Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.2658 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.2658 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.2658 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.2658 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0933 | 0.2822 | 1 |
Echinococcus multilocularis | cathepsin b | 0.2658 | 1 | 1 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0529 | 0.1142 | 0.0934 |
Entamoeba histolytica | cysteine protease, putative | 0.0529 | 0.1142 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0623 | 0.1534 | 0.503 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0623 | 0.1534 | 0.503 |
Onchocerca volvulus | 0.0529 | 0.1142 | 1 | |
Brugia malayi | cathepsin L-like precursor | 0.038 | 0.052 | 0.0297 |
Onchocerca volvulus | Cathepsin L homolog | 0.0529 | 0.1142 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0623 | 0.1534 | 0.1534 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0623 | 0.1534 | 0.503 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0933 | 0.2822 | 1 |
Trypanosoma cruzi | cysteine protease, putative | 0.031 | 0.023 | 0.023 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0623 | 0.1534 | 0.1534 |
Loa Loa (eye worm) | hypothetical protein | 0.2658 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.2658 | 1 | 1 |
Onchocerca volvulus | 0.0529 | 0.1142 | 1 | |
Echinococcus multilocularis | cysteine protease | 0.0529 | 0.1142 | 0.0934 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0529 | 0.1142 | 0.0934 |
Echinococcus granulosus | cathepsin b | 0.2658 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0529 | 0.1142 | 0.0934 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Leishmania major | cathepsin L-like protease | 0.0623 | 0.1534 | 0.2332 |
Plasmodium vivax | vivapain-2 | 0.0529 | 0.1142 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.038 | 0.052 | 0.0297 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0529 | 0.1142 | 0.0656 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0623 | 0.1534 | 0.503 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.2658 | 1 | 1 |
Onchocerca volvulus | 0.0529 | 0.1142 | 1 | |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0529 | 0.1142 | 0.0934 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0623 | 0.1534 | 0.503 |
Onchocerca volvulus | Cathepsin L homolog | 0.0529 | 0.1142 | 1 |
Toxoplasma gondii | cathepsin B | 0.0933 | 0.2822 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0529 | 0.1142 | 1 |
Loa Loa (eye worm) | fibroinase | 0.0529 | 0.1142 | 0.0656 |
Entamoeba histolytica | cysteine proteinase, putative | 0.038 | 0.052 | 0.3182 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0474 | 0.0912 | 0.0912 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Onchocerca volvulus | Cathepsin F homolog | 0.0529 | 0.1142 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0933 | 0.2822 | 0.2428 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.031 | 0.023 | 0.023 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0529 | 0.1142 | 0.0934 |
Brugia malayi | Cathepsin L-like precursor | 0.0529 | 0.1142 | 0.0934 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0529 | 0.1142 | 0.0934 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Loa Loa (eye worm) | ctsf protein | 0.0529 | 0.1142 | 0.0656 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0529 | 0.1142 | 1 |
Onchocerca volvulus | 0.0529 | 0.1142 | 1 | |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0529 | 0.1142 | 0.0656 |
Brugia malayi | Cathepsin L-like precursor | 0.038 | 0.052 | 0.0297 |
Echinococcus multilocularis | cysteine protease | 0.0529 | 0.1142 | 0.0934 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0529 | 0.1142 | 0.0934 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0529 | 0.1142 | 0.1142 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.038 | 0.052 | 0.0297 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0529 | 0.1142 | 0.0934 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.038 | 0.052 | 0.112 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Giardia lamblia | Cathepsin B precursor | 0.0933 | 0.2822 | 0.5 |
Trypanosoma cruzi | cysteine peptidase (N-terminal), putative | 0.031 | 0.023 | 0.023 |
Loa Loa (eye worm) | cysteine protease | 0.0529 | 0.1142 | 0.0656 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0623 | 0.1534 | 0.503 |
Leishmania major | cathepsin L-like protease | 0.0623 | 0.1534 | 0.2332 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Plasmodium vivax | vivapain-2 | 0.0529 | 0.1142 | 1 |
Trypanosoma cruzi | cysteine proteinase, putative | 0.031 | 0.023 | 0.023 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0623 | 0.1534 | 0.503 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0623 | 0.1534 | 0.1534 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0529 | 0.1142 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0529 | 0.1142 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0933 | 0.2822 | 0.5 |
Leishmania major | cathepsin L-like protease | 0.0623 | 0.1534 | 0.2332 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0529 | 0.1142 | 0.0934 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.2658 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Loa Loa (eye worm) | hypothetical protein | 0.0529 | 0.1142 | 0.0656 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0623 | 0.1534 | 0.503 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0623 | 0.1534 | 0.503 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0623 | 0.1534 | 0.503 |
Brugia malayi | Cathepsin L-like precursor | 0.0529 | 0.1142 | 0.0934 |
Giardia lamblia | Cathepsin B precursor | 0.0933 | 0.2822 | 0.5 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0529 | 0.1142 | 0.0934 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0529 | 0.1142 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0529 | 0.1142 | 0.0934 |
Brugia malayi | Cathepsin L-like precursor | 0.0529 | 0.1142 | 0.0934 |
Onchocerca volvulus | 0.0529 | 0.1142 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Brugia malayi | Cathepsin L-like precursor | 0.038 | 0.052 | 0.0297 |
Onchocerca volvulus | 0.0529 | 0.1142 | 1 | |
Trypanosoma cruzi | cysteine proteinase, putative | 0.031 | 0.023 | 0.023 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0933 | 0.2822 | 0.2653 |
Echinococcus granulosus | cathepsin l1 | 0.038 | 0.052 | 0.0297 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0529 | 0.1142 | 0.3519 |
Brugia malayi | Cathepsin L-like precursor | 0.0529 | 0.1142 | 0.0934 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0933 | 0.2822 | 0.2822 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0623 | 0.1534 | 0.503 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.038 | 0.052 | 0.112 |
Echinococcus granulosus | cathepsin l1 | 0.0529 | 0.1142 | 0.0934 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0623 | 0.1534 | 0.1534 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0933 | 0.2822 | 1 |
Onchocerca volvulus | 0.0529 | 0.1142 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 21.8 % | Antidepressant activity in C57BL/6 mouse assessed as decrease in immobility duration at 10 mg/kg, ig by tail suspension test | ChEMBL. | 25442321 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.