Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | N-myristoyltransferase 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Probable pyruvate kinase PykA | 0.00683807 | 0.119863 | 0.5 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0141908 | 0.558302 | 0.498149 |
Toxoplasma gondii | pyruvate kinase PyK1 | 0.00683807 | 0.119863 | 0.5 |
Plasmodium vivax | glycylpeptide N-tetradecanoyltransferase, putative | 0.0215982 | 1 | 1 |
Brugia malayi | N-myristoyltransferase 2 | 0.0215982 | 1 | 1 |
Chlamydia trachomatis | pyruvate kinase | 0.00683807 | 0.119863 | 0.5 |
Trypanosoma brucei | N-myristoyltransferase | 0.0215982 | 1 | 1 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0215982 | 1 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.00683807 | 0.119863 | 0.5 |
Loa Loa (eye worm) | N-myristoyltransferase 2 | 0.0215982 | 1 | 1 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.00683807 | 0.119863 | 0.5 |
Schistosoma mansoni | N-myristoyltransferase | 0.0215982 | 1 | 1 |
Trichomonas vaginalis | N-myristoyl transferase, putative | 0.0215982 | 1 | 1 |
Entamoeba histolytica | glycylpeptide N-tetradecanoyltransferase, putative | 0.0215982 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.00683807 | 0.119863 | 0.119863 |
Trypanosoma brucei | N-myristoyl transferase, putative | 0.0215982 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.00683807 | 0.119863 | 0.119863 |
Echinococcus multilocularis | pyruvate kinase | 0.00683807 | 0.119863 | 0.0836734 |
Onchocerca volvulus | Pyruvate kinase homolog | 0.00683807 | 0.119863 | 0.5 |
Plasmodium falciparum | glycylpeptide N-tetradecanoyltransferase | 0.0215982 | 1 | 1 |
Leishmania major | N-myristoyl transferase, putative | 0.0215982 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00683807 | 0.119863 | 0.119863 |
Mycobacterium ulcerans | pyruvate kinase | 0.00683807 | 0.119863 | 0.5 |
Echinococcus multilocularis | glycylpeptide N tetradecanoyltransferase | 0.0215982 | 1 | 1 |
Trypanosoma cruzi | N-myristoyl transferase, putative | 0.0215982 | 1 | 1 |
Echinococcus multilocularis | pyruvate kinase | 0.00683807 | 0.119863 | 0.0836734 |
Giardia lamblia | CDC72 | 0.0215982 | 1 | 1 |
Mycobacterium tuberculosis | Probable pyruvate kinase PykA | 0.00683807 | 0.119863 | 0.5 |
Echinococcus granulosus | glycylpeptide N tetradecanoyltransferase | 0.0215982 | 1 | 1 |
Loa Loa (eye worm) | pyruvate kinase | 0.00683807 | 0.119863 | 0.119863 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
CL (ADMET) | = 4.2 ml/min/g | Intrinsic clearance in CD1 mouse liver microsomes at 0.5 uM in presence of NADPH incubated for 3 to 30 mins by UPLC-MS/MS method | ChEMBL. | 25412409 |
EC50 (functional) | = 0.01 uM | Antitrypanosomal activity against Trypanosoma brucei BSF427 expressing VSG118 infected in human MRC5 cells assessed as reduction cell viability incubated for 69 hrs by rezasurin dye based assay | ChEMBL. | 25412409 |
EC50 (ADMET) | = 7.2 uM | Antiproliferative activity against human MRC5 cells assessed as reduction cell viability incubated for 69 hrs by rezasurin dye based assay | ChEMBL. | 25412409 |
IC50 (binding) | = 145 nM | Enzyme Inhibition Assay | BINDINGDB. | No reference |
IC50 (binding) | = 0.16 uM | Inhibition of human N-myristoyltransferase 1 assessed as transfer of [3H]-myristic acid to a biotinylated substrate peptide (GCGGSKVKPQPPQAK(biotin)-amide by scintillation proximity assay | ChEMBL. | 25412409 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 25412409 | |
Trypanosoma brucei gambiense | 25412409 | ||
Trypanosoma brucei | ChEMBL23 | 25412409 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.