TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 538.696 | Formula: C34H34O4S
H donors: 0 H acceptors: 0 LogP: 6.16 Rotable bonds: 10
Rule of 5 violations (Lipinski): 2
SMILES: c1ccc(cc1)CO[C@@H]1[C@@H](COCc2ccccc2)O[C@H]2[C@@H]([C@H]1OCc1ccccc1)CSc1c2cccc1
InChi: 1S/C34H34O4S/c1-4-12-25(13-5-1)20-35-23-30-34(37-22-27-16-8-3-9-17-27)33(36-21-26-14-6-2-7-15-26)29-24-39-31-19-11-10-18-28(31)32(29)38-30/h1-19,29-30,32-34H,20-24H2/t29-,30+,32+,33+,34+/m0/s1
InChiKey: RZCOWKNOSZAICT-VZDZRGPCSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.000972019	0.0126925	0.0578176
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.000972019	0.0126925	0.5
Echinococcus granulosus	neuroglian	0.000824644	0.00675668	0.0307785
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.00610732	0.219526	1
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.000972019	0.0126925	0.5
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.000972019	0.0126925	0.5
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.00610732	0.219526	1
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Schistosoma mansoni	hypothetical protein	0.00610732	0.219526	1
Echinococcus granulosus	G protein coupled receptor 139	0.00610732	0.219526	1
Brugia malayi	sulfakinin receptor protein	0.00610732	0.219526	0.544081
Schistosoma mansoni	opsin-like receptor	0.00610732	0.219526	1
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Brugia malayi	G protein-coupled receptor	0.00610732	0.219526	0.544081
Brugia malayi	ORL1-like opioid receptor	0.00610732	0.219526	0.544081
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.000972019	0.0126925	0.5
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.00610732	0.219526	1
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Echinococcus multilocularis	rhodopsin orphan GPCR	0.00610732	0.219526	1
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Brugia malayi	RE15519p	0.00610732	0.219526	0.544081
Echinococcus granulosus	7TM GPCR rhodopsin	0.00610732	0.219526	1
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.000972019	0.0126925	0.5
Schistosoma mansoni	neuropeptide receptor	0.00610732	0.219526	1
Echinococcus multilocularis	serotonin receptor	0.00610732	0.219526	1
Trichomonas vaginalis	cAMP-specific 3,5-cyclic phosphodiesterase, putative	0.000972019	0.0126925	0.5
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.000972019	0.0126925	0.5
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.000972019	0.0126925	0.0578176
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.000972019	0.0126925	0.5
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase R153.1, putative	0.000972019	0.0126925	0.0314575
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.00610732	0.219526	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.00610732	0.219526	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.00610732	0.219526	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.00610732	0.219526	1
Echinococcus multilocularis	somatostatin receptor	0.00610732	0.219526	1
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Echinococcus granulosus	high affinity cAMP specific 3'5' cyclic	0.000972019	0.0126925	0.0578176
Echinococcus multilocularis	rhodopsin orphan GPCR	0.00610732	0.219526	1
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.000972019	0.0126925	0.5
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Echinococcus multilocularis	neuropeptide receptor A26	0.00610732	0.219526	1
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.00610732	0.219526	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.00610732	0.219526	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.000972019	0.0126925	0.5
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.000972019	0.0126925	0.5
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.000972019	0.0126925	0.5
Echinococcus granulosus	biogenic amine 5HT receptor	0.00610732	0.219526	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.00610732	0.219526	1
Schistosoma mansoni	cgmp-dependent 35-cyclic phosphodiesterase	0.000972019	0.0126925	0.0578176
Echinococcus granulosus	neuropeptide FF receptor 2	0.00610732	0.219526	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.000972019	0.0126925	0.5
Brugia malayi	putative neuropeptide receptor NPR1	0.00610732	0.219526	0.544081
Loa Loa (eye worm)	G-protein coupled receptor	0.00610732	0.219526	0.544081
Echinococcus granulosus	tm gpcr rhodopsin	0.00610732	0.219526	1
Brugia malayi	G-protein coupled receptor	0.00610732	0.219526	0.544081
Loa Loa (eye worm)	G-protein coupled receptor	0.00610732	0.219526	0.544081
Brugia malayi	hypothetical protein	0.00610732	0.219526	0.544081
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.000972019	0.0126925	0.5
Echinococcus multilocularis	neuropeptides capa receptor	0.00610732	0.219526	1
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.000972019	0.0126925	0.5
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.000972019	0.0126925	0.5
Loa Loa (eye worm)	PDE1B protein	0.000972019	0.0126925	0.0314575
Brugia malayi	Serotonin receptor	0.00610732	0.219526	0.544081
Brugia malayi	Dopamine receptor protein 2	0.00610732	0.219526	0.544081
Echinococcus multilocularis	allatostatin A receptor	0.00610732	0.219526	1
Echinococcus multilocularis	g-protein coupled receptor	0.00610732	0.219526	1
Echinococcus granulosus	neuropeptide receptor	0.00610732	0.219526	1
Loa Loa (eye worm)	hypothetical protein	0.000972019	0.0126925	0.0314575
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.00610732	0.219526	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.00610732	0.219526	1
Schistosoma mansoni	cell adhesion molecule	0.000871038	0.00862529	0.0392905
Echinococcus granulosus	somatostatin receptor	0.00610732	0.219526	1
Loa Loa (eye worm)	neuropeptide F receptor	0.00610732	0.219526	0.544081
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.000972019	0.0126925	0.5
Brugia malayi	putative neuropeptide receptor	0.00610732	0.219526	0.544081
Echinococcus multilocularis	high affinity cgmp specific 3' 5' cyclic	0.000972019	0.0126925	0.0578176
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.000972019	0.0126925	0.0578176
Echinococcus multilocularis	orexin receptor type 2	0.00610732	0.219526	1
Echinococcus multilocularis	neuropeptide Y receptor	0.00610732	0.219526	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.00610732	0.219526	0.544081
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.000972019	0.0126925	0.5
Echinococcus granulosus	7tm_1 domain containing protein	0.00610732	0.219526	1
Echinococcus granulosus	g protein coupled receptor	0.00610732	0.219526	1
Echinococcus multilocularis	G protein coupled receptor 139	0.00610732	0.219526	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.00610732	0.219526	0.544081
Schistosoma mansoni	adenoreceptor	0.00610732	0.219526	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.00610732	0.219526	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.00610732	0.219526	1
Loa Loa (eye worm)	neuropeptide F receptor	0.00610732	0.219526	0.544081
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.00610732	0.219526	1
Schistosoma mansoni	neuropeptide receptor	0.00610732	0.219526	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.000972019	0.0126925	0.5
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.000972019	0.0126925	0.5
Brugia malayi	hypothetical protein	0.00610732	0.219526	0.544081
Echinococcus granulosus	cAMP and cAMP inhibited cGMP 3'5' cyclic	0.000972019	0.0126925	0.0578176
Echinococcus granulosus	rhodopsin orphan GPCR	0.00610732	0.219526	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.00610732	0.219526	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.000972019	0.0126925	0.5
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.00610732	0.219526	1
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.00610732	0.219526	1
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.000972019	0.0126925	0.5
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.00610732	0.219526	1
Trypanosoma brucei	3', 5'-cyclic nucleotide phosphodiesterase, putative	0.0254851	1	1
Brugia malayi	AKH receptor	0.00610732	0.219526	0.544081
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.000972019	0.0126925	0.5
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.000972019	0.0126925	0.0578176
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.000972019	0.0126925	0.5
Echinococcus granulosus	neuropeptides capa receptor	0.00610732	0.219526	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.00610732	0.219526	0.544081
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Echinococcus multilocularis	rhodopsin orphan GPCR	0.00610732	0.219526	1
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Echinococcus granulosus	biogenic amine 5HT receptor	0.00610732	0.219526	1
Trichomonas vaginalis	conserved hypothetical protein	0.000972019	0.0126925	0.5
Echinococcus granulosus	high affinity cgmp specific 3' 5' cyclic	0.000972019	0.0126925	0.0578176
Schistosoma mansoni	neuropeptide F-like receptor	0.00610732	0.219526	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.000972019	0.0126925	0.5
Echinococcus granulosus	allatostatin A receptor	0.00610732	0.219526	1
Brugia malayi	Melatonin receptor type 1A	0.00610732	0.219526	0.544081
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Schistosoma mansoni	neuropeptide receptor	0.00610732	0.219526	1
Echinococcus granulosus	tm gpcr rhodopsin	0.00610732	0.219526	1
Brugia malayi	G-protein coupled receptor	0.00610732	0.219526	0.544081
Echinococcus multilocularis	neuropeptide receptor	0.00610732	0.219526	1
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.000972019	0.0126925	0.5
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Schistosoma mansoni	hypothetical protein	0.00610732	0.219526	1
Schistosoma mansoni	amine GPCR	0.00610732	0.219526	1
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.000972019	0.0126925	0.0578176
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.000972019	0.0126925	0.5
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.00610732	0.219526	0.544081
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.00610732	0.219526	1
Trichomonas vaginalis	conserved hypothetical protein	0.000972019	0.0126925	0.5
Trichomonas vaginalis	cone cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.000972019	0.0126925	0.5
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Brugia malayi	Dopamine receptor protein 1	0.00610732	0.219526	0.544081
Loa Loa (eye worm)	TYRA-2 protein	0.00610732	0.219526	0.544081
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.000972019	0.0126925	0.5
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.000972019	0.0126925	0.5
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.000972019	0.0126925	0.5
Schistosoma mansoni	nephrin	0.000824644	0.00675668	0.0307785
Echinococcus granulosus	g-protein coupled receptor	0.00610732	0.219526	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.000972019	0.0126925	0.5
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.000972019	0.0126925	0.5
Loa Loa (eye worm)	hypothetical protein	0.000871038	0.00862529	0.0213772
Echinococcus granulosus	neuropeptide receptor A26	0.00610732	0.219526	1
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.00610732	0.219526	1
Schistosoma mansoni	amine GPCR	0.00610732	0.219526	1
Echinococcus granulosus	neurotracting:lsamp:neurotrimin:obcam	0.000871038	0.00862529	0.0392905
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.00610732	0.219526	1
Brugia malayi	hypothetical protein	0.00610732	0.219526	0.544081
Echinococcus granulosus	neuropeptide Y receptor	0.00610732	0.219526	1
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.000972019	0.0126925	0.0578176
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.000972019	0.0126925	0.0578176
Echinococcus multilocularis	neuropeptides capa receptor	0.00610732	0.219526	1
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.000972019	0.0126925	0.0578176
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Echinococcus multilocularis	dual 3',5' cyclic AMP and GMP phosphodiesterase	0.000972019	0.0126925	0.0578176
Giardia lamblia	hypothetical protein	0.000972019	0.0126925	0.5
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.00610732	0.219526	1
Echinococcus granulosus	serotonin receptor	0.00610732	0.219526	1
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Schistosoma mansoni	biogenic amine receptor	0.00610732	0.219526	1
Echinococcus granulosus	neuropeptide s receptor	0.00610732	0.219526	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.00610732	0.219526	1
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.00610732	0.219526	1
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.000972019	0.0126925	0.5
Brugia malayi	neuropeptide F receptor	0.00610732	0.219526	0.544081
Brugia malayi	neuropeptide F receptor	0.00610732	0.219526	0.544081
Echinococcus granulosus	tachykinin peptides receptor 99D	0.00610732	0.219526	1
Schistosoma mansoni	amine GPCR	0.00610732	0.219526	1
Loa Loa (eye worm)	hypothetical protein	0.000972019	0.0126925	0.0314575
Echinococcus multilocularis	cAMP and cAMP inhibited cGMP 3',5' cyclic	0.000972019	0.0126925	0.0578176
Echinococcus multilocularis	g protein coupled receptor	0.00610732	0.219526	1
Schistosoma mansoni	myosin xvIII	0.00610732	0.219526	1
Brugia malayi	hypothetical protein	0.00610732	0.219526	0.544081
Schistosoma mansoni	neuropeptide F-like receptor	0.00610732	0.219526	1
Echinococcus multilocularis	g protein coupled receptor	0.00610732	0.219526	1
Brugia malayi	hypothetical protein	0.00610732	0.219526	0.544081
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.00610732	0.219526	1
Trichomonas vaginalis	cAMP and cAMP-inhibited cGMP 3,5-cyclic phosphodiesterase, putative	0.000972019	0.0126925	0.5
Schistosoma mansoni	biogenic amine receptor	0.00610732	0.219526	1
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.000972019	0.0126925	0.5
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.000972019	0.0126925	0.5
Plasmodium vivax	cyclic nucleotide phosphodiesterase, putative	0.000972019	0.0126925	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.00610732	0.219526	1
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.000972019	0.0126925	0.5
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.00610732	0.219526	0.544081
Brugia malayi	Dopamine receptor	0.00610732	0.219526	0.544081
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Echinococcus multilocularis	G-protein coupled receptor, putative	0.00610732	0.219526	1
Schistosoma mansoni	opsin-like receptor	0.00610732	0.219526	1
Echinococcus granulosus	fmrfamide receptor	0.00610732	0.219526	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.00610732	0.219526	1
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.000972019	0.0126925	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.00610732	0.219526	1
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Schistosoma mansoni	camp-specific cyclic nucleotide phosphodiesterase	0.000972019	0.0126925	0.0578176
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.00610732	0.219526	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.00610732	0.219526	0.544081
Plasmodium vivax	phosphodiesterase gamma, putative	0.000972019	0.0126925	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.00610732	0.219526	1
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.000972019	0.0126925	0.5
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.000972019	0.0126925	0.5
Brugia malayi	hypothetical protein	0.00610732	0.219526	0.544081
Loa Loa (eye worm)	hypothetical protein	0.000972019	0.0126925	0.0314575
Brugia malayi	follicle stimulating hormone receptor	0.00610732	0.219526	0.544081
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.00610732	0.219526	1
Loa Loa (eye worm)	hypothetical protein	0.00103879	0.015382	0.0381233
Echinococcus multilocularis	g protein coupled receptor	0.00610732	0.219526	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase, putative	0.000972019	0.0126925	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.00610732	0.219526	1
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.000972019	0.0126925	0.5
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Giardia lamblia	CAMP-specific 3,5-cyclic phosphodiesterase 4B	0.000972019	0.0126925	0.5
Echinococcus multilocularis	serotonin receptor	0.00610732	0.219526	1
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Trichomonas vaginalis	cAMP-specific phosphodiesterase, putative	0.000972019	0.0126925	0.5
Plasmodium falciparum	cGMP-specific phosphodiesterase	0.000972019	0.0126925	0.5
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.000972019	0.0126925	0.5
Schistosoma mansoni	hypothetical protein	0.00610732	0.219526	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.00610732	0.219526	1
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Trichomonas vaginalis	conserved hypothetical protein	0.000972019	0.0126925	0.5
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.00610732	0.219526	0.544081
Echinococcus granulosus	neuropeptides capa receptor	0.00610732	0.219526	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.00610732	0.219526	1
Echinococcus multilocularis	fmrfamide receptor	0.00610732	0.219526	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.000972019	0.0126925	0.5
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.000972019	0.0126925	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.00610732	0.219526	1
Schistosoma mansoni	high-affinity cgmp-specific 35-cyclic phosphodiesterase	0.000972019	0.0126925	0.0578176
Plasmodium falciparum	phosphodiesterase gamma, putative	0.000972019	0.0126925	0.5
Echinococcus granulosus	dual 3'5' cyclic AMP and GMP phosphodiesterase	0.000972019	0.0126925	0.0578176
Brugia malayi	hypothetical protein	0.00610732	0.219526	0.544081
Schistosoma mansoni	calcium/calmodulin-dependent 35-cyclic nucleotide phosphodiesterase	0.000972019	0.0126925	0.0578176
Echinococcus multilocularis	neuropeptide Y receptor	0.00610732	0.219526	1
Echinococcus multilocularis	neuropeptide s receptor	0.00610732	0.219526	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.00610732	0.219526	1
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.000972019	0.0126925	0.5
Onchocerca volvulus		0.00974384	0.365993	0.941137
Schistosoma mansoni	amine GPCR	0.00610732	0.219526	1
Echinococcus granulosus	twitchin	0.000824644	0.00675668	0.0307785
Brugia malayi	hypothetical protein	0.00610732	0.219526	0.544081
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.00610732	0.219526	0.544081
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.00610732	0.219526	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.00610732	0.219526	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.00610732	0.219526	1
Schistosoma mansoni	neuropeptide receptor	0.00610732	0.219526	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.00610732	0.219526	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.00610732	0.219526	1
Plasmodium falciparum	phosphodiesterase delta, putative	0.000972019	0.0126925	0.5
Schistosoma mansoni	amine GPCR	0.00610732	0.219526	1
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.00610732	0.219526	1
Schistosoma mansoni	camp-specific 35-cyclic phosphodiesterase	0.000972019	0.0126925	0.0578176
Echinococcus granulosus	g protein coupled receptor	0.00610732	0.219526	1
Echinococcus granulosus	neuropeptide receptor	0.00610732	0.219526	1
Onchocerca volvulus	Tyrosine kinase homolog	0.00997128	0.375154	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.00610732	0.219526	1
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.000972019	0.0126925	0.0314575
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.000972019	0.0126925	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.00610732	0.219526	1
Echinococcus granulosus	roundabout 2	0.00103879	0.015382	0.0700691
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Echinococcus granulosus	rhodopsin orphan GPCR	0.00610732	0.219526	1
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.00610732	0.219526	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.00610732	0.219526	1
Echinococcus granulosus	hypothetical protein	0.00610732	0.219526	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.00610732	0.219526	1
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Brugia malayi	GnHR receptor homolog	0.00610732	0.219526	0.544081
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.00610732	0.219526	0.544081
Echinococcus granulosus	peptide allatostatin:somatostatin	0.00610732	0.219526	1
Echinococcus multilocularis	high affinity cAMP specific 3',5' cyclic	0.000972019	0.0126925	0.0578176
Echinococcus granulosus	dro:myosuppressin receptor	0.00610732	0.219526	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.000972019	0.0126925	0.5
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.00610732	0.219526	0.544081
Schistosoma mansoni	opsin-like receptor	0.00610732	0.219526	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.00610732	0.219526	1
Trichomonas vaginalis	cGMP-inhibited 3,5-cyclic phosphodiesterase, putative	0.000972019	0.0126925	0.5
Echinococcus granulosus	g protein coupled receptor	0.00610732	0.219526	1
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Schistosoma mansoni	histamine h1 receptor	0.00610732	0.219526	1
Echinococcus granulosus	calcium:calmodulin dependent 3'5' cyclic	0.000972019	0.0126925	0.0578176
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.00610732	0.219526	0.544081
Brugia malayi	Serotonin receptor	0.00610732	0.219526	0.544081
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.00610732	0.219526	1
Schistosoma mansoni	camp/cgmp cyclic nucleotide phosphodiesterase	0.000972019	0.0126925	0.0578176
Echinococcus multilocularis	neuropeptide FF receptor 2	0.00610732	0.219526	1
Schistosoma mansoni	hypothetical protein	0.00610732	0.219526	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.000972019	0.0126925	0.5
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.000972019	0.0126925	0.5
Echinococcus multilocularis	sex peptide receptor	0.00610732	0.219526	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.000972019	0.0126925	0.5
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Brugia malayi	Immunoglobulin I-set domain containing protein	0.0106746	0.40348	1
Loa Loa (eye worm)	calcium/calmodulin-stimulated cyclic nucleotide phosphodiesterase	0.000972019	0.0126925	0.0314575
Echinococcus granulosus	neuropeptide Y receptor	0.00610732	0.219526	1
Leishmania major	hypothetical protein, conserved	0.0254851	1	1
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.000972019	0.0126925	0.0314575
Giardia lamblia	Hypothetical protein	0.000972019	0.0126925	0.5
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase C32E12.2, putative	0.000972019	0.0126925	0.0314575
Schistosoma mansoni	biogenic amine (5HT) receptor	0.00610732	0.219526	1
Trichomonas vaginalis	calcium/calmodulin-dependent 3,5-cyclic nucleotide phosphodiesterase, putative	0.000972019	0.0126925	0.5
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.00610732	0.219526	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.000972019	0.0126925	0.5
Loa Loa (eye worm)	melatonin receptor type 1A	0.00610732	0.219526	0.544081
Loa Loa (eye worm)	hypothetical protein	0.00103879	0.015382	0.0381233
Echinococcus multilocularis	fmrfamide receptor	0.00610732	0.219526	1
Trichomonas vaginalis	rod cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.000972019	0.0126925	0.5
Trichomonas vaginalis	high-affinity cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.000972019	0.0126925	0.5
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Brugia malayi	hypothetical protein	0.00610732	0.219526	0.544081
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.00610732	0.219526	1
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Loa Loa (eye worm)	TK/KIN16 protein kinase	0.0106746	0.40348	1
Echinococcus granulosus	tm gpcr rhodopsin	0.00610732	0.219526	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.00610732	0.219526	1
Loa Loa (eye worm)	hypothetical protein	0.000972019	0.0126925	0.0314575
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Echinococcus multilocularis	neuroglian	0.000824644	0.00675668	0.0307785
Brugia malayi	hypothetical protein	0.00610732	0.219526	0.544081
Trichomonas vaginalis	cAMP/cGMP cyclic nucleotide phosphodiesterase, putative	0.000972019	0.0126925	0.5
Echinococcus granulosus	orexin receptor type 2	0.00610732	0.219526	1
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Trypanosoma cruzi	cyclic nucleotide phosphodiesterase	0.0254851	1	1
Echinococcus multilocularis	neuropeptide receptor	0.00610732	0.219526	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.00610732	0.219526	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.00610732	0.219526	1
Brugia malayi	3'5'-cyclic nucleotide phosphodiesterase family protein	0.000972019	0.0126925	0.0314575
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Trichomonas vaginalis	cGMP-dependent 3,5-cyclic phosphodiesterase, putative	0.000972019	0.0126925	0.5
Plasmodium vivax	3',5'-cyclic nucleotide phosphodiesterase, putative	0.000972019	0.0126925	0.5
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.000972019	0.0126925	0.0578176
Brugia malayi	G protein-coupled receptor F59B2.13	0.00610732	0.219526	0.544081
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.00610732	0.219526	1
Plasmodium falciparum	3',5'-cyclic nucleotide phosphodiesterase, putative	0.000972019	0.0126925	0.5
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.00610732	0.219526	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.00610732	0.219526	1
Schistosoma mansoni	biogenic amine receptor	0.00610732	0.219526	1
Toxoplasma gondii	3'5'-cyclic nucleotide phosphodiesterase domain-containing protein	0.000972019	0.0126925	0.5
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.000972019	0.0126925	0.5
Echinococcus multilocularis	roundabout 2	0.00103879	0.015382	0.0700691
Brugia malayi	Probable 3',5'-cyclic phosphodiesterase T04D3.3, putative	0.000972019	0.0126925	0.0314575
Echinococcus multilocularis	calcium:calmodulin dependent 3',5' cyclic	0.000972019	0.0126925	0.0578176
Echinococcus multilocularis	cAMP specific 3',5' cyclic phosphodiesterase	0.000972019	0.0126925	0.0578176
Echinococcus granulosus	sex peptide receptor	0.00610732	0.219526	1
Trichomonas vaginalis	cGMP-specific 3,5-cyclic phosphodiesterase, putative	0.000972019	0.0126925	0.5
Echinococcus granulosus	cAMP specific 3'5' cyclic phosphodiesterase	0.000972019	0.0126925	0.0578176
Trichomonas vaginalis	cyclic nucleotide phosphodiesterase, putative	0.000972019	0.0126925	0.5
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Loa Loa (eye worm)	hypothetical protein	0.00610732	0.219526	0.544081
Brugia malayi	larval opioid receptor	0.00610732	0.219526	0.544081

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (functional)	= 2.05 uM	Antimalarial activity against Plasmodium falciparum FCR3 after 48 hrs by parasite lactate dehydrogenase assay	ChEMBL.	25255435

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23	25255435

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL3338903

Bibliographic References

No literature references available for this target.

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Detailed information for compound 933777