Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | peroxisome proliferator-activated receptor gamma | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | ecdysone induced protein 78C | peroxisome proliferator-activated receptor gamma | 477 aa | 447 aa | 28.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B | 0.0617 | 0.2791 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.1836 | 1 | 1 |
Trichomonas vaginalis | Clan SC, family S33, methylesterase-like serine peptidase | 0.0146 | 0 | 0.5 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S9B | 0.0617 | 0.2791 | 1 |
Entamoeba histolytica | hypothetical protein, conserved | 0.0146 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable peptidase | 0.0146 | 0 | 0.5 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0146 | 0 | 0.5 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.1836 | 1 | 1 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0146 | 0 | 0.5 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.1836 | 1 | 1 |
Toxoplasma gondii | dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein | 0.0617 | 0.2791 | 1 |
Brugia malayi | hypothetical protein | 0.0472 | 0.193 | 0.193 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0146 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0472 | 0.193 | 0.193 |
Giardia lamblia | Alanyl dipeptidyl peptidase | 0.0146 | 0 | 0.5 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0146 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable protease II PtrBb [second part] (oligopeptidase B) | 0.0146 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0146 | 0 | 0.5 |
Schistosoma mansoni | dipeptidyl-peptidase 9 (S09 family) | 0.0617 | 0.2791 | 0.2791 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.1836 | 1 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0617 | 0.2791 | 0.2791 |
Echinococcus granulosus | Dipeptidyl peptidase 9 | 0.0617 | 0.2791 | 0.2791 |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.1836 | 1 | 1 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0146 | 0 | 0.5 |
Entamoeba histolytica | dipeptidyl-peptidase, putative | 0.0146 | 0 | 0.5 |
Trichomonas vaginalis | Clan SC, family S9, acylaminoacyl-peptidase-like serine peptidase | 0.0146 | 0 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9B | 0.0617 | 0.2791 | 1 |
Echinococcus multilocularis | Dipeptidyl peptidase 9 | 0.0617 | 0.2791 | 0.2791 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0146 | 0 | 0.5 |
Trypanosoma cruzi | dipeptidyl-peptidase 8-like serine peptidase | 0.0617 | 0.2791 | 1 |
Entamoeba histolytica | prolyl oligopeptidase family protein | 0.0146 | 0 | 0.5 |
Trypanosoma brucei | Dipeptidyl-peptidase 8-like, putative | 0.0617 | 0.2791 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0146 | 0 | 0.5 |
Plasmodium falciparum | peptidase, putative | 0.0146 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (binding) | = 1.9 uM | Agonist activity at human PPARgamma expressed in HEK293 cells incubated for 18 hrs by luciferase reporter gene assay | ChEMBL. | 25333853 |
FC (binding) | = 1.6 | Agonist activity at human PPARgamma expressed in HEK293 cells assessed as induction of receptor activation at 10 uM incubated for 18 hrs by luciferase reporter gene assay relative to untreated control | ChEMBL. | 25333853 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.