Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0186 | 0.5866 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0311 | 0.053 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0086 | 0.1905 | 0.4618 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0041 | 0.0145 | 0.0247 |
Echinococcus granulosus | neutral alpha glucosidase AB | 0.0041 | 0.0145 | 0.0214 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0311 | 0.0498 |
Schistosoma mansoni | ngng-dimethylarginine dimethylaminohydrolase | 0.0185 | 0.5806 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0291 | 1 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0086 | 0.1905 | 0.4618 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0052 | 0.0569 | 0.0971 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0039 | 0.0051 | 0.0087 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0291 | 1 | 1 |
Mycobacterium leprae | Probable fructose bisphosphate aldolase Fba | 0.0142 | 0.4125 | 1 |
Plasmodium vivax | glutathione reductase, putative | 0.0038 | 0 | 0.5 |
Echinococcus granulosus | ng dimethylarginine dimethylaminohydrolase | 0.0185 | 0.5806 | 0.9897 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0045 | 0.0311 | 0.0498 |
Schistosoma mansoni | lipoxygenase | 0.0117 | 0.3149 | 0.5382 |
Entamoeba histolytica | fructose-1,6-bisphosphate aldolase, putative | 0.0291 | 1 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0291 | 1 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0311 | 0.053 |
Schistosoma mansoni | alpha glucosidase | 0.0041 | 0.0145 | 0.0163 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0086 | 0.1905 | 0.4618 |
Schistosoma mansoni | alpha-glucosidase | 0.016 | 0.4842 | 0.8325 |
Leishmania major | hypothetical protein, unknown function | 0.0185 | 0.5806 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0145 | 1 |
Giardia lamblia | Fructose-bisphosphate aldolase | 0.0291 | 1 | 0.5 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0186 | 0.5866 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0057 | 0.0763 | 0.1301 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0186 | 0.5866 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0185 | 0.5806 | 0.9898 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0311 | 0.0498 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0057 | 0.0763 | 0.1301 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0086 | 0.1905 | 0.4618 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0095 | 0.2283 | 0.5535 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0095 | 0.2283 | 0.5535 |
Mycobacterium tuberculosis | Probable fructose-bisphosphate aldolase Fba | 0.0142 | 0.4125 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0038 | 0 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0052 | 0.0569 | 0.0971 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0311 | 0.0451 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0186 | 0.5866 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0038 | 0 | 0.5 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0041 | 0.0145 | 0.0247 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0311 | 0.0451 |
Echinococcus multilocularis | neutral alpha glucosidase AB | 0.0041 | 0.0145 | 0.0214 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0186 | 0.5866 | 1 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0095 | 0.2283 | 0.1705 |
Mycobacterium tuberculosis | Probable reductase | 0.0086 | 0.1905 | 0.4618 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0041 | 0.0145 | 1 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0291 | 1 | 1 |
Onchocerca volvulus | 0.0185 | 0.5806 | 1 | |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0291 | 1 | 1 |
Mycobacterium ulcerans | fructose-bisphosphate aldolase | 0.0142 | 0.4125 | 0.5 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0117 | 0.3149 | 0.5352 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0291 | 1 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0082 | 0.1754 | 0.2958 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0041 | 0.0145 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0311 | 0.0451 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0095 | 0.2283 | 0.5535 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0763 | 0.1301 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0086 | 0.1905 | 0.4618 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0291 | 1 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0038 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0045 | 0.0311 | 0.0498 |
Brugia malayi | NG,NG-dimethylarginine dimethylaminohydrolase 1, putative | 0.0185 | 0.5806 | 0.9898 |
Treponema pallidum | fructose-bisphosphate aldolase | 0.0291 | 1 | 0.5 |
Trichomonas vaginalis | fructose-bisphosphate aldolase, putative | 0.0291 | 1 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0117 | 0.3149 | 0.5352 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0057 | 0.0763 | 0.1301 |
Leishmania major | hypothetical protein, unknown function | 0.0185 | 0.5806 | 1 |
Schistosoma mansoni | ngng-dimethylarginine dimethylaminohydrolase | 0.0185 | 0.5806 | 1 |
Trypanosoma brucei | glucosidase, putative | 0.0041 | 0.0145 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.016 | 0.4842 | 0.8325 |
Echinococcus multilocularis | ng dimethylarginine dimethylaminohydrolase | 0.0185 | 0.5806 | 0.9897 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.0051 | 0.0087 |
Leishmania major | alpha glucosidase II subunit, putative | 0.0041 | 0.0145 | 0.0249 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI50 (functional) | -6.887 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.769 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.644 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -6.545 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.87 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.832 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.814 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.808 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.791 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.768 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.733 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.732 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MDA-N Breast cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.716 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.678 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.643 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.612 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.612 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.526 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the NCI-H23 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -5.243 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
GI50 (functional) | -4.923 | PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the DU-145 Prostate cell line. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.