Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | N-myristoyltransferase 1 | Starlite/ChEMBL | References |
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSCA1100) (Aspergillus fumigatus) | Glycylpeptide N-tetradecanoyltransferase | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | glycylpeptide N-tetradecanoyltransferase, putative | 0.0215982 | 0.358078 | 0.5 |
Echinococcus multilocularis | cGMP dependent protein kinase 1 | 0.000675322 | 0.00192461 | 0.000487457 |
Echinococcus granulosus | glycylpeptide N tetradecanoyltransferase | 0.0215982 | 0.358078 | 0.357153 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.00288196 | 0.0394863 | 0.0381032 |
Schistosoma mansoni | serine/threonine protein kinase | 0.000675322 | 0.00192461 | 0.000487457 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.00288196 | 0.0394863 | 0.0381032 |
Brugia malayi | Voltage-gated potassium channel, EAG (KCNH1)-related. C. elegans egl-2 ortholog | 0.000942179 | 0.00646709 | 0.00503648 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0215982 | 0.358078 | 0.5 |
Echinococcus granulosus | cGMP dependent protein kinase 1 | 0.000675322 | 0.00192461 | 0.000487457 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.000942179 | 0.00646709 | 0.00503648 |
Echinococcus multilocularis | glycylpeptide N tetradecanoyltransferase | 0.0215982 | 0.358078 | 0.357153 |
Loa Loa (eye worm) | hypothetical protein | 0.00247344 | 0.0325324 | 0.0311394 |
Toxoplasma gondii | protein kinase G AGC kinase family member PKG | 0.000675322 | 0.00192461 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.00317741 | 0.0445155 | 0.0431397 |
Trypanosoma brucei | N-myristoyl transferase, putative | 0.0215982 | 0.358078 | 1 |
Onchocerca volvulus | Serine\/threonine protein kinase homolog | 0.0593092 | 1 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel | 0.00317741 | 0.0445155 | 0.0431397 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.00264375 | 0.0354315 | 0.0953164 |
Schistosoma mansoni | N-myristoyltransferase | 0.0215982 | 0.358078 | 0.357153 |
Brugia malayi | Egg laying defective protein 4 | 0.000675322 | 0.00192461 | 0.000487457 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.000942179 | 0.00646709 | 0.00503648 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.00288196 | 0.0394863 | 0.0381032 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0215982 | 0.358078 | 1 |
Loa Loa (eye worm) | N-myristoyltransferase 2 | 0.0215982 | 0.358078 | 0.357153 |
Brugia malayi | N-myristoyltransferase 2 | 0.0215982 | 0.358078 | 0.357153 |
Echinococcus granulosus | cGMP dependent protein kinase | 0.000675322 | 0.00192461 | 0.000487457 |
Giardia lamblia | CDC72 | 0.0215982 | 0.358078 | 0.5 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0593092 | 1 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0593092 | 1 | 1 |
Echinococcus granulosus | proto oncogene serine:threonine protein kinase | 0.0593092 | 1 | 1 |
Brugia malayi | Serine/threonine-protein kinase Pim-3 | 0.0593092 | 1 | 1 |
Trypanosoma brucei | N-myristoyltransferase | 0.0215982 | 0.358078 | 1 |
Leishmania major | N-myristoyl transferase, putative | 0.0215982 | 0.358078 | 1 |
Echinococcus multilocularis | cGMP dependent protein kinase 1 | 0.000675322 | 0.00192461 | 0.000487457 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.00288196 | 0.0394863 | 0.0381032 |
Echinococcus multilocularis | expressed conserved protein | 0.000675322 | 0.00192461 | 0.000487457 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0141908 | 0.231988 | 0.64645 |
Echinococcus multilocularis | voltage gated potassium channel | 0.000942179 | 0.00646709 | 0.00503648 |
Schistosoma mansoni | serine/threonine protein kinase | 0.000675322 | 0.00192461 | 0.000487457 |
Echinococcus multilocularis | proto oncogene serine:threonine protein kinase | 0.0593092 | 1 | 1 |
Echinococcus granulosus | voltage gated potassium channel | 0.000942179 | 0.00646709 | 0.00503648 |
Brugia malayi | Protein kinase domain containing protein | 0.0593092 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.000942179 | 0.00646709 | 0.00503648 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.00264375 | 0.0354315 | 0.0953164 |
Loa Loa (eye worm) | hypothetical protein | 0.000942179 | 0.00646709 | 0.00503648 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0215982 | 0.358078 | 0.5 |
Loa Loa (eye worm) | AGC/PKG protein kinase | 0.000675322 | 0.00192461 | 0.000487457 |
Plasmodium falciparum | glycylpeptide N-tetradecanoyltransferase | 0.0215982 | 0.358078 | 1 |
Entamoeba histolytica | glycylpeptide N-tetradecanoyltransferase, putative | 0.0215982 | 0.358078 | 0.5 |
Echinococcus granulosus | cGMP dependent protein kinase 1 | 0.000675322 | 0.00192461 | 0.000487457 |
Loa Loa (eye worm) | CAMK/PIM protein kinase | 0.0593092 | 1 | 1 |
Schistosoma mansoni | voltage-gated potassium channel | 0.000942179 | 0.00646709 | 0.00503648 |
Schistosoma mansoni | serine/threonine protein kinase | 0.000675322 | 0.00192461 | 0.000487457 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CL (ADMET) | = 9.7 ml/min/g | Intrinsic clearance in CD1 mouse liver microsomes at 0.5 uM in presence of NADPH incubated for 3 to 30 mins by UPLC-MS/MS method | ChEMBL. | 25412409 |
EC50 (functional) | = 0.87 uM | Antitrypanosomal activity against Trypanosoma brucei BSF427 expressing VSG118 infected in human MRC5 cells assessed as reduction cell viability incubated for 69 hrs by rezasurin dye based assay | ChEMBL. | 25412409 |
EC50 (ADMET) | = 0.9 uM | Antiproliferative activity against human MRC5 cells assessed as reduction cell viability incubated for 69 hrs by rezasurin dye based assay | ChEMBL. | 25412409 |
IC50 (binding) | = 17 nM | Enzyme Inhibition Assay | BINDINGDB. | No reference |
IC50 (binding) | = 35 nM | Enzyme Inhibition Assay | BINDINGDB. | No reference |
IC50 (binding) | = 0.017 uM | Inhibition of human N-myristoyltransferase 1 assessed as transfer of [3H]-myristic acid to a biotinylated substrate peptide (GCGGSKVKPQPPQAK(biotin)-amide by scintillation proximity assay | ChEMBL. | 25412409 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma brucei | ChEMBL23 | 25412409 | |
Trypanosoma brucei gambiense | 25412409 | ||
Homo sapiens | ChEMBL23 | 25412409 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.