Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin D2 receptor 2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0134 | 0.6804 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0134 | 0.6804 | 1 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.0134 | 0.6804 | 1 |
Schistosoma mansoni | 3-oxoacyl-[ACP] reductase | 0.0013 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | enoyl-ACP reductase | 0.0191 | 1 | 1 |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Mycobacterium tuberculosis | NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) | 0.0191 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0134 | 0.6804 | 1 |
Plasmodium vivax | enoyl-acyl carrier protein reductase | 0.0191 | 1 | 1 |
Mycobacterium leprae | NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) | 0.0191 | 1 | 1 |
Mycobacterium ulcerans | enoyl-(acyl carrier protein) reductase | 0.0191 | 1 | 1 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.0134 | 0.6804 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0134 | 0.6804 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.0134 | 0.6804 | 1 |
Onchocerca volvulus | 0.0013 | 0 | 0.5 | |
Plasmodium falciparum | enoyl-acyl carrier reductase | 0.0191 | 1 | 1 |
Trichomonas vaginalis | hypothetical protein | 0.0191 | 1 | 0.5 |
Schistosoma mansoni | dihydropteridine reductase | 0.0013 | 0 | 0.5 |
Entamoeba histolytica | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0013 | 0 | 0.5 |
Toxoplasma gondii | enoyl-acyl carrier reductase ENR | 0.0191 | 1 | 1 |
Brugia malayi | P38 map kinase family protein 2 | 0.0134 | 0.6804 | 1 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0134 | 0.6804 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0134 | 0.6804 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0134 | 0.6804 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0134 | 0.6804 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 5.8 nM | Antagonist activity at CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as inhibition of [35S]-GTPgammaS binding measured after 2 hrs by liquid scintillation counting analysis | ChEMBL. | 25437505 |
IC50 (binding) | = 6.7 nM | Antagonist activity at CRTh2 receptor in human whole blood assessed as inhibition of PGD2-induced eosinophil shape change preincubated for 10 mins with PGD2 addition measured after 4 mins by forward scatter and side scatter analysis | ChEMBL. | 25437505 |
T1/2 (functional) | = 16 hr | Binding affinity to CRTh2 receptor (unknown origin) overexpressed in CHOK1 cell membranes assessed as dissociation half life at 10 times IC50 concentration preincubated for 1 hr with 0.1 nM to 100 uM PGD2 and [35S]-GTPgammaS by liquid scintillation counting analysis | ChEMBL. | 25437505 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.