Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | aurora kinase B | Starlite/ChEMBL | References |
Escherichia coli | fused N-acetyl glucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyl transferase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | aurora kinase B | 303 aa | 299 aa | 22.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0404 | 0.4773 | 1 | |
Wolbachia endosymbiont of Brugia malayi | N-acetylglucosamine-1-phosphate uridyltransferase | 0.0684 | 1 | 0.5 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0673 | 0.9788 | 1 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0673 | 0.9788 | 1 |
Onchocerca volvulus | 0.0404 | 0.4773 | 1 | |
Onchocerca volvulus | 0.0404 | 0.4773 | 1 | |
Onchocerca volvulus | 0.0404 | 0.4773 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0404 | 0.4773 | 1 |
Brugia malayi | LBP/BPI | 0.0172 | 0.0461 | 0.0967 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.1564 | 0.3276 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0673 | 0.9788 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.0461 | 0.0967 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.1564 | 0.3276 |
Onchocerca volvulus | 0.0404 | 0.4773 | 1 | |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0404 | 0.4773 | 1 |
Brugia malayi | hypothetical protein | 0.0172 | 0.0461 | 0.0967 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0231 | 0.1564 | 0.3276 |
Mycobacterium tuberculosis | Probable UDP-N-acetylglucosamine pyrophosphorylase GlmU | 0.0684 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.0461 | 0.0967 |
Onchocerca volvulus | 0.0172 | 0.0461 | 0.0967 | |
Mycobacterium ulcerans | bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase | 0.0684 | 1 | 0.5 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0231 | 0.1564 | 0.3276 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0172 | 0.0461 | 0.5 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0231 | 0.1564 | 0.3276 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0231 | 0.1564 | 0.3276 |
Brugia malayi | hypothetical protein | 0.0231 | 0.1564 | 0.3276 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0231 | 0.1564 | 0.3276 |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.0461 | 0.0967 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.1564 | 0.3276 |
Onchocerca volvulus | 0.0231 | 0.1564 | 0.3276 | |
Onchocerca volvulus | 0.0404 | 0.4773 | 1 | |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0404 | 0.4773 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.1564 | 0.3276 |
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0404 | 0.4773 | 1 |
Brugia malayi | hypothetical protein | 0.0231 | 0.1564 | 0.3276 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0404 | 0.4773 | 1 |
Onchocerca volvulus | 0.0404 | 0.4773 | 1 | |
Onchocerca volvulus | 0.0231 | 0.1564 | 0.3276 | |
Loa Loa (eye worm) | hypothetical protein | 0.0231 | 0.1564 | 0.3276 |
Onchocerca volvulus | 0.0404 | 0.4773 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0172 | 0.0461 | 0.0967 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.689 uM | Inhibition of human AURKB incubated for 20 mins prior to MgCl2 addition measured after 90 mins by mobility shift assay | ChEMBL. | 25262942 |
IC50 (binding) | = 6.7 uM | Inhibition of Escherichia coli ATCC 27325 GlmU expressed in Escherichia coli HMS174(DE3) incubated for 15 mins prior to MgCl2 addition measured after 30 mins by malachite green staining-based assay | ChEMBL. | 25262942 |
IC50 (binding) | > 30 uM | Inhibition of human IRAK4 incubated for 20 mins prior to MgCl2 addition measured after 90 mins by mobility shift assay | ChEMBL. | 25262942 |
IC50 (binding) | > 30 uM | Inhibition of human IRAK1 incubated for 20 mins prior to MgCl2 addition measured after 90 mins by mobility shift assay | ChEMBL. | 25262942 |
IC50 (binding) | > 30 uM | Inhibition of human JAK1 incubated for 20 mins prior to MgCl2 addition measured after 90 mins by mobility shift assay | ChEMBL. | 25262942 |
IC50 (binding) | > 30 uM | Inhibition of human JAK2 incubated for 20 mins prior to MgCl2 addition measured after 90 mins by mobility shift assay | ChEMBL. | 25262942 |
IC50 (binding) | > 30 uM | Inhibition of human JAK3 incubated for 20 mins prior to MgCl2 addition measured after 90 mins by mobility shift assay | ChEMBL. | 25262942 |
IC50 (binding) | > 30 uM | Inhibition of human CDK1 incubated for 20 mins prior to MgCl2 addition measured after 90 mins by mobility shift assay | ChEMBL. | 25262942 |
IC50 (binding) | > 30 uM | Inhibition of human CDK2 incubated for 20 mins prior to MgCl2 addition measured after 90 mins by mobility shift assay | ChEMBL. | 25262942 |
IC50 (binding) | > 30 uM | Inhibition of human CDK9 incubated for 20 mins prior to MgCl2 addition measured after 90 mins by mobility shift assay | ChEMBL. | 25262942 |
PB (ADMET) | > 99 % | Serum protein binding in human at 10 uM after 30 mins by ultrafiltration method | ChEMBL. | 25262942 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.