Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | glutaminase 2 | 0.03 | 0.0681 | 0.5 |
Onchocerca volvulus | Putative sulfate transporter | 0.0224 | 0 | 0.5 |
Mycobacterium ulcerans | carbonic anhydrase | 0.0555 | 0.2965 | 0.2451 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0555 | 0.2965 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1339 | 1 | 1 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.0555 | 0.2965 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.0555 | 0.2965 | 1 |
Leishmania major | carbonic anhydrase family protein, putative | 0.0555 | 0.2965 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.1068 | 0.7572 | 1 |
Loa Loa (eye worm) | glutaminase | 0.03 | 0.0681 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0284 | 0.0537 | 0.031 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1339 | 1 | 1 |
Brugia malayi | glutaminase DH11.1 | 0.03 | 0.0681 | 0.5 |
Onchocerca volvulus | 0.0224 | 0 | 0.5 | |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.053 | 0.274 | 0.3344 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.