Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0233 | 0.6278 | 0.8674 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0233 | 0.6278 | 0.6278 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.025 | 0.7238 | 0.7238 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0233 | 0.6278 | 0.6278 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0233 | 0.6278 | 0.8674 |
Echinococcus granulosus | FTZ F1 alpha | 0.0233 | 0.6278 | 0.8674 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0233 | 0.6278 | 0.6278 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0233 | 0.6278 | 0.6278 |
Schistosoma mansoni | nuclear hormone receptor | 0.0233 | 0.6278 | 0.6278 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0233 | 0.6278 | 0.8674 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0233 | 0.6278 | 0.6278 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0233 | 0.6278 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.6278 | 0.6278 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0228 | 0.6023 | 0.6023 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0233 | 0.6278 | 0.8674 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0233 | 0.6278 | 0.6278 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0233 | 0.6278 | 0.6278 |
Echinococcus granulosus | beta-adrenergic receptor kinase | 0.0228 | 0.6023 | 0.8321 |
Echinococcus multilocularis | beta adrenergic receptor kinase | 0.0228 | 0.6023 | 0.8321 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0233 | 0.6278 | 0.6278 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0233 | 0.6278 | 0.6278 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.6278 | 0.6278 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0233 | 0.6278 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0228 | 0.6023 | 0.6023 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0233 | 0.6278 | 0.8674 |
Brugia malayi | Probable G protein-coupled receptor kinase F19C6.1, putative | 0.025 | 0.7238 | 0.7238 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0233 | 0.6278 | 0.8674 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0233 | 0.6278 | 0.6278 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0233 | 0.6278 | 0.8674 |
Brugia malayi | ecdysteroid receptor | 0.0233 | 0.6278 | 0.6278 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0233 | 0.6278 | 0.8674 |
Loa Loa (eye worm) | AGC/GRK/BARK protein kinase | 0.0228 | 0.6023 | 0.6023 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0233 | 0.6278 | 0.8674 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.6278 | 0.6278 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0233 | 0.6278 | 0.6278 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0233 | 0.6278 | 0.6278 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0233 | 0.6278 | 0.6278 |
Brugia malayi | nuclear receptor NHR-88 | 0.0233 | 0.6278 | 0.6278 |
Loa Loa (eye worm) | G protein-coupled receptor kinase 1 | 0.025 | 0.7238 | 0.7238 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0233 | 0.6278 | 0.6278 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0233 | 0.6278 | 0.6278 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0233 | 0.6278 | 0.8674 |
Loa Loa (eye worm) | AGC/GRK/GRK protein kinase | 0.0298 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0233 | 0.6278 | 0.6278 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0233 | 0.6278 | 0.8674 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0233 | 0.6278 | 0.6278 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0233 | 0.6278 | 0.6278 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0233 | 0.6278 | 0.6278 |
Echinococcus granulosus | [G-protein-coupledreceptor] kinase | 0.025 | 0.7238 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0233 | 0.6278 | 0.6278 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0233 | 0.6278 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0233 | 0.6278 | 0.8674 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.6278 | 0.6278 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0233 | 0.6278 | 0.6278 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0233 | 0.6278 | 0.6278 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.6278 | 0.6278 |
Echinococcus granulosus | G protein coupled receptor kinase 1 | 0.018 | 0.3261 | 0.4506 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0298 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0233 | 0.6278 | 0.8674 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0233 | 0.6278 | 0.6278 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.6278 | 0.6278 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0233 | 0.6278 | 0.6278 |
Schistosoma mansoni | thyroid hormone receptor | 0.0233 | 0.6278 | 0.6278 |
Schistosoma mansoni | thyroid hormone receptor | 0.0233 | 0.6278 | 0.6278 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.6278 | 0.6278 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0233 | 0.6278 | 0.8674 |
Loa Loa (eye worm) | hypothetical protein | 0.0233 | 0.6278 | 0.6278 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0233 | 0.6278 | 0.6278 |
Brugia malayi | steroid hormone receptor | 0.0233 | 0.6278 | 0.6278 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0233 | 0.6278 | 0.6278 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0233 | 0.6278 | 0.6278 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0233 | 0.6278 | 0.8674 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0233 | 0.6278 | 0.6278 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0233 | 0.6278 | 0.8674 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0233 | 0.6278 | 0.6278 |
Echinococcus multilocularis | G protein coupled receptor kinase 6 | 0.025 | 0.7238 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0233 | 0.6278 | 0.6278 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0233 | 0.6278 | 0.6278 |
Onchocerca volvulus | 0.0233 | 0.6278 | 0.5 | |
Schistosoma mansoni | coup transcription factor | 0.0233 | 0.6278 | 0.6278 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0233 | 0.6278 | 0.6278 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0233 | 0.6278 | 0.6278 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0233 | 0.6278 | 0.8674 |
Echinococcus multilocularis | G protein coupled receptor kinase 1 | 0.018 | 0.3261 | 0.4506 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0233 | 0.6278 | 0.6278 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.