Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma cruzi | Aph-1 protein, putative | 0.0484 | 0.3513 | 1 |
Brugia malayi | hypothetical protein | 0.0102 | 0.0246 | 0.0246 |
Echinococcus granulosus | presenilin enhancer 2 | 0.0196 | 0.1054 | 0.0829 |
Echinococcus granulosus | presenilin | 0.0209 | 0.1165 | 0.0942 |
Echinococcus multilocularis | presenilin enhancer 2 | 0.0196 | 0.1054 | 0.0829 |
Toxoplasma gondii | hypothetical protein | 0.0073 | 0 | 0.5 |
Echinococcus granulosus | gamma secretase subunit aph 1 | 0.1241 | 1 | 1 |
Leishmania major | presenilin-like aspartic peptidase, putative,presenilin-like aspartic peptidase, clan AD, family A22A, putative | 0.0209 | 0.1165 | 0.5 |
Entamoeba histolytica | presenilin 1 peptidase, putative | 0.0209 | 0.1165 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0102 | 0.0246 | 0.0246 |
Trypanosoma brucei | Aph-1 protein, putative | 0.0484 | 0.3513 | 1 |
Echinococcus multilocularis | presenilin | 0.0209 | 0.1165 | 0.0942 |
Loa Loa (eye worm) | gamma-secretase subunit aph-1 | 0.1241 | 1 | 1 |
Trypanosoma cruzi | Aph-1 protein, putative | 0.0484 | 0.3513 | 1 |
Brugia malayi | gamma-secretase subunit pen-2 | 0.0196 | 0.1054 | 0.1054 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0209 | 0.1165 | 1 |
Echinococcus multilocularis | gamma secretase subunit aph 1 | 0.1241 | 1 | 1 |
Schistosoma mansoni | gamma-secretase subunit aph-1 | 0.1241 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0102 | 0.0246 | 0.0246 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0209 | 0.1165 | 1 |
Schistosoma mansoni | subfamily A22A unassigned peptidase (A22 family) | 0.0209 | 0.1165 | 0.0942 |
Trichomonas vaginalis | Clan AD, family A22, presenilin-like aspartic peptidase | 0.0209 | 0.1165 | 1 |
Loa Loa (eye worm) | gamma-secretase subunit pen-2 | 0.0196 | 0.1054 | 0.1054 |
Brugia malayi | Presenilin family protein | 0.0209 | 0.1165 | 0.1165 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (ADMET) | = 1026 umol/L | Cytotoxicity against human WISH cells | ChEMBL. | 25515560 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.