Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | hypothetical protein | 0.0011 | 0.198 | 0.198 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0003 | 0 | 0.5 |
Echinococcus granulosus | semaphorin 1A | 0.0008 | 0.1165 | 0.1165 |
Schistosoma mansoni | plexin | 0.0011 | 0.198 | 0.198 |
Loa Loa (eye worm) | plexin A | 0.0022 | 0.4961 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0019 | 0.4053 | 0.8169 |
Trichomonas vaginalis | Clan MA, family M8, leishmanolysin-like metallopeptidase | 0.0003 | 0 | 0.5 |
Echinococcus multilocularis | calcium:calmodulin dependent protein kinase I | 0.0041 | 0.9996 | 0.9996 |
Brugia malayi | plexin A | 0.0022 | 0.4961 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0041 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0041 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.1165 | 0.2348 |
Brugia malayi | hypothetical protein | 0.0008 | 0.1165 | 0.2348 |
Echinococcus granulosus | calcium:calmodulin dependent protein kinase I | 0.0041 | 0.9996 | 0.9996 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0003 | 0 | 0.5 |
Brugia malayi | Sema domain containing protein | 0.0008 | 0.1165 | 0.2348 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.1165 | 0.2348 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0003 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0003 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.1165 | 0.2348 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0004 | 0.0243 | 0.0243 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0041 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0008 | 0.1165 | 0.1165 |
Echinococcus multilocularis | hypothetical protein | 0.0008 | 0.1165 | 0.1165 |
Brugia malayi | Plexin repeat family protein | 0.0019 | 0.4053 | 0.8169 |
Trichomonas vaginalis | Clan MA, family M8, leishmanolysin-like metallopeptidase | 0.0003 | 0 | 0.5 |
Loa Loa (eye worm) | sema domain-containing protein | 0.0008 | 0.1165 | 0.2348 |
Entamoeba histolytica | tyrosin kinase, putative | 0.0004 | 0.0243 | 0.0243 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0003 | 0 | 0.5 |
Brugia malayi | Sema domain containing protein | 0.0008 | 0.1165 | 0.2348 |
Echinococcus multilocularis | serine:threonine protein kinase Chk2 | 0.0041 | 1 | 1 |
Trichomonas vaginalis | Clan MA, family M8, leishmanolysin-like metallopeptidase | 0.0003 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.1165 | 0.2348 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0003 | 0 | 0.5 |
Echinococcus granulosus | semaphorin 5B | 0.0008 | 0.1165 | 0.1165 |
Echinococcus granulosus | plexin a4 | 0.0022 | 0.4961 | 0.4961 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.1165 | 0.2348 |
Trichomonas vaginalis | Clan MA, family M8, leishmanolysin-like metallopeptidase | 0.0003 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0008 | 0.1165 | 0.2348 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0003 | 0 | 0.5 |
Brugia malayi | hypothetical protein | 0.0008 | 0.1165 | 0.2348 |
Trichomonas vaginalis | Clan MA, family M8, leishmanolysin-like metallopeptidase | 0.0003 | 0 | 0.5 |
Schistosoma mansoni | semaphorin 5-related | 0.0008 | 0.1165 | 0.1165 |
Onchocerca volvulus | 0.0019 | 0.4053 | 1 | |
Echinococcus multilocularis | semaphorin 5B | 0.0008 | 0.1165 | 0.1165 |
Schistosoma mansoni | plexin | 0.0019 | 0.4053 | 0.4053 |
Schistosoma mansoni | hypothetical protein | 0.0008 | 0.1165 | 0.1165 |
Loa Loa (eye worm) | hypothetical protein | 0.0011 | 0.198 | 0.3991 |
Echinococcus multilocularis | plexin a4 | 0.0022 | 0.4961 | 0.4961 |
Loa Loa (eye worm) | sema domain-containing protein | 0.0008 | 0.1165 | 0.2348 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 30 % | Inhibition of human NPP1 using p-Nph-5'-TMP as substrate at 10 uM | ChEMBL. | 25372276 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.