Detailed information for compound 949503

Basic information

Technical information
  • TDR Targets ID: 949503
  • Name: 5-(4-chlorophenyl)-2H-tetrazole
  • MW: 180.594 | Formula: C7H5ClN4
  • H donors: 1 H acceptors: 3 LogP: 1.84 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Clc1ccc(cc1)c1nnn[nH]1
  • InChi: 1S/C7H5ClN4/c8-6-3-1-5(2-4-6)7-9-11-12-10-7/h1-4H,(H,9,10,11,12)
  • InChiKey: BGKOVWIBDZMJPN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 5-(4-chlorophenyl)-2H-1,2,3,4-tetrazole
  • 16687-61-9
  • ST5408112
  • 6F-900
  • NSC86301
  • Bionet2_000295
  • AG-690/32526043

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis metabotropic glutamate receptor 5 0.0337 1 1
Loa Loa (eye worm) hypothetical protein 0.014 0.2606 0.2606
Schistosoma mansoni metabotropic glutamate receptor 2 3 (mglur group 2) 0.0311 0.9035 1
Plasmodium vivax gamma-glutamylcysteine synthetase, putative 0.0118 0.1796 0.5
Brugia malayi glutamate--cysteine ligase 0.0118 0.1796 0.2355
Loa Loa (eye worm) hypothetical protein 0.0102 0.1183 0.1183
Trypanosoma cruzi gamma-glutamylcysteine synthetase, putative 0.0118 0.1796 0.5
Schistosoma mansoni glutamate-cysteine ligase 0.0118 0.1796 0.0939
Loa Loa (eye worm) glutamate receptor 0.0274 0.7629 0.7629
Plasmodium falciparum gamma-glutamylcysteine synthetase 0.0118 0.1796 0.5
Schistosoma mansoni metabotropic glutamate receptor 0.0229 0.5964 0.6156
Echinococcus multilocularis n acetylated alpha linked acidic dipeptidase 2 0.015 0.298 0.1443
Schistosoma mansoni metabotropic glutamate receptor 0.0134 0.2371 0.1658
Toxoplasma gondii glutamate-cysteine ligase, catalytic subunit domain-containing protein 0.0118 0.1796 0.5
Loa Loa (eye worm) glutamate receptor 0.0108 0.1406 0.1406
Leishmania major gamma-glutamylcysteine synthetase, putative 0.0118 0.1796 0.5
Brugia malayi metabotropic glutamate receptor type 2 0.0134 0.2371 0.3107
Loa Loa (eye worm) hypothetical protein 0.0153 0.3117 0.3117
Loa Loa (eye worm) glutamate-cysteine ligase 0.0118 0.1796 0.1796
Echinococcus multilocularis metabotropic glutamate receptor 2 0.0229 0.5964 0.508
Giardia lamblia Glutamate-cysteine ligase 0.0118 0.1796 0.5
Trypanosoma brucei gamma-glutamylcysteine synthetase 0.0118 0.1796 0.5
Echinococcus granulosus metabotropic glutamate receptor 2 0.0229 0.5964 0.508
Trypanosoma cruzi gamma-glutamylcysteine synthetase, putative 0.0118 0.1796 0.5
Loa Loa (eye worm) hypothetical protein 0.0337 1 1
Brugia malayi Metabotropic glutamate receptor precursor. 0.0274 0.7629 1
Brugia malayi metabotropic glutamate receptor subtype 5a (mGluR5a), putative 0.0248 0.6665 0.8736

Activities

Activity type Activity value Assay description Source Reference
Activity (binding) Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.08 ug/ml after 2 hrs by fluorescence microscopy ChEMBL. 18835718
Activity (binding) Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 0.4 ug/ml after 2 hrs by fluorescence microscopy ChEMBL. 18835718
Activity (binding) Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 2 ug/ml after 2 hrs by fluorescence microscopy ChEMBL. 18835718
Activity (binding) Inhibition of CRM1-mediated nucleocytoplasmic transport of RevM5 mutant in HEK293 cells assessed as RevM5-GFP nuclear localization at 10 ug/ml after 2 hrs by fluorescence microscopy ChEMBL. 18835718
Kd (binding) = 1850 uM Binding affinity to human RPA70N assessed as inhibition of interaction with FITC-Ahx-DFTADDLEELDTLAS-NH2 after 1 hr by fluorescence polarization anisotropy assay ChEMBL. 23914285
Kd (binding) = 1850 uM Binding affinity to RPA70N (1 to 120) site1 (unknown origin) expressed in Escherichia coli BL21-DE3 cells by NMR spectroscopy ChEMBL. 24147804

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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