Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | Cathepsin B precursor | 0.0262 | 0.2555 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0172 | 0.1142 | 0.4469 |
Echinococcus granulosus | cathepsin l1 | 0.0172 | 0.1142 | 0.1142 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.027 | 0.2683 | 0.2683 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0172 | 0.1142 | 0.1142 |
Plasmodium vivax | vivapain-2 | 0.0172 | 0.1142 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.027 | 0.2683 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0172 | 0.1142 | 0.4469 |
Giardia lamblia | Cathepsin B precursor | 0.0262 | 0.2555 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.1142 | 0.0808 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.027 | 0.2683 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0172 | 0.1142 | 0.4469 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0147 | 0.0762 | 0.0762 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0172 | 0.1142 | 0.4469 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.022 | 0.1904 | 0.1904 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.027 | 0.2683 | 0.2683 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0172 | 0.1142 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.0122 | 0.0363 | 0.0363 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0172 | 0.1142 | 0.1142 |
Echinococcus multilocularis | cysteine protease | 0.0172 | 0.1142 | 0.1142 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0172 | 0.1142 | 0.1142 |
Loa Loa (eye worm) | fibroinase | 0.0172 | 0.1142 | 0.0808 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0122 | 0.0363 | 0.0363 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0172 | 0.1142 | 0.4469 |
Onchocerca volvulus | 0.0172 | 0.1142 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0172 | 0.1142 | 0.4469 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0172 | 0.1142 | 0.4469 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0172 | 0.1142 | 0.1142 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0172 | 0.1142 | 0.4469 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.027 | 0.2683 | 1 |
Leishmania major | cathepsin L-like protease | 0.027 | 0.2683 | 1 |
Onchocerca volvulus | 0.0172 | 0.1142 | 1 | |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0172 | 0.1142 | 0.1142 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.027 | 0.2683 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0172 | 0.1142 | 0.1142 |
Brugia malayi | Cathepsin L-like precursor | 0.0122 | 0.0363 | 0.0363 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.027 | 0.2683 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0172 | 0.1142 | 0.4469 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0172 | 0.1142 | 0.4469 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0172 | 0.1142 | 0.4469 |
Leishmania major | cathepsin L-like protease | 0.027 | 0.2683 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0122 | 0.0363 | 0.1422 |
Brugia malayi | Cathepsin L-like precursor | 0.0172 | 0.1142 | 0.1142 |
Brugia malayi | Cathepsin L-like precursor | 0.0172 | 0.1142 | 0.1142 |
Onchocerca volvulus | 0.0172 | 0.1142 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0172 | 0.1142 | 0.4469 |
Onchocerca volvulus | 0.0172 | 0.1142 | 1 | |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0122 | 0.0363 | 0.0363 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0172 | 0.1142 | 0.4469 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0172 | 0.1142 | 0.1142 |
Echinococcus multilocularis | cysteine protease | 0.0172 | 0.1142 | 0.1142 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0172 | 0.1142 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0172 | 0.1142 | 0.0808 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0262 | 0.2555 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0262 | 0.2555 | 0.2274 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0262 | 0.2555 | 0.2555 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.027 | 0.2683 | 0.2683 |
Brugia malayi | Cathepsin L-like precursor | 0.0172 | 0.1142 | 0.1142 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0172 | 0.1142 | 0.0808 |
Toxoplasma gondii | cathepsin B | 0.0262 | 0.2555 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0737 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0172 | 0.1142 | 0.4469 |
Onchocerca volvulus | Cathepsin L homolog | 0.0172 | 0.1142 | 1 |
Onchocerca volvulus | 0.0172 | 0.1142 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0172 | 0.1142 | 0.4469 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0172 | 0.1142 | 0.1142 |
Echinococcus multilocularis | cathepsin b | 0.0737 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0737 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.027 | 0.2683 | 1 |
Echinococcus granulosus | cathepsin b | 0.0737 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.027 | 0.2683 | 0.2683 |
Brugia malayi | Cathepsin L-like precursor | 0.0122 | 0.0363 | 0.0363 |
Onchocerca volvulus | Cathepsin F homolog | 0.0172 | 0.1142 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.027 | 0.2683 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0262 | 0.2555 | 0.2555 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0172 | 0.1142 | 0.4469 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.027 | 0.2683 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0172 | 0.1142 | 0.4469 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0262 | 0.2555 | 0.9172 |
Onchocerca volvulus | 0.0172 | 0.1142 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0122 | 0.0363 | 0.1422 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.027 | 0.2683 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0172 | 0.1142 | 0.4469 |
Echinococcus granulosus | cathepsin b | 0.0737 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0172 | 0.1142 | 0.4469 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0737 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0172 | 0.1142 | 0.4469 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0737 | 1 | 1 |
Echinococcus multilocularis | cathepsin b | 0.0737 | 1 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0737 | 1 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0172 | 0.1142 | 0.1142 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0172 | 0.1142 | 0.1142 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0172 | 0.1142 | 0.1142 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0172 | 0.1142 | 0.4469 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.027 | 0.2683 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0172 | 0.1142 | 0.4469 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0172 | 0.1142 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0122 | 0.0363 | 0.3182 |
Loa Loa (eye worm) | ctsf protein | 0.0172 | 0.1142 | 0.0808 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0172 | 0.1142 | 0.4469 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0172 | 0.1142 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0172 | 0.1142 | 0.1142 |
Onchocerca volvulus | Cathepsin L homolog | 0.0172 | 0.1142 | 1 |
Leishmania major | cathepsin L-like protease | 0.027 | 0.2683 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0172 | 0.1142 | 0.4469 |
Loa Loa (eye worm) | cysteine protease | 0.0172 | 0.1142 | 0.0808 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.027 | 0.2683 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0262 | 0.2555 | 0.9524 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0737 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0172 | 0.1142 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0172 | 0.1142 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0262 | 0.2555 | 0.5 |
Plasmodium vivax | vivapain-2 | 0.0172 | 0.1142 | 1 |
Onchocerca volvulus | 0.0172 | 0.1142 | 1 | |
Echinococcus granulosus | cathepsin l1 | 0.0122 | 0.0363 | 0.0363 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0172 | 0.1142 | 0.4469 |
Brugia malayi | Cathepsin L-like precursor | 0.0172 | 0.1142 | 0.1142 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 240 mg kg-1 | Effective dose in mice by maximal electroshock assay, administered orally | ChEMBL. | 3746810 |
ED50 (functional) | > 400 mg kg-1 | Effective dose in mice by pentylenetetrazole assay (administered subcutaneously) | ChEMBL. | 3746810 |
TPE (functional) | = 1 hr | Compound was tested for time to peak anticonvulsant effect (TPE) | ChEMBL. | 3746810 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.