Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | hypothetical protein | 0.005 | 0 | 0.5 |
Trichomonas vaginalis | valacyclovir hydrolase, putative | 0.0827 | 0.1955 | 1 |
Trypanosoma cruzi | monoglyceride lipase, putative | 0.0827 | 0.1955 | 1 |
Mycobacterium tuberculosis | Possible lysophospholipase | 0.0876 | 0.208 | 0.208 |
Giardia lamblia | ENC6 protein | 0.005 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable amidase AmiA2 (aminohydrolase) | 0.012 | 0.0177 | 0.0177 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0827 | 0.1955 | 1 |
Mycobacterium leprae | PROBABLE AMIDASE AMIC (AMINOHYDROLASE) | 0.012 | 0.0177 | 0.0849 |
Schistosoma mansoni | neuropathy target esterase/swiss cheese-related protein | 0.0147 | 0.0245 | 0.1033 |
Echinococcus multilocularis | glutamyl tRNA(Gln) amidotransferase subunit A | 0.012 | 0.0177 | 0.0744 |
Mycobacterium tuberculosis | Possible amidase (aminohydrolase) | 0.012 | 0.0177 | 0.0177 |
Mycobacterium ulcerans | amidase | 0.012 | 0.0177 | 0.0177 |
Toxoplasma gondii | hydrolase, alpha/beta fold family protein | 0.005 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved protein | 0.0159 | 0.0276 | 0.0276 |
Loa Loa (eye worm) | amidase | 0.012 | 0.0177 | 0.0744 |
Chlamydia trachomatis | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.012 | 0.0177 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0827 | 0.1955 | 0.1955 |
Brugia malayi | amidase | 0.0993 | 0.2373 | 1 |
Plasmodium falciparum | lysophospholipase, putative | 0.0827 | 0.1955 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0827 | 0.1955 | 1 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0827 | 0.1955 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0827 | 0.1955 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0993 | 0.2373 | 1 |
Mycobacterium ulcerans | amidase | 0.012 | 0.0177 | 0.0177 |
Mycobacterium tuberculosis | Probable amidase AmiD (acylamidase) (acylase) | 0.012 | 0.0177 | 0.0177 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0993 | 0.2373 | 1 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0993 | 0.2373 | 1 |
Mycobacterium ulcerans | amidase | 0.012 | 0.0177 | 0.0177 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0993 | 0.2373 | 1 |
Trypanosoma cruzi | amidase, putative | 0.012 | 0.0177 | 0.0903 |
Onchocerca volvulus | 0.0159 | 0.0276 | 1 | |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0827 | 0.1955 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0993 | 0.2373 | 1 |
Mycobacterium tuberculosis | Probable amidase AmiB2 (aminohydrolase) | 0.012 | 0.0177 | 0.0177 |
Giardia lamblia | Protein phosphatase methylesterase-1 | 0.005 | 0 | 0.5 |
Brugia malayi | Amidase family protein | 0.012 | 0.0177 | 0.0744 |
Trypanosoma brucei | fatty-acid amide hydrolase, putative | 0.012 | 0.0177 | 0.0903 |
Plasmodium falciparum | lysophospholipase, putative | 0.0827 | 0.1955 | 1 |
Schistosoma mansoni | glutamyl-tRNA(Gln) amidotransferase subunit A | 0.012 | 0.0177 | 0.0744 |
Echinococcus multilocularis | patatin phospholipase domain containing protein | 0.0159 | 0.0276 | 0.1162 |
Echinococcus granulosus | patatin phospholipase domain containing protein | 0.0159 | 0.0276 | 0.1162 |
Schistosoma mansoni | amidase | 0.0993 | 0.2373 | 1 |
Loa Loa (eye worm) | amidase | 0.012 | 0.0177 | 0.0744 |
Giardia lamblia | Hypothetical protein | 0.005 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable amidase AmiC (aminohydrolase) | 0.012 | 0.0177 | 0.0177 |
Mycobacterium ulcerans | amidase | 0.012 | 0.0177 | 0.0177 |
Toxoplasma gondii | chain a, pp2a-specific methylesterase apo form (pme), putative | 0.005 | 0 | 0.5 |
Plasmodium falciparum | esterase, putative | 0.0827 | 0.1955 | 1 |
Toxoplasma gondii | hypothetical protein | 0.005 | 0 | 0.5 |
Brugia malayi | Amidase family protein | 0.012 | 0.0177 | 0.0744 |
Brugia malayi | Hypothetical UPF0028 protein ZK370.4 in chromosome III, putative | 0.0159 | 0.0276 | 0.1162 |
Toxoplasma gondii | hypothetical protein | 0.005 | 0 | 0.5 |
Mycobacterium ulcerans | lysophospholipase | 0.0827 | 0.1955 | 0.1955 |
Leishmania major | monoglyceride lipase, putative | 0.0827 | 0.1955 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0827 | 0.1955 | 1 |
Giardia lamblia | Hypothetical protein | 0.005 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.012 | 0.0177 | 0.0903 |
Plasmodium falciparum | lysophospholipase, putative | 0.0827 | 0.1955 | 1 |
Wolbachia endosymbiont of Brugia malayi | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.012 | 0.0177 | 0.5 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.012 | 0.0177 | 0.0744 |
Treponema pallidum | hypothetical protein | 0.0137 | 0.0221 | 1 |
Mycobacterium leprae | PROBABLE GLUTAMYL-TRNA(GLN) AMIDOTRANSFERASE (SUBUNIT A) GATA (Glu-ADT SUBUNIT A) | 0.012 | 0.0177 | 0.0849 |
Echinococcus granulosus | glutamyl tRNAGln amidotransferase subunit A | 0.012 | 0.0177 | 0.0744 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0827 | 0.1955 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0993 | 0.2373 | 1 |
Toxoplasma gondii | hydrolase, alpha/beta fold family protein | 0.005 | 0 | 0.5 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.012 | 0.0177 | 0.0744 |
Treponema pallidum | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.012 | 0.0177 | 0.7983 |
Schistosoma mansoni | neuropathy target esterase/swiss cheese-related protein | 0.0147 | 0.0245 | 0.1033 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0827 | 0.1955 | 1 |
Mycobacterium ulcerans | aspartyl/glutamyl-tRNA amidotransferase subunit A | 0.012 | 0.0177 | 0.0177 |
Trypanosoma brucei | monoglyceride lipase, putative | 0.0827 | 0.1955 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0827 | 0.1955 | 1 |
Giardia lamblia | Hypothetical protein | 0.005 | 0 | 0.5 |
Brugia malayi | putative amidase | 0.012 | 0.0177 | 0.0744 |
Loa Loa (eye worm) | hypothetical protein | 0.0159 | 0.0276 | 0.1162 |
Mycobacterium ulcerans | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD | 0.4024 | 1 | 1 |
Mycobacterium ulcerans | peptide amidase, GatA | 0.012 | 0.0177 | 0.0177 |
Trypanosoma cruzi | amidase, putative | 0.012 | 0.0177 | 0.0903 |
Mycobacterium leprae | POSSIBLE LYSOPHOSPHOLIPASE | 0.0876 | 0.208 | 1 |
Entamoeba histolytica | hydrolase, alpha/beta fold family domain containing protein | 0.0827 | 0.1955 | 0.5 |
Plasmodium vivax | PST-A protein | 0.0827 | 0.1955 | 1 |
Mycobacterium ulcerans | amidase | 0.012 | 0.0177 | 0.0177 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.012 | 0.0177 | 0.0744 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.