Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | carbonic anhydrase II | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase XII | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase IX | Starlite/ChEMBL | References |
Homo sapiens | carbonic anhydrase I | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | carbonic anhydrase XII | 354 aa | 295 aa | 23.1 % |
Trypanosoma brucei | carbonic anhydrase-like protein | carbonic anhydrase I | 261 aa | 281 aa | 25.3 % |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | carbonic anhydrase II | 260 aa | 259 aa | 32.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | LBP / BPI / CETP family, N-terminal domain containing protein | 0.0476 | 1 | 1 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.0367 | 0.5229 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0248 | 0 | 0.5 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.0367 | 0.5229 | 1 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0273 | 0.1099 | 0.1099 |
Onchocerca volvulus | 0.0476 | 1 | 1 | |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0367 | 0.5229 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.1099 | 0.1099 |
Onchocerca volvulus | 0.0476 | 1 | 1 | |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0367 | 0.5229 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.1099 | 0.1099 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.0367 | 0.5229 | 1 |
Onchocerca volvulus | 0.0476 | 1 | 1 | |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0248 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.1099 | 0.1099 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0476 | 1 | 1 |
Onchocerca volvulus | 0.0476 | 1 | 1 | |
Onchocerca volvulus | 0.0476 | 1 | 1 | |
Onchocerca volvulus | 0.0476 | 1 | 1 | |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0367 | 0.5229 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.1099 | 0.1099 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.0367 | 0.5229 | 1 |
Onchocerca volvulus | 0.0476 | 1 | 1 | |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.0367 | 0.5229 | 1 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0273 | 0.1099 | 0.1099 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.0367 | 0.5229 | 1 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0273 | 0.1099 | 0.1099 |
Brugia malayi | P38 map kinase family protein 2 | 0.0367 | 0.5229 | 0.5229 |
Onchocerca volvulus | 0.0476 | 1 | 1 | |
Brugia malayi | hypothetical protein | 0.0273 | 0.1099 | 0.1099 |
Loa Loa (eye worm) | LBP/BPI/CETP family domain-containing protein | 0.0273 | 0.1099 | 0.1099 |
Loa Loa (eye worm) | hypothetical protein | 0.0273 | 0.1099 | 0.1099 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0476 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0273 | 0.1099 | 0.1099 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.0367 | 0.5229 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.0367 | 0.5229 | 0.5229 |
Loa Loa (eye worm) | hypothetical protein | 0.0476 | 1 | 1 |
Brugia malayi | LBP / BPI / CETP family, C-terminal domain containing protein | 0.0273 | 0.1099 | 0.1099 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 9 nM | Inhibition of human recombinant CA9 catalytic domain by stopped flow CO2 hydration assay | ChEMBL. | 25438758 |
Ki (binding) | = 85 nM | Inhibition of human full length CA2 by stopped flow CO2 hydration assay | ChEMBL. | 25438758 |
Ki (binding) | = 415 nM | Inhibition of human recombinant CA12 catalytic domain by stopped flow CO2 hydration assay | ChEMBL. | 25438758 |
Ki (binding) | > 10000 nM | Inhibition of human full length CA1 by stopped flow CO2 hydration assay | ChEMBL. | 25438758 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.