Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | G protein-coupled receptor 119 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | follicle stimulating hormone receptor | G protein-coupled receptor 119 | 335 aa | 274 aa | 22.3 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0545 | 0 | 0.5 | |
Brugia malayi | Carboxylesterase family protein | 0.3228 | 1 | 1 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0745 | 0.0744 | 0.0744 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.3228 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0745 | 0.0744 | 0.0744 |
Brugia malayi | amidase | 0.0745 | 0.0744 | 0.0744 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0545 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.3228 | 1 | 1 |
Onchocerca volvulus | 0.0545 | 0 | 0.5 | |
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.0545 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.3228 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.3228 | 1 | 1 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.0545 | 0 | 0.5 |
Onchocerca volvulus | 0.0545 | 0 | 0.5 | |
Schistosoma mansoni | amidase | 0.0745 | 0.0744 | 0.0744 |
Echinococcus multilocularis | carboxylesterase 5A | 0.3228 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.3228 | 1 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.3228 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.3228 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.3228 | 1 | 1 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0745 | 0.0744 | 0.0744 |
Echinococcus multilocularis | acetylcholinesterase | 0.3228 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.0545 | 0 | 0.5 |
Onchocerca volvulus | 0.0545 | 0 | 0.5 | |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.0545 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.3228 | 1 | 1 |
Onchocerca volvulus | 0.0545 | 0 | 0.5 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.0545 | 0 | 0.5 |
Echinococcus granulosus | fatty acid amide hydrolase 1 | 0.0745 | 0.0744 | 0.0744 |
Echinococcus multilocularis | fatty acid amide hydrolase 1 | 0.0745 | 0.0744 | 0.0744 |
Schistosoma mansoni | fatty-acid amide hydrolase | 0.0745 | 0.0744 | 0.0744 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 298 nM | Agonist activity at human GPR119 overexpressed in CHO cells assessed as increase in cellular cAMP production by HTRF method | ChEMBL. | 25455488 |
Efficacy (binding) | = 81 % | Agonist activity at human GPR119 overexpressed in CHO cells assessed as increase in cellular cAMP production by HTRF method relative to AR231453 | ChEMBL. | 25455488 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.