0365 |
Plasmodium vivax | DNA-directed RNA polymerase II subunit RPB2, putative | 0.0028 | 0.0181 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0061 | 0.0783 | 1 |
Schistosoma mansoni | DNA-directed rna polymerase II subunit | 0.0028 | 0.0181 | 0.2002 |
Trypanosoma brucei | inositol-1(or 4)-monophosphatase 1, putative | 0.0037 | 0.0338 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA-directed RNA polymerase subunit beta/beta' | 0.0552 | 1 | 1 |
Mycobacterium tuberculosis | DNA-directed RNA polymerase (beta chain) RpoB (transcriptase beta chain) (RNA polymerase beta subunit) | 0.0135 | 0.2179 | 1 |
Trichomonas vaginalis | inositol monophosphatase, putative | 0.0037 | 0.0338 | 0.0365 |
Brugia malayi | Inositol-1 | 0.0037 | 0.0338 | 0.0365 |
Onchocerca volvulus | Glucosylceramidase homolog | 0.0169 | 0.2817 | 0.5 |
Entamoeba histolytica | myo-inositol monophosphatase, putative | 0.0037 | 0.0338 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0258 | 0.4478 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0061 | 0.0783 | 1 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0169 | 0.2817 | 0.6134 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.0061 | 0.0783 | 1 |
Brugia malayi | O-Glycosyl hydrolase family 30 protein | 0.0258 | 0.4478 | 1 |
Plasmodium falciparum | DNA-directed RNA polymerase III subunit RPC2, putative | 0.0028 | 0.0181 | 0.062 |
Trichomonas vaginalis | glucosylceramidase, putative | 0.0169 | 0.2817 | 0.6134 |
Loa Loa (eye worm) | DNA-directed RNA polymerase II second largest subunit | 0.0028 | 0.0181 | 0.0217 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0061 | 0.0783 | 0.046 |
Trypanosoma cruzi | DNA-directed RNA polymerase III, putative | 0.0028 | 0.0181 | 0.5356 |
Trichomonas vaginalis | myo inositol monophosphatase, putative | 0.0037 | 0.0338 | 0.0365 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 20 uM | Inhibition of human recombinant AChE using acetylthiocholine iodide substrate incubated for 15 mins by spectrophotometry based Ellman's method | ChEMBL. | 25189690 |
IC50 (binding) | > 40 uM | Inhibition of human recombinant BuChE using butyrylthiocholine iodide substrate incubated for 15 mins by spectrophotometry based Ellman's method | ChEMBL. | 25189690 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.