Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein, conserved | 0.0028 | 0 | 0.5 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0014 | 0.0014 |
Plasmodium falciparum | importin beta, putative | 0.0029 | 0.0014 | 0.5 |
Leishmania major | lanosterol synthase, putative | 0.0695 | 0.9715 | 1 |
Plasmodium vivax | importin-beta 2, putative | 0.0029 | 0.0014 | 0.5 |
Echinococcus multilocularis | snurportin 1 | 0.0307 | 0.4068 | 1 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.0714 | 1 | 1 |
Echinococcus multilocularis | importin subunit beta 1 | 0.0029 | 0.0014 | 0.0036 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0307 | 0.4068 | 1 |
Brugia malayi | hypothetical protein | 0.0301 | 0.3987 | 1 |
Toxoplasma gondii | HEAT repeat-containing protein | 0.0029 | 0.0014 | 0.5 |
Echinococcus granulosus | importin subunit beta 1 | 0.0029 | 0.0014 | 0.0036 |
Schistosoma mansoni | importin beta-1 | 0.0029 | 0.0014 | 0.0036 |
Leishmania major | squalene monooxygenase-like protein | 0.0407 | 0.5529 | 0.5691 |
Schistosoma mansoni | hypothetical protein | 0.0083 | 0.08 | 0.1966 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0407 | 0.5529 | 0.5529 |
Giardia lamblia | Rrm3p helicase | 0.0028 | 0 | 0.5 |
Brugia malayi | RNA, U transporter 1 | 0.0082 | 0.0787 | 0.1945 |
Trypanosoma brucei | RNA helicase, putative | 0.0083 | 0.08 | 0.08 |
Schistosoma mansoni | hypothetical protein | 0.0307 | 0.4068 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0028 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0301 | 0.3987 | 0.9799 |
Onchocerca volvulus | 0.0301 | 0.3987 | 0.5 | |
Echinococcus granulosus | snurportin 1 | 0.0307 | 0.4068 | 1 |
Entamoeba histolytica | DNA repair and recombination protein, putative | 0.0028 | 0 | 0.5 |
Trypanosoma cruzi | squalene monooxygenase, putative | 0.0407 | 0.5529 | 0.5529 |
Mycobacterium tuberculosis | Halimadienyl diphosphate synthase | 0.0459 | 0.6281 | 0.5 |
Trypanosoma brucei | squalene monooxygenase, putative | 0.0407 | 0.5529 | 0.5529 |
Trypanosoma cruzi | lanosterol synthase, putative | 0.0714 | 1 | 1 |
Trypanosoma brucei | importin beta-1 subunit, putative | 0.0029 | 0.0014 | 0.0014 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.