Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Influenza A virus (strain A/USSR/90/1977 H1N1) | Neuraminidase | Starlite/ChEMBL | References |
Influenza A virus | Neuraminidase | Starlite/ChEMBL | References |
Influenza A virus | Neuraminidase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0277 | 0.2228 | 0.1219 |
Mycobacterium ulcerans | aminopeptidase N PepN | 0.0214 | 0.1148 | 1 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0281 | 0.2289 | 0.1289 |
Schistosoma mansoni | family S28 unassigned peptidase (S28 family) | 0.0366 | 0.376 | 1 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0281 | 0.2289 | 0.2174 |
Echinococcus granulosus | Lysosomal Pro X carboxypeptidase | 0.0366 | 0.376 | 0.2951 |
Onchocerca volvulus | 0.0728 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0514 | 0.6307 | 0.7249 |
Loa Loa (eye worm) | hypothetical protein | 0.0653 | 0.8702 | 1 |
Echinococcus multilocularis | aminopeptidase N | 0.0728 | 1 | 1 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0169 | 0.0371 | 0.5 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0277 | 0.2228 | 1 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0277 | 0.2228 | 0.4133 |
Entamoeba histolytica | aminopeptidase, putative | 0.0214 | 0.1148 | 1 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0277 | 0.2228 | 1 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0214 | 0.1148 | 1 |
Echinococcus granulosus | aminopeptidase N | 0.0728 | 1 | 1 |
Giardia lamblia | Low molecular weight protein-tyrosine-phosphatase | 0.0156 | 0.0147 | 0.5 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0277 | 0.2228 | 1 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0281 | 0.2289 | 0.4368 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0277 | 0.2228 | 1 |
Loa Loa (eye worm) | phosphotyrosine protein phosphatase | 0.0156 | 0.0147 | 0.0169 |
Mycobacterium tuberculosis | Phosphotyrosine protein phosphatase PtpA (protein-tyrosine-phosphatase) (PTPase) (LMW phosphatase) | 0.0156 | 0.0147 | 0.5 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.0589 | 0.7606 | 0.874 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0277 | 0.2228 | 0.1219 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0281 | 0.2289 | 0.2174 |
Brugia malayi | hypothetical protein | 0.0214 | 0.1148 | 0.1016 |
Brugia malayi | Peptidase family M1 containing protein | 0.0214 | 0.1148 | 0.1016 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0277 | 0.2228 | 0.2112 |
Loa Loa (eye worm) | aminopeptidase N | 0.0214 | 0.1148 | 0.132 |
Onchocerca volvulus | 0.0214 | 0.1148 | 0.1016 | |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0281 | 0.2289 | 0.2631 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0281 | 0.2289 | 0.1289 |
Trypanosoma brucei | RNA helicase, putative | 0.0273 | 0.2154 | 0.9317 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0277 | 0.2228 | 1 |
Trichomonas vaginalis | Clan MA, family M1, aminopeptidase N-like metallopeptidase | 0.0214 | 0.1148 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0273 | 0.2154 | 0.3851 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.0366 | 0.376 | 0.2951 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.027 uM | Inhibition of Influenza A virus A/chicken/china/1220/2012(H5N1) Neuraminidase N1 | ChEMBL. | 25255388 |
IC50 (binding) | = 0.043 uM | Inhibition of Influenza A virus A/duck/china/1206/2012(H5N1) Neuraminidase | ChEMBL. | 25255388 |
IC50 (binding) | = 0.07 uM | Inhibition of Influenza A virus A/chicken/shandong/S2/02(H9N2) Neuraminidase | ChEMBL. | 25255388 |
IC50 (binding) | = 0.3 uM | Inhibition of Influenza A virus A/chicken/china/415/2013(H9N2) Neuraminidase N2 | ChEMBL. | 25255388 |
IC50 (binding) | = 0.54 uM | Inhibition of Influenza A virus A/duck/china/QJ/01(H5N1) Neuraminidase | ChEMBL. | 25255388 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.