Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Rhodanese-like domain containing protein | 0.0131073 | 0.808733 | 0.739333 |
Brugia malayi | Protein prenyltransferase alpha subunit repeat containing protein | 0.0145749 | 1 | 1 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0131073 | 0.808733 | 0.739333 |
Brugia malayi | Rhodanese-like domain containing protein | 0.0131073 | 0.808733 | 0.739333 |
Onchocerca volvulus | 0.0131073 | 0.808733 | 0.5 | |
Echinococcus multilocularis | protein farnesyltransferase alpha subunit | 0.0145749 | 1 | 1 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0131073 | 0.808733 | 0.739333 |
Trichomonas vaginalis | m-phase inducer phosphatase, putative | 0.0131073 | 0.808733 | 0.739333 |
Loa Loa (eye worm) | hypothetical protein | 0.0131073 | 0.808733 | 0.739333 |
Leishmania major | farnesyltransferase beta subunit | 0.00894459 | 0.26624 | 0.5 |
Plasmodium vivax | prenyltransferase alpha subunit, putative | 0.0145749 | 1 | 1 |
Schistosoma mansoni | m-phase inducer phosphatase(cdc25) | 0.0131073 | 0.808733 | 0.739333 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.0131073 | 0.808733 | 0.739333 |
Onchocerca volvulus | 0.0131073 | 0.808733 | 0.5 | |
Plasmodium vivax | farnesyltransferase beta subunit, putative | 0.00894459 | 0.26624 | 0.26624 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0131073 | 0.808733 | 0.739333 |
Plasmodium falciparum | protein farnesyltransferase subunit alpha | 0.0145749 | 1 | 1 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0118467 | 0.644452 | 0.515443 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0131073 | 0.808733 | 0.739333 |
Trichomonas vaginalis | cdc25c, putative | 0.0131073 | 0.808733 | 0.739333 |
Loa Loa (eye worm) | hypothetical protein | 0.0131073 | 0.808733 | 0.739333 |
Toxoplasma gondii | hypothetical protein | 0.0118467 | 0.644452 | 1 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0145749 | 1 | 1 |
Trypanosoma cruzi | protein farnesyltransferase, putative | 0.00894459 | 0.26624 | 0.5 |
Echinococcus multilocularis | m phase inducer phosphatase(cdc25) | 0.0131073 | 0.808733 | 0.739333 |
Trichomonas vaginalis | cdc25b, putative | 0.0131073 | 0.808733 | 0.739333 |
Trypanosoma brucei | protein farnesyltransferase beta subunit | 0.00894459 | 0.26624 | 0.5 |
Trichomonas vaginalis | m-phase inducer phosphatase, putative | 0.0131073 | 0.808733 | 0.739333 |
Loa Loa (eye worm) | hypothetical protein | 0.012012 | 0.665992 | 0.5448 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative | 0.0145749 | 1 | 1 |
Onchocerca volvulus | 0.0131073 | 0.808733 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0145749 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.012012 | 0.665992 | 0.5448 |
Trichomonas vaginalis | cdc25b, putative | 0.0131073 | 0.808733 | 0.739333 |
Schistosoma mansoni | protein farnesyltransferase alpha subunit | 0.0145749 | 1 | 1 |
Onchocerca volvulus | 0.0131073 | 0.808733 | 0.5 | |
Loa Loa (eye worm) | prenyltransferase alpha subunit repeat containing protein | 0.0145749 | 1 | 1 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.0131073 | 0.808733 | 0.739333 |
Echinococcus granulosus | m phase inducer phosphatasecdc25 | 0.0131073 | 0.808733 | 0.739333 |
Trypanosoma cruzi | protein farnesyltransferase, putative | 0.00894459 | 0.26624 | 0.5 |
Trichomonas vaginalis | protein farnesyltransferase alpha subunit, putative | 0.0145749 | 1 | 1 |
Echinococcus granulosus | protein farnesyltransferase alpha subunit | 0.0145749 | 1 | 1 |
Giardia lamblia | Rab geranylgeranyltransferase | 0.0145749 | 1 | 1 |
Entamoeba histolytica | protein farnesyltransferase alpha subunit, putative | 0.0145749 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.046 uM | Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as inhibition of parasite growth after 72 hrs by parasite LDH release assay | ChEMBL. | 25462261 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 25462261 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.