Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase kinase kinase 12 | Starlite/ChEMBL | No references |
Homo sapiens | delta-like 1 homolog (Drosophila) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Calcium binding EGF domain containing protein | delta-like 1 homolog (Drosophila) | 383 aa | 319 aa | 25.7 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.054 | 1 | 1 |
Onchocerca volvulus | 0.0015 | 0 | 0.5 | |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.054 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.054 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.054 | 1 | 1 |
Echinococcus granulosus | mitogen activated protein kinase kinase kinase | 0.0159 | 0.2748 | 0.2748 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.271 | 0.271 |
Onchocerca volvulus | Putative cubilin | 0.0015 | 0 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase kinase kinase | 0.0159 | 0.2748 | 0.2748 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.054 | 1 | 0.5 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.054 | 1 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.0159 | 0.2748 | 0.2748 |
Giardia lamblia | High cysteine protein | 0.0015 | 0 | 0.5 |
Onchocerca volvulus | Neurogenic locus notch protein homolog | 0.0015 | 0 | 0.5 |
Loa Loa (eye worm) | TKL/MLK/LZK protein kinase | 0.0159 | 0.2748 | 0.2748 |
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.054 | 1 | 0.5 |
Onchocerca volvulus | 0.0015 | 0 | 0.5 | |
Onchocerca volvulus | 0.0015 | 0 | 0.5 | |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.054 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 0.271 | 0.271 |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.054 | 1 | 1 |
Onchocerca volvulus | Neurogenic locus notch homolog | 0.0015 | 0 | 0.5 |
Onchocerca volvulus | 0.0015 | 0 | 0.5 | |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.054 | 1 | 1 |
Toxoplasma gondii | EGF family domain-containing protein | 0.0015 | 0 | 0.5 |
Onchocerca volvulus | Slit protein homolog | 0.0015 | 0 | 0.5 |
Onchocerca volvulus | 0.0015 | 0 | 0.5 | |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.054 | 1 | 0.5 |
Schistosoma mansoni | serine/threonine protein kinase | 0.016 | 0.2759 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.00017 uM | Inhibition of DLK (unknown origin) by RT-FRET assay | ChEMBL. | 25589918 |
Ki (binding) | = 0.00017 uM | Inhibition of N-terminally GST-tagged human DLK catalytic domain (1 to 520 amino acids) using N-terminal His-tagged MKK4 K131M substrate incubated for 60 mins by TR-FRET assay | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.