Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tyrosinase precursor | 0.0181 | 0.1064 | 0.1064 |
Echinococcus granulosus | cathepsin b | 0.0882 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0882 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0165 | 0.086 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0165 | 0.086 | 0.086 |
Brugia malayi | Cathepsin L-like precursor | 0.0119 | 0.0274 | 0.0274 |
Giardia lamblia | Cathepsin B precursor | 0.0308 | 0.2688 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Loa Loa (eye worm) | cathepsin B | 0.0308 | 0.2688 | 0.2482 |
Loa Loa (eye worm) | cysteine protease | 0.0165 | 0.086 | 0.0603 |
Brugia malayi | Cathepsin L-like precursor | 0.0119 | 0.0274 | 0.0274 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0165 | 0.086 | 0.3201 |
Brugia malayi | Cathepsin L-like precursor | 0.0165 | 0.086 | 0.086 |
Schistosoma mansoni | tyrosinase precursor | 0.0181 | 0.1064 | 0.1064 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0882 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0882 | 1 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0119 | 0.0274 | 0.0274 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0308 | 0.2688 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0165 | 0.086 | 0.086 |
Loa Loa (eye worm) | ctsf protein | 0.0165 | 0.086 | 0.0603 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0119 | 0.0274 | 0.0274 |
Entamoeba histolytica | cysteine protease, putative | 0.0165 | 0.086 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0165 | 0.086 | 0.0603 |
Brugia malayi | ShTK domain containing protein | 0.0181 | 0.1064 | 0.1064 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0181 | 0.1064 | 0.0812 |
Brugia malayi | Cathepsin L-like precursor | 0.0165 | 0.086 | 0.086 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0165 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Brugia malayi | cathepsin L-like precursor | 0.0119 | 0.0274 | 0.0274 |
Brugia malayi | Cathepsin L-like precursor | 0.0165 | 0.086 | 0.086 |
Loa Loa (eye worm) | ShTK domain-containing protein | 0.0181 | 0.1064 | 0.0812 |
Echinococcus multilocularis | cysteine protease | 0.0165 | 0.086 | 0.086 |
Onchocerca volvulus | 0.0181 | 0.1064 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0119 | 0.0274 | 0.1018 |
Onchocerca volvulus | 0.0165 | 0.086 | 0.7426 | |
Loa Loa (eye worm) | tyrosinase 1 | 0.0181 | 0.1064 | 0.0812 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0165 | 0.086 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0165 | 0.086 | 0.0603 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0165 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Brugia malayi | Cathepsin L-like precursor | 0.0165 | 0.086 | 0.086 |
Plasmodium vivax | vivapain-2 | 0.0165 | 0.086 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0165 | 0.086 | 0.0603 |
Onchocerca volvulus | 0.0165 | 0.086 | 0.7426 | |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0165 | 0.086 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0165 | 0.086 | 0.086 |
Brugia malayi | Cathepsin L-like precursor | 0.0165 | 0.086 | 0.086 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0119 | 0.0274 | 0.3182 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0165 | 0.086 | 0.086 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0165 | 0.086 | 0.086 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0308 | 0.2688 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0119 | 0.0274 | 0.1018 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0165 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.1064 | 0.0812 |
Onchocerca volvulus | Cathepsin L homolog | 0.0165 | 0.086 | 0.7426 |
Onchocerca volvulus | 0.0165 | 0.086 | 0.7426 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Giardia lamblia | Cathepsin B precursor | 0.0308 | 0.2688 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0165 | 0.086 | 0.086 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0181 | 0.1064 | 0.1064 |
Echinococcus multilocularis | cathepsin b | 0.0882 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Onchocerca volvulus | 0.0165 | 0.086 | 0.7426 | |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0181 | 0.1064 | 0.1064 |
Onchocerca volvulus | 0.0181 | 0.1064 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0882 | 1 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0165 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Loa Loa (eye worm) | hypothetical protein | 0.0882 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0882 | 1 | 1 |
Plasmodium vivax | vivapain-2 | 0.0165 | 0.086 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0165 | 0.086 | 0.086 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0165 | 0.086 | 0.3201 |
Onchocerca volvulus | 0.0165 | 0.086 | 0.7426 | |
Giardia lamblia | Cathepsin B precursor | 0.0308 | 0.2688 | 0.5 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0165 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0165 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Onchocerca volvulus | Cathepsin L homolog | 0.0165 | 0.086 | 0.7426 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0882 | 1 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0165 | 0.086 | 0.086 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0165 | 0.086 | 0.086 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0165 | 0.086 | 0.086 |
Loa Loa (eye worm) | hypothetical protein | 0.0181 | 0.1064 | 0.0812 |
Brugia malayi | Common central domain of tyrosinase family protein | 0.0181 | 0.1064 | 0.1064 |
Onchocerca volvulus | 0.0165 | 0.086 | 0.7426 | |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0165 | 0.086 | 0.086 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0308 | 0.2688 | 0.2688 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0165 | 0.086 | 0.086 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0165 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0165 | 0.086 | 0.3201 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0165 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Toxoplasma gondii | cathepsin B | 0.0308 | 0.2688 | 1 |
Onchocerca volvulus | Cathepsin F homolog | 0.0165 | 0.086 | 0.7426 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0308 | 0.2688 | 1 |
Onchocerca volvulus | 0.0181 | 0.1064 | 1 | |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0119 | 0.0274 | 0.0274 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0165 | 0.086 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0165 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Echinococcus granulosus | cathepsin l1 | 0.0165 | 0.086 | 0.086 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0308 | 0.2688 | 0.2688 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Onchocerca volvulus | 0.0181 | 0.1064 | 1 | |
Echinococcus granulosus | cathepsin l1 | 0.0119 | 0.0274 | 0.0274 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0165 | 0.086 | 1 |
Onchocerca volvulus | 0.0165 | 0.086 | 0.7426 | |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0165 | 0.086 | 0.086 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0165 | 0.086 | 0.086 |
Brugia malayi | Cathepsin L-like precursor | 0.0165 | 0.086 | 0.086 |
Loa Loa (eye worm) | fibroinase | 0.0165 | 0.086 | 0.0603 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0165 | 0.086 | 0.3201 |
Echinococcus multilocularis | cathepsin b | 0.0882 | 1 | 1 |
Brugia malayi | Hypothetical tyrosinase-like protein F21C3.2 in chromosome I | 0.0181 | 0.1064 | 0.1064 |
Brugia malayi | Hypothetical tyrosinase-like protein C02C2.1 in chromosome III | 0.0181 | 0.1064 | 0.1064 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 58 % | Antiinflammatory activity in mouse assessed as reduction in PMA-induced ear edema at 0.1 mg/ear administered topically measured after 24 hrs relative to control | ChEMBL. | 25240256 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.