Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0107 | 0.0332 | 0.2747 |
Plasmodium vivax | SET domain protein, putative | 0.0063 | 0.0017 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0114 | 0.0381 | 0.3172 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0063 | 0.0017 | 1 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0063 | 0.0017 | 0.5 |
Brugia malayi | SET domain containing protein | 0.0116 | 0.0398 | 0.3319 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0063 | 0.0017 | 0.5 |
Mycobacterium tuberculosis | Mycothiol conjugate amidase Mca (mycothiol S-conjugate amidase) | 0.1394 | 0.9655 | 0.5 |
Trichomonas vaginalis | set domain proteins, putative | 0.0283 | 0.1606 | 0.5 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0177 | 0.0839 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0222 | 0.1165 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0063 | 0.0017 | 0.5 |
Onchocerca volvulus | 0.0283 | 0.1606 | 1 | |
Mycobacterium ulcerans | mycothiol conjugate amidase Mca | 0.1442 | 1 | 0.5 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0222 | 0.1165 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.