Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | adenosine A1 receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A2a receptor | Starlite/ChEMBL | References |
Homo sapiens | adenosine A3 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | adenosine A2a receptor | 412 aa | 336 aa | 22.3 % |
Brugia malayi | hypothetical protein | adenosine A1 receptor | 326 aa | 305 aa | 21.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | tubulin beta-1 chain | 0.0078 | 1 | 1 |
Leishmania major | beta tubulin | 0.0078 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0078 | 1 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0078 | 1 | 1 |
Echinococcus multilocularis | beta tubulin | 0.0078 | 1 | 1 |
Leishmania major | beta tubulin | 0.0078 | 1 | 1 |
Toxoplasma gondii | beta tubulin | 0.0078 | 1 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0078 | 1 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0078 | 1 | 1 |
Leishmania major | beta tubulin | 0.0078 | 1 | 1 |
Leishmania major | beta tubulin | 0.0078 | 1 | 1 |
Trichomonas vaginalis | tubulin beta chain, putative | 0.0078 | 1 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0078 | 1 | 1 |
Entamoeba histolytica | tubulin family protein | 0.0078 | 1 | 1 |
Trichomonas vaginalis | tubulin, putative | 0.0078 | 1 | 1 |
Leishmania major | beta tubulin | 0.0078 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.0078 | 1 | 1 |
Echinococcus multilocularis | tubulin subunit beta | 0.0078 | 1 | 1 |
Loa Loa (eye worm) | tubulin beta-4 chain | 0.0078 | 1 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0078 | 1 | 1 |
Toxoplasma gondii | beta-1 tubulin, putative | 0.0078 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0078 | 1 | 1 |
Echinococcus granulosus | tubulin subunit beta | 0.0078 | 1 | 1 |
Trichomonas vaginalis | tubulin epsilon chain, putative | 0.0078 | 1 | 1 |
Leishmania major | beta tubulin | 0.0078 | 1 | 1 |
Loa Loa (eye worm) | tubulin beta chain | 0.0078 | 1 | 1 |
Leishmania major | beta tubulin | 0.0078 | 1 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0078 | 1 | 1 |
Giardia lamblia | Beta tubulin | 0.0078 | 1 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0078 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0078 | 1 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0078 | 1 | 1 |
Leishmania major | beta tubulin | 0.0078 | 1 | 1 |
Echinococcus granulosus | tubulin beta 4A class IVa | 0.0078 | 1 | 1 |
Loa Loa (eye worm) | tubulin beta-2A chain | 0.0078 | 1 | 1 |
Toxoplasma gondii | beta-tubulin, putative | 0.0078 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.0078 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0078 | 1 | 1 |
Leishmania major | beta tubulin | 0.0078 | 1 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0078 | 1 | 1 |
Plasmodium falciparum | tubulin beta chain | 0.0078 | 1 | 1 |
Echinococcus granulosus | Tubulin beta 2C chain | 0.0078 | 1 | 1 |
Trichomonas vaginalis | tubulin alpha chain, putative | 0.0078 | 1 | 1 |
Brugia malayi | beta-tubulin, identical | 0.0078 | 1 | 1 |
Leishmania major | beta tubulin | 0.0078 | 1 | 1 |
Leishmania major | beta tubulin | 0.0078 | 1 | 1 |
Leishmania major | beta tubulin | 0.0078 | 1 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0078 | 1 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0078 | 1 | 1 |
Leishmania major | beta tubulin | 0.0078 | 1 | 1 |
Leishmania major | beta tubulin | 0.0078 | 1 | 1 |
Echinococcus granulosus | beta tubulin | 0.0078 | 1 | 1 |
Echinococcus granulosus | beta tubulin | 0.0078 | 1 | 1 |
Echinococcus multilocularis | Tubulin beta 2C chain | 0.0078 | 1 | 1 |
Trichomonas vaginalis | tubulin gamma chain, putative | 0.0078 | 1 | 1 |
Leishmania major | beta tubulin | 0.0078 | 1 | 1 |
Leishmania major | beta tubulin | 0.0078 | 1 | 1 |
Giardia lamblia | Beta tubulin | 0.0078 | 1 | 1 |
Leishmania major | beta tubulin | 0.0078 | 1 | 1 |
Loa Loa (eye worm) | beta-tubulin | 0.0078 | 1 | 1 |
Echinococcus multilocularis | tubulin, beta 4A class IVa | 0.0078 | 1 | 1 |
Echinococcus multilocularis | beta tubulin | 0.0078 | 1 | 1 |
Giardia lamblia | Beta tubulin | 0.0078 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.0078 | 1 | 1 |
Loa Loa (eye worm) | BEN-1 protein | 0.0078 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0078 | 1 | 1 |
Echinococcus multilocularis | tubulin beta 1 chain | 0.0078 | 1 | 1 |
Echinococcus granulosus | tubulin beta 1 chain | 0.0078 | 1 | 1 |
Trypanosoma brucei | beta tubulin | 0.0078 | 1 | 1 |
Leishmania major | beta tubulin | 0.0078 | 1 | 1 |
Plasmodium vivax | tubulin beta chain, putative | 0.0078 | 1 | 1 |
Schistosoma mansoni | tubulin subunit beta | 0.0078 | 1 | 1 |
Trypanosoma cruzi | beta tubulin, putative | 0.0078 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.037 uM | Inhibition of [125I]- AB-MECA binding to human adenosine A3 receptor expressed in CHO cells | ChEMBL. | 16033270 |
Ki (binding) | = 2.22 uM | Percent inhibition of [3H]-DPCPX binding to human adenosine A1 receptor expressed in CHO cells at 10 uM | ChEMBL. | 16033270 |
Ki (binding) | = 7.73 uM | Percent inhibition of [3H]ZM241,385 binding to human adenosine A2a receptor expressed in CHO cells at 10 uM | ChEMBL. | 16033270 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.