Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0306 | 0.2852 | 0.2791 |
Echinococcus multilocularis | serotonin receptor | 0.0099 | 0.0404 | 0.0321 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0072 | 0.0085 | 0.5 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.0072 | 0.0085 | 0.5 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0306 | 0.2852 | 0.2791 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.091 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0404 | 0.0404 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.0072 | 0.0085 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0234 | 0.1999 | 0.1999 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0114 | 0.058 | 0.0499 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0085 | 0.0085 |
Echinococcus multilocularis | raf serine:threonine protein kinase | 0.0114 | 0.058 | 0.0499 |
Plasmodium falciparum | peptidase, putative | 0.0072 | 0.0085 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0085 | 0.0085 |
Echinococcus granulosus | macrophage colony stimulating factor 1 receptor | 0.029 | 0.266 | 0.2597 |
Loa Loa (eye worm) | hypothetical protein | 0.0072 | 0.0085 | 0.0085 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0306 | 0.2852 | 1 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0072 | 0.0085 | 0.5 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0072 | 0.0085 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0072 | 0.0085 | 0.5 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0072 | 0.0085 | 0.5 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.091 | 1 | 1 |
Brugia malayi | Raf kinase | 0.011 | 0.0533 | 0.0452 |
Echinococcus multilocularis | serotonin receptor | 0.0099 | 0.0404 | 0.0321 |
Loa Loa (eye worm) | hypothetical protein | 0.0099 | 0.0404 | 0.0404 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0306 | 0.2852 | 1 |
Echinococcus granulosus | raf serine:threonine protein kinase | 0.0114 | 0.058 | 0.0499 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.091 | 1 | 1 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0306 | 0.2852 | 1 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.091 | 1 | 1 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0072 | 0.0085 | 0.5 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0072 | 0.0085 | 0.5 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0072 | 0.0085 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0072 | 0.0085 | 0.5 |
Mycobacterium tuberculosis | Probable peptidase | 0.0072 | 0.0085 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0099 | 0.0404 | 0.0321 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0306 | 0.2852 | 1 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0072 | 0.0085 | 0.5 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0306 | 0.2852 | 1 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0099 | 0.0404 | 0.0321 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0072 | 0.0085 | 0.5 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0306 | 0.2852 | 0.2791 |
Brugia malayi | hypothetical protein | 0.0234 | 0.1999 | 0.193 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0072 | 0.0085 | 0.5 |
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0306 | 0.2852 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.091 | 1 | 1 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0306 | 0.2852 | 0.2791 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0072 | 0.0085 | 0.5 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0072 | 0.0085 | 0.0085 |
Loa Loa (eye worm) | raf kinase | 0.0113 | 0.0565 | 0.0565 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 46 % | Percent inhibition of the charcoal meal transfer in mice(100 mg/kg). | ChEMBL. | 7143364 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.