Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 0.4917 | 0.4917 |
Schistosoma mansoni | nuclear hormone receptor | 0.0232 | 0.4307 | 0.4191 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0491 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0259 | 0.4917 | 0.4856 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0491 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.4307 | 0.4307 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0491 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0232 | 0.4307 | 0.4239 |
Brugia malayi | hypothetical protein | 0.0232 | 0.4307 | 0.4239 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0259 | 0.4917 | 0.4813 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0491 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0232 | 0.4307 | 0.4191 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.4307 | 0.4307 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0491 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0491 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0491 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.4307 | 0.4307 |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0491 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0491 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.4307 | 0.4307 |
Schistosoma mansoni | nuclear receptor | 0.0232 | 0.4307 | 0.4191 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.4307 | 0.4307 |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0491 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0491 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0491 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0491 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0232 | 0.4307 | 0.4239 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0232 | 0.4307 | 0.4307 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0232 | 0.4307 | 0.4239 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0232 | 0.4307 | 0.4239 |
Brugia malayi | nuclear receptor NHR-88 | 0.0232 | 0.4307 | 0.4239 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0491 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.4307 | 0.4307 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0232 | 0.4307 | 0.4239 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0038 | 0.0059 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 1 | 1 |
Brugia malayi | tailless protein | 0.0232 | 0.4307 | 0.4239 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0041 | 0.0118 | 0.0118 |
Brugia malayi | nuclear receptor NHR-88 | 0.0491 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0491 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0232 | 0.4307 | 0.4239 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0232 | 0.4307 | 0.4239 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0491 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0491 | 1 | 1 |
Brugia malayi | ecdysone receptor | 0.0232 | 0.4307 | 0.4239 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0491 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.4307 | 0.4307 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0232 | 0.4307 | 0.4191 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.4307 | 0.4307 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0232 | 0.4307 | 0.4239 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.4307 | 0.4307 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0232 | 0.4307 | 0.4307 |
Brugia malayi | nuclear receptor RXR | 0.0232 | 0.4307 | 0.4239 |
Schistosoma mansoni | nuclear receptor | 0.0232 | 0.4307 | 0.4191 |
Loa Loa (eye worm) | DR-78 | 0.0232 | 0.4307 | 0.4307 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0491 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0491 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0491 | 1 | 1 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0491 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0491 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0491 | 1 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0232 | 0.4307 | 0.4191 |
Schistosoma mansoni | nuclear hormone receptor | 0.0491 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 0.4917 | 0.4917 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0232 | 0.4307 | 0.4239 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0259 | 0.4917 | 0.4856 |
Brugia malayi | nuclear receptor NHR-67 | 0.0232 | 0.4307 | 0.4239 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.4307 | 0.4307 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0491 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0491 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0491 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.4307 | 0.4307 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0491 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0491 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0491 | 1 | 1 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0259 | 0.4917 | 0.4813 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0232 | 0.4307 | 0.4239 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0491 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0491 | 1 | 1 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0491 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0491 | 1 | 1 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0232 | 0.4307 | 0.4239 |
Schistosoma mansoni | thyroid hormone receptor | 0.0491 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0491 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0491 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0491 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0491 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0232 | 0.4307 | 0.4239 |
Onchocerca volvulus | 0.0491 | 1 | 1 | |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0232 | 0.4307 | 0.4239 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0259 | 0.4917 | 0.4856 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0491 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0491 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0259 | 0.4917 | 0.4856 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0491 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0259 | 0.4917 | 0.4917 |
Brugia malayi | conserved hypotetical protein | 0.0232 | 0.4307 | 0.4239 |
Brugia malayi | hypothetical protein | 0.0259 | 0.4917 | 0.4856 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0491 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0491 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0491 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0491 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0491 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0491 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0259 | 0.4917 | 0.4856 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.4307 | 0.4307 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0491 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0491 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 0.4917 | 0.4917 |
Brugia malayi | hypothetical protein | 0.0259 | 0.4917 | 0.4856 |
Loa Loa (eye worm) | hypothetical protein | 0.0232 | 0.4307 | 0.4307 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0491 | 1 | 1 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0232 | 0.4307 | 0.4239 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0232 | 0.4307 | 0.4239 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0232 | 0.4307 | 0.4307 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 0.4917 | 0.4917 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0232 | 0.4307 | 0.4239 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0232 | 0.4307 | 0.4239 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0491 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0491 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0491 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0232 | 0.4307 | 0.4239 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0491 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0491 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0232 | 0.4307 | 0.4239 |
Loa Loa (eye worm) | hypothetical protein | 0.0259 | 0.4917 | 0.4917 |
Brugia malayi | nuclear hormone receptor | 0.0232 | 0.4307 | 0.4239 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0491 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0038 | 0.0059 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0491 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0491 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0491 | 1 | 1 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0232 | 0.4307 | 0.4191 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0232 | 0.4307 | 0.4191 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 28 % | Displacement of [3H]E1 from human placental cytosolic17beta-HSD1 at 1 uM after 10 mins by cell-free assay | ChEMBL. | 25259513 |
Inhibition (binding) | = 56 % | Displacement of [3H]E2 from human placental microsomal 17beta-HSD2 at 1 uM after 20 mins by cell-free assay | ChEMBL. | 25259513 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.