Detailed information for compound 954999

Basic information

Technical information
  • TDR Targets ID: 954999
  • Name: 2-hydroxy-N-(5-methyl-1,3-thiazol-2-yl)benzam ide
  • MW: 234.274 | Formula: C11H10N2O2S
  • H donors: 2 H acceptors: 3 LogP: 2.72 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1cnc(s1)NC(=O)c1ccccc1O
  • InChi: 1S/C11H10N2O2S/c1-7-6-12-11(16-7)13-10(15)8-4-2-3-5-9(8)14/h2-6,14H,1H3,(H,12,13,15)
  • InChiKey: YLTAAMUGGIYNJU-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-hydroxy-N-(5-methylthiazol-2-yl)benzamide
  • 2-hydroxy-N-(5-methyl-2-thiazolyl)benzamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.1091 0.1647 1
Brugia malayi Nuclear hormone receptor family member nhr-25 0.008 0.0066 0.0403
Loa Loa (eye worm) hypothetical protein 0.0071 0.0052 0.0318
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0042 0.0007 0.0043
Plasmodium vivax kinesin-5 0.0835 0.1248 0.5
Onchocerca volvulus Bile acid receptor homolog 0.008 0.0066 1
Brugia malayi hypothetical protein 0.0042 0.0007 0.0043
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.008 0.0066 0.0066
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0104 0.0104 0.0631
Schistosoma mansoni retinoic acid receptor RXR 0.008 0.0066 0.0076
Echinococcus multilocularis ecdysone induced protein 78C 0.008 0.0066 0.0066
Loa Loa (eye worm) hypothetical protein 0.008 0.0066 0.0403
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.008 0.0066 0.0066
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0042 0.0007 0.0007
Echinococcus multilocularis thyroid hormone receptor alpha 0.008 0.0066 0.0066
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0007 0.0043
Entamoeba histolytica kinesin, putative 0.0835 0.1248 0.5
Echinococcus multilocularis geminin 0.0355 0.0496 0.0496
Loa Loa (eye worm) steroid hormone receptor 0.008 0.0066 0.0403
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.008 0.0066 0.0066
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0933 0.14 0.8499
Schistosoma mansoni Tr4/Tr2 (homologue) 0.008 0.0066 0.0076
Brugia malayi nuclear receptor RXR 0.0042 0.0007 0.0043
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.008 0.0066 0.0076
Echinococcus multilocularis kinesin family 1 0.643 1 1
Brugia malayi RNA recognition motif domain containing protein 0.0133 0.0148 0.09
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.008 0.0066 0.0403
Loa Loa (eye worm) hypothetical protein 0.0557 0.0813 0.4935
Brugia malayi Nuclear hormone receptor family member nhr-19 0.008 0.0066 0.0403
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0133 0.0148 0.09
Echinococcus granulosus geminin 0.0355 0.0496 0.0496
Brugia malayi Calcitonin receptor-like protein seb-1 0.0104 0.0104 0.0631
Loa Loa (eye worm) hypothetical protein 0.0104 0.0104 0.0631
Schistosoma mansoni coup transcription factor 0.008 0.0066 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-41 0.008 0.0066 0.0403
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.008 0.0066 0.0403
Schistosoma mansoni hypothetical protein 0.0071 0.0052 0.006
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0042 0.0007 0.0008
Brugia malayi Nuclear hormone receptor family member nhr-14 0.008 0.0066 0.0403
Schistosoma mansoni tar DNA-binding protein 0.0133 0.0148 0.017
Brugia malayi hypothetical protein 0.0042 0.0007 0.0043
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.008 0.0066 1
Brugia malayi ecdysteroid receptor 0.008 0.0066 0.0403
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.008 0.0066 0.0403
Loa Loa (eye worm) hypothetical protein 0.008 0.0066 0.0403
Schistosoma mansoni thyroid hormone receptor 0.008 0.0066 0.0076
Loa Loa (eye worm) hypothetical protein 0.0042 0.0007 0.0043
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.008 0.0066 0.0066
Brugia malayi latrophilin 2 splice variant baaae 0.0071 0.0052 0.0318
Schistosoma mansoni tar DNA-binding protein 0.0133 0.0148 0.017
Brugia malayi Nuclear hormone receptor-like 1 0.008 0.0066 0.0403
Loa Loa (eye worm) hypothetical protein 0.0042 0.0007 0.0043
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.008 0.0066 0.0076
Loa Loa (eye worm) kinesin-like protein KLP2 0.0835 0.1248 0.7575
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.008 0.0066 0.0076
Schistosoma mansoni tar DNA-binding protein 0.0133 0.0148 0.017
Brugia malayi nuclear hormone receptor 0.008 0.0066 0.0403
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.089 0.1333 0.1534
Loa Loa (eye worm) hypothetical protein 0.0042 0.0007 0.0043
Schistosoma mansoni steroid hormone receptor ad4bp 0.008 0.0066 0.0076
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.008 0.0066 0.0066
Brugia malayi Steroid receptor seven-up type 2 0.008 0.0066 0.0403
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.008 0.0066 0.0403
Schistosoma mansoni tar DNA-binding protein 0.0133 0.0148 0.017
Loa Loa (eye worm) hypothetical protein 0.008 0.0066 0.0403
Leishmania major C-8 sterol isomerase-like protein 0.1091 0.1647 0.5
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.008 0.0066 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0933 0.14 0.8499
Schistosoma mansoni hypothetical protein 0.5595 0.8693 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0066 0.0403
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0042 0.0007 0.0007
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0042 0.0007 0.0008
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.008 0.0066 0.0403
Toxoplasma gondii kinesin motor domain-containing protein 0.0835 0.1248 0.5
Echinococcus granulosus FTZ F1 alpha 0.008 0.0066 0.0066
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0933 0.14 0.14
Loa Loa (eye worm) hypothetical protein 0.0042 0.0007 0.0043
Schistosoma mansoni tar DNA-binding protein 0.0133 0.0148 0.017
Giardia lamblia Kinesin-5 0.0835 0.1248 0.5
Schistosoma mansoni RAR-like nuclear receptor 0.008 0.0066 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-3 0.008 0.0066 0.0403
Trypanosoma cruzi C-8 sterol isomerase, putative 0.1091 0.1647 0.5
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.008 0.0066 0.0403
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.008 0.0066 0.0403
Loa Loa (eye worm) RNA binding protein 0.0133 0.0148 0.09
Echinococcus granulosus nuclear receptor 2DBD gamma 0.008 0.0066 0.0066
Echinococcus multilocularis tar DNA binding protein 0.0133 0.0148 0.0148
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.008 0.0066 0.0403
Echinococcus granulosus tar DNA binding protein 0.0133 0.0148 0.0148
Brugia malayi Nuclear hormone receptor family member nhr-25 0.008 0.0066 0.0403
Loa Loa (eye worm) hypothetical protein 0.008 0.0066 0.0403
Echinococcus multilocularis FTZ F1 alpha 0.008 0.0066 0.0066
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.008 0.0066 0.0066
Brugia malayi steroid hormone receptor 0.008 0.0066 0.0403
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.008 0.0066 0.0076
Trypanosoma brucei C-8 sterol isomerase, putative 0.1091 0.1647 0.5
Schistosoma mansoni hypothetical protein 0.0355 0.0496 0.057
Brugia malayi RNA binding protein 0.0133 0.0148 0.09
Brugia malayi nuclear receptor NHR-88 0.008 0.0066 0.0403
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0104 0.0104 0.0631
Brugia malayi Nuclear hormone receptor family member nhr-31 0.008 0.0066 0.0403
Loa Loa (eye worm) hypothetical protein 0.008 0.0066 0.0403
Brugia malayi Kinesin motor domain containing protein 0.0835 0.1248 0.7575
Brugia malayi Nuclear hormone receptor family member nhr-1 0.008 0.0066 0.0403
Loa Loa (eye worm) hypothetical protein 0.008 0.0066 0.0403
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0933 0.14 0.14
Loa Loa (eye worm) TAR-binding protein 0.0133 0.0148 0.09
Brugia malayi Nuclear hormone receptor family member nhr-19 0.008 0.0066 0.0403
Schistosoma mansoni kinesin eg-5 0.0835 0.1248 0.1435
Echinococcus granulosus ecdysone induced protein 78C 0.008 0.0066 0.0066
Brugia malayi Nuclear hormone receptor family member nhr-40 0.008 0.0066 0.0403
Schistosoma mansoni hypothetical protein 0.0355 0.0496 0.057
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.008 0.0066 0.0066
Brugia malayi ERG2 and Sigma1 receptor like protein 0.1091 0.1647 1
Plasmodium falciparum kinesin-5 0.0835 0.1248 0.5
Echinococcus granulosus retinoic acid receptor rxr beta a 0.008 0.0066 0.0066
Brugia malayi photoreceptor-specific nuclear receptor 0.008 0.0066 0.0403
Echinococcus granulosus nuclear receptor 2DBD gamma 0.008 0.0066 0.0066
Schistosoma mansoni retinoid-x-receptor (RXR) 0.008 0.0066 0.0076
Schistosoma mansoni thyroid hormone receptor 0.008 0.0066 0.0076
Brugia malayi TAR-binding protein 0.0133 0.0148 0.09
Schistosoma mansoni nuclear hormone receptor 0.008 0.0066 0.0076
Brugia malayi Nuclear hormone receptor-like 1 0.0042 0.0007 0.0043
Onchocerca volvulus 0.008 0.0066 1
Loa Loa (eye worm) hypothetical protein 0.008 0.0066 0.0403
Loa Loa (eye worm) hypothetical protein 0.0042 0.0007 0.0043
Onchocerca volvulus Protein ultraspiracle homolog 0.008 0.0066 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) Antiparasitic activity against Cryptosporidium parvum infected in human HTC8 cells after 46 hrs by immunofluorescence method ChEMBL. 20047919
IC50 (functional) > 10 mg/L Antiparasitic activity against Cryptosporidium parvum infected in human HTC8 cells after 46 hrs by immunofluorescence method ChEMBL. 20047919

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Cryptosporidium parvum ChEMBL23 20047919

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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