Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan AA, family A1, cathepsin D-like aspartic peptidase | 0.0403 | 0.2076 | 0.5 |
Plasmodium vivax | plasmepsin IV, putative | 0.0403 | 0.2076 | 1 |
Loa Loa (eye worm) | aspartic protease BmAsp-2 | 0.0403 | 0.2076 | 1 |
Plasmodium falciparum | plasmepsin VI | 0.0403 | 0.2076 | 1 |
Brugia malayi | Kinesin motor domain containing protein | 0.0137 | 0 | 0.5 |
Toxoplasma gondii | aspartyl proteinase (eimepsin), putative | 0.0403 | 0.2076 | 1 |
Plasmodium vivax | aspartyl proteinase, putative | 0.0403 | 0.2076 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0915 | 0.6069 | 0.6069 |
Schistosoma mansoni | tyrosine kinase | 0.0776 | 0.4985 | 0.4985 |
Plasmodium falciparum | plasmepsin II | 0.0403 | 0.2076 | 1 |
Echinococcus multilocularis | kinesin family 1 | 0.1052 | 0.7134 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0758 | 0.4846 | 0.4846 |
Schistosoma mansoni | cathepsin D (A01 family) | 0.1419 | 1 | 1 |
Schistosoma mansoni | subfamily A1A unassigned peptidase (A01 family) | 0.0403 | 0.2076 | 0.2076 |
Plasmodium vivax | aspartyl protease, putative | 0.0383 | 0.1921 | 0.9257 |
Giardia lamblia | Kinesin-5 | 0.0137 | 0 | 0.5 |
Plasmodium falciparum | plasmepsin IX | 0.0383 | 0.1921 | 0.9257 |
Plasmodium vivax | aspartyl protease, putative | 0.0383 | 0.1921 | 0.9257 |
Echinococcus granulosus | kinesin family 1 | 0.1052 | 0.7134 | 1 |
Echinococcus granulosus | tyrosine protein kinase shark | 0.0776 | 0.4985 | 0.5751 |
Plasmodium falciparum | plasmepsin X | 0.0383 | 0.1921 | 0.9257 |
Echinococcus multilocularis | tyrosine protein kinase shark | 0.0776 | 0.4985 | 0.5751 |
Toxoplasma gondii | aspartyl protease ASP1 | 0.0403 | 0.2076 | 1 |
Plasmodium falciparum | plasmepsin I | 0.0403 | 0.2076 | 1 |
Entamoeba histolytica | kinesin, putative | 0.0137 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0403 | 0.2076 | 1 |
Plasmodium falciparum | plasmepsin IV | 0.0403 | 0.2076 | 1 |
Toxoplasma gondii | aspartyl protease ASP3 | 0.0383 | 0.1921 | 0.9257 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.