Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase IX | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase XII | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | carbonic anhydrase-like protein | carbonic anhydrase I | 261 aa | 281 aa | 25.3 % |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | carbonic anhydrase XII | 354 aa | 295 aa | 23.1 % |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | carbonic anhydrase II | 260 aa | 259 aa | 32.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | AGC family protein kinase | 0.035 | 1 | 1 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.0233 | 0.4591 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0189 | 0.2517 | 0.4785 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0248 | 0.526 | 0.526 |
Brugia malayi | Protein kinase domain containing protein | 0.035 | 1 | 1 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0233 | 0.4591 | 0.8727 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.0229 | 0.439 | 0.8346 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.035 | 1 | 1 |
Echinococcus granulosus | nervana 2 | 0.0229 | 0.439 | 0.8346 |
Trichomonas vaginalis | AGC family protein kinase | 0.035 | 1 | 1 |
Giardia lamblia | Kinase, AGC PKA | 0.0233 | 0.4591 | 0.5 |
Entamoeba histolytica | protein kinase 2, putative | 0.0233 | 0.4591 | 0.2772 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.0233 | 0.4591 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0189 | 0.2517 | 0.2517 |
Trichomonas vaginalis | AGC family protein kinase | 0.035 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.0248 | 0.526 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.035 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.035 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0248 | 0.526 | 1 |
Echinococcus multilocularis | nervana 2 | 0.0229 | 0.439 | 0.8346 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0189 | 0.2517 | 0.2517 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.035 | 1 | 1 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0233 | 0.4591 | 0.8727 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0233 | 0.4591 | 0.2772 |
Entamoeba histolytica | protein kinase, putative | 0.035 | 1 | 1 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0233 | 0.4591 | 0.8727 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0.526 | 1 |
Loa Loa (eye worm) | AGC/PDK1 protein kinase | 0.0189 | 0.2517 | 0.2517 |
Leishmania major | carbonic anhydrase-like protein | 0.0248 | 0.526 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0248 | 0.526 | 0.526 |
Toxoplasma gondii | AGC kinase | 0.035 | 1 | 1 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0233 | 0.4591 | 0.8727 |
Brugia malayi | phosphoinositide-dependent protein kinase I | 0.0189 | 0.2517 | 0.2517 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0233 | 0.4591 | 0.2772 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0233 | 0.4591 | 0.8727 |
Echinococcus granulosus | 3-phosphoinositide-dependent protein kinase 1 | 0.0189 | 0.2517 | 0.4785 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0233 | 0.4591 | 0.8727 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.0229 | 0.439 | 0.8346 |
Trichomonas vaginalis | AGC family protein kinase | 0.035 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0248 | 0.526 | 1 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0233 | 0.4591 | 0.8727 |
Trichomonas vaginalis | AGC family protein kinase | 0.035 | 1 | 1 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.035 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.035 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0248 | 0.526 | 1 |
Echinococcus multilocularis | 3 phosphoinositide dependent protein kinase 1 | 0.0189 | 0.2517 | 0.4785 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0248 | 0.526 | 0.526 |
Trichomonas vaginalis | AGC family protein kinase | 0.035 | 1 | 1 |
Echinococcus granulosus | nervana 2 | 0.0229 | 0.439 | 0.8346 |
Echinococcus multilocularis | nervana 2 | 0.0229 | 0.439 | 0.8346 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0248 | 0.526 | 0.526 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0248 | 0.526 | 1 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0229 | 0.439 | 0.8346 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0229 | 0.439 | 0.8346 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 197 nM | Inhibition of human CA-9 after 15 mins by stopped-flow CO2 hydration method | ChEMBL. | 25267005 |
Ki (binding) | = 614 nM | Inhibition of human CA-12 after 15 mins by stopped-flow CO2 hydration method | ChEMBL. | 25267005 |
Ki (binding) | = 664 nM | Inhibition of human CA-2 after 15 mins by stopped-flow CO2 hydration method | ChEMBL. | 25267005 |
Ki (binding) | = 3055 nM | Inhibition of human CA-1 after 15 mins by stopped-flow CO2 hydration method | ChEMBL. | 25267005 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.