Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | serum/glucocorticoid regulated kinase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0027 | 0.2861 | 0.2861 |
Echinococcus granulosus | Glutaredoxin protein 5 | 0.0033 | 0.4787 | 0.977 |
Entamoeba histolytica | protein kinase, putative | 0.005 | 1 | 1 |
Schistosoma mansoni | egf-like domain protein | 0.0027 | 0.2861 | 0.5839 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0033 | 0.4899 | 0.4899 |
Giardia lamblia | Kinase, AGC PKA | 0.0033 | 0.4899 | 0.5 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0027 | 0.2861 | 0.2861 |
Trichomonas vaginalis | AGC family protein kinase | 0.005 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.2861 | 0.2861 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.2861 | 0.2861 |
Entamoeba histolytica | PH domain containing protein kinase, putative | 0.0033 | 0.4899 | 0.4899 |
Brugia malayi | Fibulin-1 precursor | 0.0027 | 0.2861 | 0.2861 |
Echinococcus multilocularis | nervana 2 | 0.0033 | 0.4787 | 0.977 |
Entamoeba histolytica | protein kinase 2, putative | 0.0033 | 0.4899 | 0.4899 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0027 | 0.2861 | 0.2861 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.2861 | 0.2861 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0033 | 0.4899 | 1 |
Echinococcus granulosus | sodium:potassium dependent atpase beta subunit | 0.0033 | 0.4787 | 0.977 |
Echinococcus multilocularis | rac serine:threonine kinase | 0.0033 | 0.4899 | 1 |
Plasmodium falciparum | RAC-beta serine/threonine protein kinase | 0.0033 | 0.4899 | 0.5 |
Echinococcus granulosus | nervana 2 | 0.0033 | 0.4787 | 0.977 |
Loa Loa (eye worm) | AGC/RSK/P70 protein kinase | 0.005 | 1 | 1 |
Echinococcus multilocularis | fibrillin 1 | 0.0027 | 0.2861 | 0.5839 |
Entamoeba histolytica | protein kinase, putative | 0.005 | 1 | 1 |
Echinococcus granulosus | nervana 2 | 0.0033 | 0.4787 | 0.977 |
Brugia malayi | Protein kinase domain containing protein | 0.005 | 1 | 1 |
Echinococcus multilocularis | serine threonine protein kinase nrc serine threonine protein kinase gad | 0.0033 | 0.4899 | 1 |
Echinococcus multilocularis | Glutaredoxin protein 5 | 0.0033 | 0.4787 | 0.977 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase | 0.0033 | 0.4899 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.005 | 1 | 1 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0027 | 0.2861 | 0.2861 |
Toxoplasma gondii | AGC kinase | 0.005 | 1 | 1 |
Echinococcus multilocularis | sodium:potassium dependent atpase beta subunit | 0.0033 | 0.4787 | 0.977 |
Trichomonas vaginalis | AGC family protein kinase | 0.005 | 1 | 1 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0033 | 0.4899 | 0.5 |
Echinococcus multilocularis | nervana 2 | 0.0033 | 0.4787 | 0.977 |
Trypanosoma cruzi | Protein kinase B | 0.0033 | 0.4899 | 0.5 |
Plasmodium vivax | rac-beta serine/threonine protein kinase, putative | 0.0033 | 0.4899 | 0.5 |
Schistosoma mansoni | serine/threonine-protein kinase | 0.0033 | 0.4899 | 1 |
Echinococcus granulosus | laminin | 0.0027 | 0.2861 | 0.5839 |
Loa Loa (eye worm) | AGC/AKT protein kinase | 0.005 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.005 | 1 | 1 |
Trypanosoma cruzi | rac serine-threonine kinase, putative | 0.0033 | 0.4899 | 0.5 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0027 | 0.2861 | 0.5839 |
Entamoeba histolytica | protein kinase, putative | 0.005 | 1 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.005 | 1 | 1 |
Onchocerca volvulus | Arrow homolog | 0.0027 | 0.2861 | 0.5 |
Echinococcus granulosus | Tolloid protein 1 | 0.0027 | 0.2861 | 0.5839 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.2861 | 0.2861 |
Echinococcus granulosus | serine threonine protein kinase nrc | 0.0033 | 0.4899 | 1 |
Trichomonas vaginalis | AGC family protein kinase | 0.005 | 1 | 1 |
Echinococcus granulosus | serine/threonine protein kinase | 0.0033 | 0.4899 | 1 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0027 | 0.2861 | 0.5839 |
Echinococcus multilocularis | laminin | 0.0027 | 0.2861 | 0.5839 |
Trichomonas vaginalis | AGC family protein kinase | 0.005 | 1 | 1 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0027 | 0.2861 | 0.2861 |
Trypanosoma brucei | rac serine-threonine kinase, putative | 0.005 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.2861 | 0.2861 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.0015 uM | Inhibition of SGK1 (unknown origin) assessed as substrate phosphorylation | ChEMBL. | 25589922 |
IC50 (binding) | = 0.05 uM | Inhibition of recombinant SGK1 (unknown origin) expressed in U2OS cells by cellular activity assay | ChEMBL. | 25589922 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.