Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | dipeptidyl-peptidase 4 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0209 | 0.4399 | 0.4399 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0209 | 0.4399 | 0.4399 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0209 | 0.4399 | 1 |
Onchocerca volvulus | 0.0451 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0795 | 0.0795 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.007 | 0.118 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.007 | 0.118 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.007 | 0.118 | 1 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.007 | 0.118 | 0.2682 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0019 | 0 | 0.5 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.007 | 0.118 | 0.2682 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.007 | 0.118 | 1 |
Brugia malayi | hypothetical protein | 0.0054 | 0.0795 | 0.0795 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.007 | 0.118 | 1 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0 | 0.5 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.007 | 0.118 | 1 |
Giardia lamblia | DINP protein human, muc B family | 0.0019 | 0 | 0.5 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0019 | 0 | 0.5 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0209 | 0.4399 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.007 | 0.118 | 0.118 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0209 | 0.4399 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0019 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0019 | 0 | 0.5 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0019 | 0 | 0.5 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0451 | 1 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0019 | 0 | 0.5 |
Onchocerca volvulus | 0.0451 | 1 | 1 | |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.007 | 0.118 | 0.2682 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 879 nM | Inhibition of human DPP4 expressed in baculovirus expression system using Gly-Pro-AMC substrate incubated or 30 mins by fluorescence based assay | ChEMBL. | 22503246 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.