Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase 10 | Starlite/ChEMBL | References |
Homo sapiens | mitogen-activated protein kinase 8 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma japonicum | ko:K04440 c-Jun N-terminal kinase, putative | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Schistosoma mansoni | serine/threonine protein kinase | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Loa Loa (eye worm) | CMGC/MAPK/JNK protein kinase | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Schistosoma japonicum | IPR000164,Histone H3;IPR009072,Histone-fold,domain-containing | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Echinococcus granulosus | c-Jun N-terminal kinases | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Echinococcus multilocularis | c Jun NH2 terminal kinase | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Brugia malayi | Stress-activated protein kinase jnk-1 | Get druggable targets OG5_129677 | All targets in OG5_129677 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | solute carrier family 12 | 0.0809 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0809 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0694 | 0.5442 | 0.5442 |
Loa Loa (eye worm) | hypothetical protein | 0.0809 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0809 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0809 | 1 | 1 |
Schistosoma mansoni | solute carrier family 12 electroneutral k-cl cotransporter | 0.0809 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0694 | 0.5442 | 0.5442 |
Loa Loa (eye worm) | hypothetical protein | 0.0694 | 0.5442 | 0.5442 |
Brugia malayi | Amino acid permease family protein | 0.0809 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0694 | 0.5442 | 0.5442 |
Loa Loa (eye worm) | hypothetical protein | 0.0694 | 0.5442 | 0.5442 |
Loa Loa (eye worm) | hypothetical protein | 0.0809 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0809 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0694 | 0.5442 | 0.5442 |
Loa Loa (eye worm) | hypothetical protein | 0.0694 | 0.5442 | 0.5442 |
Loa Loa (eye worm) | amino acid permease | 0.0809 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0809 | 1 | 1 |
Echinococcus multilocularis | solute carrier family 12 | 0.0809 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 313 nM | Inhibition of JNK3alpha1 (unknown origin) after 1 hr by homogeneous time-resolved fluorescence assay | ChEMBL. | 25393557 |
IC50 (binding) | = 1607 nM | Inhibition of JNK1 (unknown origin) after 1 hr by homogeneous time-resolved fluorescence assay | ChEMBL. | 25393557 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.