Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glutamyl tRNAGln amidotransferase subunit A | 0.009 | 0.0177 | 0.0744 |
Plasmodium vivax | PST-A protein | 0.058 | 0.1823 | 1 |
Mycobacterium ulcerans | peptide amidase, GatA | 0.009 | 0.0177 | 0.0177 |
Mycobacterium leprae | POSSIBLE LYSOPHOSPHOLIPASE | 0.0617 | 0.1948 | 1 |
Leishmania major | hypothetical protein, conserved | 0.009 | 0.0177 | 0.0969 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.058 | 0.1823 | 0.5 |
Echinococcus multilocularis | glutamyl tRNA(Gln) amidotransferase subunit A | 0.009 | 0.0177 | 0.0744 |
Mycobacterium ulcerans | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD | 0.3015 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.0214 | 0.0903 |
Brugia malayi | Amidase family protein | 0.009 | 0.0177 | 0.0744 |
Giardia lamblia | Hypothetical protein | 0.0037 | 0 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.058 | 0.1823 | 1 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.058 | 0.1823 | 0.5 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.058 | 0.1823 | 1 |
Mycobacterium ulcerans | amidase | 0.009 | 0.0177 | 0.0177 |
Trypanosoma cruzi | amidase, putative | 0.009 | 0.0177 | 0.0969 |
Mycobacterium ulcerans | amidase | 0.009 | 0.0177 | 0.0177 |
Schistosoma mansoni | neuropathy target esterase/swiss cheese-related protein | 0.0093 | 0.0189 | 0.0795 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0744 | 0.2373 | 1 |
Toxoplasma gondii | hydrolase, alpha/beta fold family protein | 0.0037 | 0 | 0.5 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.009 | 0.0177 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.058 | 0.1823 | 1 |
Mycobacterium ulcerans | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.009 | 0.0177 | 0.0177 |
Brugia malayi | putative amidase | 0.009 | 0.0177 | 0.0744 |
Trypanosoma cruzi | amidase, putative | 0.009 | 0.0177 | 0.0969 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.009 | 0.0177 | 0.0744 |
Giardia lamblia | Hypothetical protein | 0.0037 | 0 | 0.5 |
Trypanosoma brucei | fatty-acid amide hydrolase, putative | 0.009 | 0.0177 | 0.0969 |
Plasmodium falciparum | lysophospholipase, putative | 0.058 | 0.1823 | 1 |
Leishmania major | monoglyceride lipase, putative | 0.058 | 0.1823 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.058 | 0.1823 | 1 |
Mycobacterium ulcerans | lysophospholipase | 0.058 | 0.1823 | 0.1823 |
Toxoplasma gondii | hypothetical protein | 0.0037 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.009 | 0.0177 | 0.5 |
Brugia malayi | Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative | 0.0101 | 0.0214 | 0.0903 |
Toxoplasma gondii | hypothetical protein | 0.0037 | 0 | 0.5 |
Plasmodium falciparum | esterase, putative | 0.058 | 0.1823 | 1 |
Toxoplasma gondii | chain a, pp2a-specific methylesterase apo form (pme), putative | 0.0037 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable amidase AmiB2 (aminohydrolase) | 0.009 | 0.0177 | 0.0177 |
Mycobacterium leprae | PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) | 0.009 | 0.0177 | 0.0907 |
Giardia lamblia | Hypothetical protein | 0.0037 | 0 | 0.5 |
Mycobacterium ulcerans | amidase | 0.009 | 0.0177 | 0.0177 |
Schistosoma mansoni | amidase | 0.0744 | 0.2373 | 1 |
Echinococcus granulosus | patatin phospholipase domain containing protein | 0.0101 | 0.0214 | 0.0903 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.009 | 0.0177 | 0.0744 |
Echinococcus multilocularis | patatin phospholipase domain containing protein | 0.0101 | 0.0214 | 0.0903 |
Plasmodium falciparum | lysophospholipase, putative | 0.058 | 0.1823 | 1 |
Mycobacterium tuberculosis | Possible amidase (aminohydrolase) | 0.009 | 0.0177 | 0.0177 |
Brugia malayi | Amidase family protein | 0.009 | 0.0177 | 0.0744 |
Loa Loa (eye worm) | amidase | 0.009 | 0.0177 | 0.0744 |
Giardia lamblia | Protein phosphatase methylesterase-1 | 0.0037 | 0 | 0.5 |
Onchocerca volvulus | 0.0101 | 0.0214 | 1 | |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.058 | 0.1823 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0744 | 0.2373 | 1 |
Schistosoma mansoni | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.009 | 0.0177 | 0.0744 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0744 | 0.2373 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0744 | 0.2373 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0744 | 0.2373 | 1 |
Mycobacterium tuberculosis | Probable amidase AmiC (aminohydrolase) | 0.009 | 0.0177 | 0.0177 |
Mycobacterium leprae | PROBABLE AMIDASE AMIC (AMINOHYDROLASE) | 0.009 | 0.0177 | 0.0907 |
Trichomonas vaginalis | conserved hypothetical protein | 0.058 | 0.1823 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0744 | 0.2373 | 1 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.009 | 0.0177 | 0.5 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.058 | 0.1823 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.058 | 0.1823 | 1 |
Brugia malayi | amidase | 0.0744 | 0.2373 | 1 |
Plasmodium falciparum | lysophospholipase, putative | 0.058 | 0.1823 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.058 | 0.1823 | 0.1823 |
Loa Loa (eye worm) | amidase | 0.009 | 0.0177 | 0.0744 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.009 | 0.0177 | 0.0744 |
Toxoplasma gondii | hydrolase, alpha/beta fold family protein | 0.0037 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0101 | 0.0214 | 0.0214 |
Mycobacterium tuberculosis | Probable amidase AmiA2 (aminohydrolase) | 0.009 | 0.0177 | 0.0177 |
Mycobacterium ulcerans | amidase | 0.009 | 0.0177 | 0.0177 |
Mycobacterium tuberculosis | Probable amidase AmiD (acylamidase) (acylase) | 0.009 | 0.0177 | 0.0177 |
Schistosoma mansoni | neuropathy target esterase/swiss cheese-related protein | 0.0093 | 0.0189 | 0.0795 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.058 | 0.1823 | 1 |
Treponema pallidum | hypothetical protein | 0.0087 | 0.0168 | 0.9528 |
Giardia lamblia | ENC6 protein | 0.0037 | 0 | 0.5 |
Mycobacterium ulcerans | amidase | 0.009 | 0.0177 | 0.0177 |
Mycobacterium tuberculosis | Possible lysophospholipase | 0.0617 | 0.1948 | 0.1948 |
Trypanosoma cruzi | monoglyceride lipase, putative | 0.058 | 0.1823 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0037 | 0 | 0.5 |
Trichomonas vaginalis | valacyclovir hydrolase, putative | 0.058 | 0.1823 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 100 uM | Antimalarial activity against Plasmodium falciparum FCR3 after 48 hrs by parasite lactate dehydrogenase assay | ChEMBL. | 25255435 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.