Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | serum/glucocorticoid regulated kinase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | galactoside-binding lectin family protein | 0.0902 | 1 | 1 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.0033 | 0.0004 | 0.5 |
Brugia malayi | galectin | 0.0902 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.005 | 0.0198 | 0.5 |
Toxoplasma gondii | AGC kinase | 0.005 | 0.0198 | 0.5 |
Onchocerca volvulus | Galectin homolog | 0.0902 | 1 | 0.5 |
Trypanosoma cruzi | Protein kinase B | 0.0033 | 0.0004 | 0.5 |
Onchocerca volvulus | Galectin homolog | 0.0902 | 1 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.005 | 0.0198 | 0.5 |
Echinococcus multilocularis | Galectin, carbohydrate recognition domain | 0.0902 | 1 | 1 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0033 | 0.0004 | 0.5 |
Brugia malayi | Galactoside-binding lectin family protein | 0.0902 | 1 | 1 |
Brugia malayi | Galactoside-binding lectin family protein | 0.0902 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.005 | 0.0198 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0902 | 1 | 1 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0033 | 0.0004 | 0.0004 |
Loa Loa (eye worm) | hypothetical protein | 0.0902 | 1 | 1 |
Loa Loa (eye worm) | galactoside-binding lectin family protein | 0.0902 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0902 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.005 | 0.0198 | 0.5 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0033 | 0.0004 | 0.0004 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.005 | 0.0198 | 0.5 |
Loa Loa (eye worm) | galactoside-binding lectin family protein | 0.0902 | 1 | 1 |
Giardia lamblia | Kinase, AGC PKA | 0.0033 | 0.0004 | 0.5 |
Loa Loa (eye worm) | galectin | 0.0902 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.005 | 0.0198 | 0.5 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0033 | 0.0004 | 0.0004 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.0033 | 0.0004 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.005 | 0.0198 | 1 |
Schistosoma mansoni | galectin | 0.0902 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.005 | 0.0198 | 0.5 |
Entamoeba histolytica | protein kinase, putative | 0.005 | 0.0198 | 1 |
Brugia malayi | galectin | 0.0902 | 1 | 1 |
Loa Loa (eye worm) | galectin | 0.0902 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.005 | 0.0198 | 0.5 |
Trichomonas vaginalis | AGC family protein kinase | 0.005 | 0.0198 | 0.5 |
Brugia malayi | Galactoside-binding lectin family protein | 0.0902 | 1 | 1 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0033 | 0.0004 | 0.5 |
Echinococcus granulosus | Galectin carbohydrate recognition domain | 0.0902 | 1 | 1 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0033 | 0.0004 | 0.0004 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0033 | 0.0004 | 0.0004 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.016 uM | Inhibition of human SGK1 using fluo-5(6)-carboxyfluorescein)-RPRAATF-NH2 fluorescently labeled peptide by substrate phosphorylation assay in presence of 10 uM ATP | ChEMBL. | 25589934 |
IC50 (binding) | = 0.76 uM | Inhibition of human SGK1 using fluo-5(6)-carboxyfluorescein)-RPRAATF-NH2 fluorescently labeled peptide by substrate phosphorylation assay in presence of 500 uM ATP | ChEMBL. | 25589934 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.