Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.161782 | 1 | 0.5 |
Onchocerca volvulus | 0.161782 | 1 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.148263 | 0.905465 | 0.905465 |
Brugia malayi | Rhodanese-like domain containing protein | 0.161782 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.148263 | 0.905465 | 0.905465 |
Loa Loa (eye worm) | hypothetical protein | 0.161782 | 1 | 1 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.161782 | 1 | 0.5 |
Schistosoma mansoni | protein tyrosine phosphatase non-receptor type nt1 | 0.0389007 | 0.140723 | 0.140723 |
Brugia malayi | Rhodanese-like domain containing protein | 0.161782 | 1 | 1 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.161782 | 1 | 0.5 |
Onchocerca volvulus | 0.161782 | 1 | 0.5 | |
Echinococcus granulosus | tyrosine protein phosphatase non receptor type | 0.0389007 | 0.140723 | 0.140723 |
Trichomonas vaginalis | cdc25b, putative | 0.161782 | 1 | 0.5 |
Loa Loa (eye worm) | protein-tyrosine phosphatase | 0.0389007 | 0.140723 | 0.140723 |
Loa Loa (eye worm) | hypothetical protein | 0.161782 | 1 | 1 |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.161782 | 1 | 0.5 |
Trichomonas vaginalis | m-phase inducer phosphatase, putative | 0.161782 | 1 | 0.5 |
Trichomonas vaginalis | mitotic inducer phosphatase CDC25, putative | 0.161782 | 1 | 0.5 |
Echinococcus granulosus | m phase inducer phosphatasecdc25 | 0.161782 | 1 | 1 |
Onchocerca volvulus | 0.161782 | 1 | 0.5 | |
Onchocerca volvulus | 0.161782 | 1 | 0.5 | |
Entamoeba histolytica | rodhanase-like domain containing protein | 0.161782 | 1 | 0.5 |
Echinococcus multilocularis | m phase inducer phosphatase(cdc25) | 0.161782 | 1 | 1 |
Trichomonas vaginalis | m-phase inducer phosphatase, putative | 0.161782 | 1 | 0.5 |
Echinococcus multilocularis | tyrosine protein phosphatase non receptor type | 0.0389007 | 0.140723 | 0.140723 |
Brugia malayi | Protein-tyrosine phosphatase containing protein | 0.0389007 | 0.140723 | 0.140723 |
Trichomonas vaginalis | cdc25c, putative | 0.161782 | 1 | 0.5 |
Schistosoma mansoni | m-phase inducer phosphatase(cdc25) | 0.161782 | 1 | 1 |
Trichomonas vaginalis | cdc25b, putative | 0.161782 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 396 nM | Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as growth inhibition after 72 hrs by DAPI staining | ChEMBL. | 22686608 |
IC50 (ADMET) | = 1100 nM | Cytotoxicity against human HEK293 cells assessed as growth inhibition after 72 hrs by Alamar blue assay | ChEMBL. | 22686608 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 22686608 | |
Plasmodium falciparum | ChEMBL23 | 22686608 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.