Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | N-myristoyltransferase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | N-myristoyl transferase, putative | 0.0215982 | 1 | 0.5 |
Echinococcus multilocularis | glycylpeptide N tetradecanoyltransferase | 0.0215982 | 1 | 0.5 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0215982 | 1 | 0.5 |
Plasmodium vivax | glycylpeptide N-tetradecanoyltransferase, putative | 0.0215982 | 1 | 0.5 |
Plasmodium falciparum | glycylpeptide N-tetradecanoyltransferase | 0.0215982 | 1 | 0.5 |
Leishmania major | N-myristoyl transferase, putative | 0.0215982 | 1 | 0.5 |
Brugia malayi | N-myristoyltransferase 2 | 0.0215982 | 1 | 0.5 |
Trypanosoma brucei | N-myristoyltransferase | 0.0215982 | 1 | 0.5 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0215982 | 1 | 0.5 |
Loa Loa (eye worm) | N-myristoyltransferase 2 | 0.0215982 | 1 | 0.5 |
Giardia lamblia | CDC72 | 0.0215982 | 1 | 0.5 |
Schistosoma mansoni | N-myristoyltransferase | 0.0215982 | 1 | 0.5 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0215982 | 1 | 1 |
Entamoeba histolytica | glycylpeptide N-tetradecanoyltransferase, putative | 0.0215982 | 1 | 0.5 |
Echinococcus granulosus | glycylpeptide N tetradecanoyltransferase | 0.0215982 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
AUC (ADMET) | = 3400 microg/min/ml | AUC (0 to 8 hrs) in NMRI mouse at 10 mg/kg, po by UPLC-MS/MS method | ChEMBL. | 25412409 |
EC50 (functional) | = 0.0004 uM | Antitrypanosomal activity against Trypanosoma brucei BSF427 expressing VSG118 infected in human MRC5 cells assessed as reduction cell viability incubated for 69 hrs by rezasurin dye based assay | ChEMBL. | 25412409 |
EC50 (ADMET) | = 0.09 uM | Antiproliferative activity against human MRC5 cells assessed as reduction cell viability incubated for 69 hrs by rezasurin dye based assay | ChEMBL. | 25412409 |
FC (functional) | = 2 | Trypanocidal activity against bloodstream form of Trypanosoma brucei rhodesiense STIB900 infected in mouse assessed as increase in HAT therapeutic window at 20 mg/kg, po bid | ChEMBL. | 25412409 |
IC50 (binding) | = 0.004 uM | Inhibition of human N-myristoyltransferase 1 assessed as transfer of [3H]-myristic acid to a biotinylated substrate peptide (GCGGSKVKPQPPQAK(biotin)-amide by scintillation proximity assay | ChEMBL. | 25412409 |
MCD (functional) | = 6 mg kg-1 | Trypanocidal activity against bloodstream form of Trypanosoma brucei rhodesiense STIB900 infected in twice daily po dosed mouse | ChEMBL. | 25412409 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma brucei | ChEMBL23 | 25412409 | |
Homo sapiens | ChEMBL23 | 25412409 | |
Trypanosoma brucei gambiense | 25412409 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.