Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0107 | 0.2277 | 1 |
Mycobacterium ulcerans | amidase | 0.0013 | 0.0054 | 0.0054 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0107 | 0.2277 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0107 | 0.2277 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0107 | 0.2277 | 1 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0073 | 0.1479 | 0.5 |
Treponema pallidum | hypothetical protein | 0.0043 | 0.0773 | 1 |
Plasmodium vivax | PST-A protein | 0.0073 | 0.1479 | 1 |
Mycobacterium ulcerans | lysophospholipase | 0.0073 | 0.1479 | 0.1479 |
Mycobacterium tuberculosis | Probable amidase AmiC (aminohydrolase) | 0.0013 | 0.0054 | 0.0054 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0073 | 0.1479 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0107 | 0.2277 | 1 |
Mycobacterium ulcerans | peptide amidase, GatA | 0.0013 | 0.0054 | 0.0054 |
Plasmodium falciparum | esterase, putative | 0.0073 | 0.1479 | 1 |
Mycobacterium tuberculosis | Possible lysophospholipase | 0.0079 | 0.1605 | 0.1605 |
Mycobacterium ulcerans | amidase | 0.0013 | 0.0054 | 0.0054 |
Mycobacterium tuberculosis | Conserved protein | 0.005 | 0.0934 | 0.0934 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0073 | 0.1479 | 0.5 |
Mycobacterium tuberculosis | Probable amidase AmiB2 (aminohydrolase) | 0.0013 | 0.0054 | 0.0054 |
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.2277 | 1 |
Echinococcus granulosus | patatin phospholipase domain containing protein | 0.005 | 0.0934 | 0.3959 |
Brugia malayi | amidase | 0.0107 | 0.2277 | 1 |
Schistosoma mansoni | neuropathy target esterase/swiss cheese-related protein | 0.0046 | 0.0844 | 0.3554 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.0934 | 0.3959 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0073 | 0.1479 | 1 |
Mycobacterium ulcerans | amidase | 0.0013 | 0.0054 | 0.0054 |
Trypanosoma cruzi | monoglyceride lipase, putative | 0.0073 | 0.1479 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0073 | 0.1479 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0073 | 0.1479 | 0.5 |
Mycobacterium ulcerans | amidase | 0.0013 | 0.0054 | 0.0054 |
Mycobacterium tuberculosis | Probable amidase AmiA2 (aminohydrolase) | 0.0013 | 0.0054 | 0.0054 |
Plasmodium falciparum | lysophospholipase, putative | 0.0073 | 0.1479 | 1 |
Mycobacterium ulcerans | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD | 0.0434 | 1 | 1 |
Brugia malayi | Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative | 0.005 | 0.0934 | 0.3959 |
Plasmodium falciparum | lysophospholipase, putative | 0.0073 | 0.1479 | 1 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0013 | 0.0054 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0073 | 0.1479 | 0.5 |
Schistosoma mansoni | neuropathy target esterase/swiss cheese-related protein | 0.0046 | 0.0844 | 0.3554 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0073 | 0.1479 | 0.5 |
Plasmodium falciparum | lysophospholipase, putative | 0.0073 | 0.1479 | 1 |
Mycobacterium leprae | POSSIBLE LYSOPHOSPHOLIPASE | 0.0079 | 0.1605 | 1 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.0013 | 0.0054 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0073 | 0.1479 | 0.1479 |
Leishmania major | monoglyceride lipase, putative | 0.0073 | 0.1479 | 1 |
Mycobacterium tuberculosis | Probable amidase AmiD (acylamidase) (acylase) | 0.0013 | 0.0054 | 0.0054 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0073 | 0.1479 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0073 | 0.1479 | 0.5 |
Mycobacterium ulcerans | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.0013 | 0.0054 | 0.0054 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0073 | 0.1479 | 1 |
Schistosoma mansoni | amidase | 0.0107 | 0.2277 | 1 |
Mycobacterium tuberculosis | Possible amidase (aminohydrolase) | 0.0013 | 0.0054 | 0.0054 |
Onchocerca volvulus | 0.005 | 0.0934 | 0.5 | |
Mycobacterium ulcerans | amidase | 0.0013 | 0.0054 | 0.0054 |
Echinococcus multilocularis | patatin phospholipase domain containing protein | 0.005 | 0.0934 | 0.3959 |
Trichomonas vaginalis | valacyclovir hydrolase, putative | 0.0073 | 0.1479 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 821 uM | Cytotoxicity against human MCF7 cells after 24 hrs by MTT assay | ChEMBL. | 25438754 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.