Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0419 | 0.209 | 0.209 |
Brugia malayi | Rhodanese-like domain containing protein | 0.1414 | 1 | 1 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0419 | 0.209 | 0.209 |
Loa Loa (eye worm) | hypothetical protein | 0.1304 | 0.9122 | 0.9122 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.1414 | 1 | 0.5 |
Trichomonas vaginalis | m-phase inducer phosphatase, putative | 0.1414 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1414 | 1 | 1 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.1414 | 1 | 0.5 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.1414 | 1 | 0.5 |
Onchocerca volvulus | 0.1414 | 1 | 0.5 | |
Trichomonas vaginalis | cdc25b, putative | 0.1414 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1304 | 0.9122 | 0.9122 |
Echinococcus granulosus | m phase inducer phosphatasecdc25 | 0.1414 | 1 | 1 |
Schistosoma mansoni | m-phase inducer phosphatase(cdc25) | 0.1414 | 1 | 1 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.1414 | 1 | 0.5 |
Onchocerca volvulus | 0.1414 | 1 | 0.5 | |
Onchocerca volvulus | 0.1414 | 1 | 0.5 | |
Trichomonas vaginalis | m-phase inducer phosphatase, putative | 0.1414 | 1 | 0.5 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0419 | 0.209 | 0.209 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.1414 | 1 | 0.5 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.1414 | 1 | 0.5 |
Trichomonas vaginalis | cdc25c, putative | 0.1414 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1414 | 1 | 1 |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0419 | 0.209 | 0.209 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0419 | 0.209 | 0.209 |
Echinococcus multilocularis | m phase inducer phosphatase(cdc25) | 0.1414 | 1 | 1 |
Onchocerca volvulus | 0.1414 | 1 | 0.5 | |
Trichomonas vaginalis | cdc25b, putative | 0.1414 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | > 1000 uM | Inhibition of human DNA topoisomerase 2alpha using plasmid pNO1 substrate incubated at 37 degC for 30 mins by fluorimetry | ChEMBL. | 25453816 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.