Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | Rac GTPase activating protein 1 | 0.0078 | 1 | 1 |
Loa Loa (eye worm) | RhoGAP domain-containing protein | 0.0011 | 0.0016 | 0.0016 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.562 | 0.562 |
Loa Loa (eye worm) | hypothetical protein | 0.0067 | 0.8413 | 0.8413 |
Schistosoma mansoni | rac gtpase activating protein | 0.0078 | 1 | 1 |
Onchocerca volvulus | 0.0011 | 0 | 0.5 | |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0048 | 0.562 | 0.562 |
Onchocerca volvulus | 0.0011 | 0 | 0.5 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.562 | 0.562 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0048 | 0.562 | 0.562 |
Entamoeba histolytica | diacylglycerol kinase, putative | 0.0011 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.562 | 0.562 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.562 | 0.562 |
Entamoeba histolytica | diacylglycerol kinase, putative | 0.0011 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0048 | 0.562 | 0.562 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0048 | 0.562 | 0.562 |
Schistosoma mansoni | chimerin-related rho-gtpase-activating protein | 0.0011 | 0.0016 | 0.0016 |
Echinococcus multilocularis | N chimaerin | 0.0011 | 0.0016 | 0.0016 |
Giardia lamblia | Rho GAP, putative | 0.0067 | 0.8413 | 0.5 |
Onchocerca volvulus | 0.0011 | 0 | 0.5 | |
Brugia malayi | RhoGAP domain containing protein | 0.0067 | 0.8413 | 0.8413 |
Echinococcus granulosus | N chimaerin | 0.0011 | 0.0016 | 0.0016 |
Schistosoma mansoni | chimerin-related rho-gtpase-activating protein | 0.0011 | 0.0016 | 0.0016 |
Echinococcus multilocularis | Rac GTPase activating protein 1 | 0.0078 | 1 | 1 |
Brugia malayi | RhoGAP domain containing protein | 0.0011 | 0.0016 | 0.0016 |
Toxoplasma gondii | diacylglycerol kinase, putative | 0.0011 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0011 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0078 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0048 | 0.562 | 0.562 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.12 uM | Antileishmanial activity against Leishmania donovani LD-1S/MHOM/SD/00-strain 1S amastigotes | ChEMBL. | 19007286 |
IC50 (functional) | > 10 uM | Antitrypanosomal activity against Trypanosoma cruzi | ChEMBL. | 19007286 |
IC50 (functional) | = 16.5 uM | Antimalarial activity against Plasmodium falciparum | ChEMBL. | 19007286 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 19007286 | |
Leishmania donovani | ChEMBL23 | 19007286 | |
Trypanosoma cruzi | ChEMBL23 | 19007286 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.