Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Cathepsin L-like precursor | 0.0123 | 0.1027 | 0.1027 |
Brugia malayi | Cathepsin L-like precursor | 0.0123 | 0.1027 | 0.1027 |
Onchocerca volvulus | 0.0123 | 0.1027 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0123 | 0.1027 | 0.3938 |
Brugia malayi | Cathepsin L-like precursor | 0.0088 | 0.0327 | 0.0327 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0123 | 0.1027 | 0.1027 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0123 | 0.1027 | 0.3938 |
Onchocerca volvulus | 0.0123 | 0.1027 | 1 | |
Echinococcus multilocularis | cysteine protease | 0.0123 | 0.1027 | 0.1027 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0123 | 0.1027 | 1 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0123 | 0.1027 | 0.0724 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0169 | 0.1942 | 0.7445 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0169 | 0.1942 | 0.7445 |
Leishmania major | cathepsin L-like protease | 0.0169 | 0.1942 | 0.5786 |
Brugia malayi | Cathepsin L-like precursor | 0.0123 | 0.1027 | 0.1027 |
Toxoplasma gondii | cathepsin B | 0.0203 | 0.2609 | 1 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0123 | 0.1027 | 0.0724 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0169 | 0.1942 | 0.7445 |
Loa Loa (eye worm) | hypothetical protein | 0.0575 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0123 | 0.1027 | 0.3938 |
Onchocerca volvulus | Cathepsin L homolog | 0.0123 | 0.1027 | 1 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0169 | 0.1942 | 0.1942 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0203 | 0.2609 | 1 |
Onchocerca volvulus | 0.0123 | 0.1027 | 1 | |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0123 | 0.1027 | 0.1027 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0203 | 0.2609 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0123 | 0.1027 | 0.1027 |
Brugia malayi | cathepsin L-like precursor | 0.0088 | 0.0327 | 0.0327 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0169 | 0.1942 | 0.1942 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0123 | 0.1027 | 0.3938 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0123 | 0.1027 | 0.3938 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0123 | 0.1027 | 0.3938 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.0088 | 0.0327 | 0.0327 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0203 | 0.2609 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0123 | 0.1027 | 0.3938 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0088 | 0.0327 | 0.0327 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0123 | 0.1027 | 0.3938 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0134 | 0.1242 | 0.1242 |
Giardia lamblia | Cathepsin B precursor | 0.0203 | 0.2609 | 0.5 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0088 | 0.0327 | 0.1253 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0123 | 0.1027 | 1 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0123 | 0.1027 | 0.1027 |
Echinococcus multilocularis | cysteine protease | 0.0123 | 0.1027 | 0.1027 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0123 | 0.1027 | 0.1027 |
Loa Loa (eye worm) | fibroinase | 0.0123 | 0.1027 | 0.0724 |
Echinococcus granulosus | cathepsin l1 | 0.0088 | 0.0327 | 0.0327 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0123 | 0.1027 | 0.3938 |
Onchocerca volvulus | 0.0123 | 0.1027 | 1 | |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0123 | 0.1027 | 0.1027 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0123 | 0.1027 | 0.3938 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0123 | 0.1027 | 0.3938 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0123 | 0.1027 | 0.3938 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0169 | 0.1942 | 0.7445 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0123 | 0.1027 | 0.3938 |
Echinococcus granulosus | cathepsin l1 | 0.0123 | 0.1027 | 0.1027 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0123 | 0.1027 | 0.1027 |
Giardia lamblia | Cathepsin B precursor | 0.0203 | 0.2609 | 0.5 |
Plasmodium vivax | vivapain-2 | 0.0123 | 0.1027 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0169 | 0.1942 | 0.7445 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0169 | 0.1942 | 0.7445 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0123 | 0.1027 | 0.3938 |
Loa Loa (eye worm) | hypothetical protein | 0.0123 | 0.1027 | 0.0724 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0169 | 0.1942 | 0.7445 |
Loa Loa (eye worm) | cysteine protease | 0.0123 | 0.1027 | 0.0724 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0169 | 0.1942 | 0.7445 |
Leishmania major | cathepsin L-like protease | 0.0169 | 0.1942 | 0.5786 |
Echinococcus multilocularis | cathepsin b | 0.0575 | 1 | 1 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0123 | 0.1027 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0123 | 0.1027 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0169 | 0.1942 | 0.7445 |
Plasmodium vivax | vivapain-2 | 0.0123 | 0.1027 | 1 |
Onchocerca volvulus | 0.0123 | 0.1027 | 1 | |
Entamoeba histolytica | cysteine proteinase, putative | 0.0088 | 0.0327 | 0.3182 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0123 | 0.1027 | 0.3938 |
Brugia malayi | Cathepsin L-like precursor | 0.0123 | 0.1027 | 0.1027 |
Brugia malayi | Cathepsin L-like precursor | 0.0123 | 0.1027 | 0.1027 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0123 | 0.1027 | 0.1027 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0123 | 0.1027 | 0.1027 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0123 | 0.1027 | 0.3938 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0203 | 0.2609 | 0.2609 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0123 | 0.1027 | 0.3938 |
Loa Loa (eye worm) | ctsf protein | 0.0123 | 0.1027 | 0.0724 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0088 | 0.0327 | 0.1253 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0123 | 0.1027 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0123 | 0.1027 | 0.3938 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0123 | 0.1027 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0123 | 0.1027 | 0.1027 |
Onchocerca volvulus | Cathepsin L homolog | 0.0123 | 0.1027 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0203 | 0.2609 | 0.2609 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0123 | 0.1027 | 0.3938 |
Leishmania major | cathepsin L-like protease | 0.0169 | 0.1942 | 0.5786 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0123 | 0.1027 | 0.3938 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0123 | 0.1027 | 0.3938 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0169 | 0.1942 | 0.7445 |
Onchocerca volvulus | 0.0123 | 0.1027 | 1 | |
Brugia malayi | Cathepsin L-like precursor | 0.0088 | 0.0327 | 0.0327 |
Loa Loa (eye worm) | cathepsin B | 0.0203 | 0.2609 | 0.2359 |
Echinococcus granulosus | cathepsin b | 0.0575 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0123 | 0.1027 | 0.3938 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0123 | 0.1027 | 0.3938 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0575 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0123 | 0.1027 | 0.3938 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0575 | 1 | 1 |
Echinococcus granulosus | cathepsin b | 0.0575 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0575 | 1 | 1 |
Onchocerca volvulus | 0.0123 | 0.1027 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0123 | 0.1027 | 0.3938 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0123 | 0.1027 | 0.1027 |
Echinococcus multilocularis | cathepsin b | 0.0575 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0169 | 0.1942 | 0.1942 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0575 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0575 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0203 | 0.2609 | 0.5 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0082 | 0.0215 | 0.0215 |
Onchocerca volvulus | Cathepsin F homolog | 0.0123 | 0.1027 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0169 | 0.1942 | 0.1942 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0169 | 0.1942 | 0.7445 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | = 0.049 uM | Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTS assay | ChEMBL. | 25262050 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.