Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Amidase family protein | 0.0118 | 0.0177 | 0.0744 |
Trypanosoma brucei | fatty-acid amide hydrolase, putative | 0.0118 | 0.0177 | 0.0901 |
Plasmodium falciparum | lysophospholipase, putative | 0.0819 | 0.1961 | 1 |
Onchocerca volvulus | 0.0156 | 0.0273 | 1 | |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0819 | 0.1961 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0981 | 0.2373 | 1 |
Giardia lamblia | Protein phosphatase methylesterase-1 | 0.0049 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable amidase AmiB2 (aminohydrolase) | 0.0118 | 0.0177 | 0.0177 |
Echinococcus granulosus | patatin phospholipase domain containing protein | 0.0156 | 0.0273 | 0.1151 |
Schistosoma mansoni | amidase | 0.0981 | 0.2373 | 1 |
Loa Loa (eye worm) | amidase | 0.0118 | 0.0177 | 0.0744 |
Echinococcus multilocularis | patatin phospholipase domain containing protein | 0.0156 | 0.0273 | 0.1151 |
Schistosoma mansoni | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0118 | 0.0177 | 0.0744 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0981 | 0.2373 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0819 | 0.1961 | 1 |
Mycobacterium ulcerans | amidase | 0.0118 | 0.0177 | 0.0177 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0819 | 0.1961 | 1 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0819 | 0.1961 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0981 | 0.2373 | 1 |
Mycobacterium ulcerans | amidase | 0.0118 | 0.0177 | 0.0177 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0981 | 0.2373 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0981 | 0.2373 | 1 |
Trypanosoma cruzi | amidase, putative | 0.0118 | 0.0177 | 0.0901 |
Mycobacterium tuberculosis | Probable amidase AmiD (acylamidase) (acylase) | 0.0118 | 0.0177 | 0.0177 |
Toxoplasma gondii | hydrolase, alpha/beta fold family protein | 0.0049 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0156 | 0.0273 | 0.0273 |
Echinococcus multilocularis | glutamyl tRNA(Gln) amidotransferase subunit A | 0.0118 | 0.0177 | 0.0744 |
Mycobacterium tuberculosis | Possible amidase (aminohydrolase) | 0.0118 | 0.0177 | 0.0177 |
Mycobacterium ulcerans | amidase | 0.0118 | 0.0177 | 0.0177 |
Mycobacterium ulcerans | hypothetical protein | 0.0819 | 0.1961 | 0.1961 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0118 | 0.0177 | 0.5 |
Brugia malayi | amidase | 0.0981 | 0.2373 | 1 |
Plasmodium falciparum | lysophospholipase, putative | 0.0819 | 0.1961 | 1 |
Loa Loa (eye worm) | amidase | 0.0118 | 0.0177 | 0.0744 |
Trypanosoma cruzi | monoglyceride lipase, putative | 0.0819 | 0.1961 | 1 |
Mycobacterium tuberculosis | Possible lysophospholipase | 0.0868 | 0.2085 | 0.2085 |
Trichomonas vaginalis | valacyclovir hydrolase, putative | 0.0819 | 0.1961 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0049 | 0 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0819 | 0.1961 | 1 |
Mycobacterium leprae | PROBABLE AMIDASE AMIC (AMINOHYDROLASE) | 0.0118 | 0.0177 | 0.0847 |
Schistosoma mansoni | neuropathy target esterase/swiss cheese-related protein | 0.0144 | 0.0243 | 0.1023 |
Mycobacterium tuberculosis | Probable amidase AmiA2 (aminohydrolase) | 0.0118 | 0.0177 | 0.0177 |
Giardia lamblia | ENC6 protein | 0.0049 | 0 | 0.5 |
Brugia malayi | putative amidase | 0.0118 | 0.0177 | 0.0744 |
Loa Loa (eye worm) | hypothetical protein | 0.0156 | 0.0273 | 0.1151 |
Mycobacterium ulcerans | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD | 0.3976 | 1 | 1 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0118 | 0.0177 | 0.8064 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0118 | 0.0177 | 0.0744 |
Schistosoma mansoni | neuropathy target esterase/swiss cheese-related protein | 0.0144 | 0.0243 | 0.1023 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0819 | 0.1961 | 1 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0819 | 0.1961 | 1 |
Mycobacterium ulcerans | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0118 | 0.0177 | 0.0177 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0819 | 0.1961 | 1 |
Giardia lamblia | Hypothetical protein | 0.0049 | 0 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0118 | 0.0177 | 0.0744 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0819 | 0.1961 | 0.5 |
Mycobacterium leprae | POSSIBLE LYSOPHOSPHOLIPASE | 0.0868 | 0.2085 | 1 |
Trypanosoma cruzi | amidase, putative | 0.0118 | 0.0177 | 0.0901 |
Mycobacterium ulcerans | peptide amidase, GatA | 0.0118 | 0.0177 | 0.0177 |
Plasmodium vivax | PST-A protein | 0.0819 | 0.1961 | 1 |
Mycobacterium ulcerans | amidase | 0.0118 | 0.0177 | 0.0177 |
Echinococcus granulosus | glutamyl tRNAGln amidotransferase subunit A | 0.0118 | 0.0177 | 0.0744 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0819 | 0.1961 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0118 | 0.0177 | 0.0744 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0118 | 0.0177 | 0.5 |
Treponema pallidum | hypothetical protein | 0.0135 | 0.0219 | 1 |
Mycobacterium leprae | PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) | 0.0118 | 0.0177 | 0.0847 |
Toxoplasma gondii | hydrolase, alpha/beta fold family protein | 0.0049 | 0 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0981 | 0.2373 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0049 | 0 | 0.5 |
Mycobacterium ulcerans | lysophospholipase | 0.0819 | 0.1961 | 0.1961 |
Brugia malayi | Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative | 0.0156 | 0.0273 | 0.1151 |
Brugia malayi | Amidase family protein | 0.0118 | 0.0177 | 0.0744 |
Plasmodium falciparum | lysophospholipase, putative | 0.0819 | 0.1961 | 1 |
Giardia lamblia | Hypothetical protein | 0.0049 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0118 | 0.0177 | 0.0901 |
Leishmania major | monoglyceride lipase, putative | 0.0819 | 0.1961 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0819 | 0.1961 | 1 |
Toxoplasma gondii | chain a, pp2a-specific methylesterase apo form (pme), putative | 0.0049 | 0 | 0.5 |
Mycobacterium ulcerans | amidase | 0.0118 | 0.0177 | 0.0177 |
Giardia lamblia | Hypothetical protein | 0.0049 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable amidase AmiC (aminohydrolase) | 0.0118 | 0.0177 | 0.0177 |
Plasmodium falciparum | esterase, putative | 0.0819 | 0.1961 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0049 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 24.65 uM | Antiproliferative activity against human A549 cells after 3 days by SRB assay | ChEMBL. | 25241925 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.