Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | norepinephrine transporter | 0.095 | 0.5 | 0.5 |
Loa Loa (eye worm) | serotonin transporter b | 0.095 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.095 | 0.5 | 0.5 |
Echinococcus granulosus | serotonin transporter | 0.095 | 0.5 | 0.5 |
Echinococcus multilocularis | serotonin transporter | 0.095 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.095 | 0.5 | 0.5 |
Schistosoma mansoni | norepinephrine/norepinephrine transporter | 0.095 | 0.5 | 0.5 |
Loa Loa (eye worm) | solute carrier family 6 member 4 | 0.095 | 0.5 | 0.5 |
Schistosoma mansoni | sodium/chloride dependent transporter | 0.095 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.095 | 0.5 | 0.5 |
Onchocerca volvulus | 0.095 | 0.5 | 0.5 | |
Treponema pallidum | sodium- and chloride- dependent transporter | 0.095 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | > 50 uM | Antiproliferative activity against human ER-negative MCF7 cells after 24 hrs by MTT assay | ChEMBL. | 25198997 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.