Detailed view for LOAG_00045

Basic information

TDR Targets ID: 946234
Loa Loa (eye worm), hypothetical protein
Source Database / ID:  KEGG  

pI: 8.4654 | Length (AA): 696 | MW (Da): 79401 | Paralog Number: 1

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG2

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00130   Phorbol esters/diacylglycerol binding domain (C1 domain)
PF00620   RhoGAP domain

Gene Ontology

Mouse over links to read term descriptions.
GO:0035556   GO:intracellular signal transduction  

GO:0007165   signal transduction  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 4 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
353 412 4b6d (A) 279 337 37.00 0 0.38 0.407207 0.14
427 594 3iug (A) 374 566 23.00 0 1 0.642379 -1.87
427 665 2mbg (A) 198 424 17.00 0 1 0.526391 -0.59
434 578 5jd0 (A) 915 1065 31.00 0 1 0.669333 -1.48

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_132551)

Species Accession Gene Product
Brugia malayi Bm1_52695   RhoGAP domain containing protein
Brugia malayi Bm1_52690   RhoGAP domain containing protein
Caenorhabditis elegans CELE_K08E3.6   Protein CYK-4
Drosophila melanogaster Dmel_CG13345   tumbleweed
Echinococcus granulosus EgrG_000652000   Rac GTPase activating protein 1
Echinococcus multilocularis EmuJ_000652000   Rac GTPase activating protein 1
Giardia lamblia GL50803_13550   Rho GAP, putative
Homo sapiens ENSG00000161800   Rac GTPase activating protein 1
Loa Loa (eye worm) LOAG_00045   hypothetical protein
Loa Loa (eye worm) LOAG_00046   hypothetical protein
Mus musculus ENSMUSG00000023015   Rac GTPase-activating protein 1
Schistosoma japonicum Sjp_0128440   expressed protein
Schistosoma japonicum Sjp_0133670   IPR000437,Prokaryotic membrane lipoprotein lipid attachment site;IPR008936,Rho GTPase activation protein,domain-containing
Schistosoma japonicum Sjp_0001730   Rac GTPase-activating protein 1, putative
Schistosoma mansoni Smp_021590   rac gtpase activating protein
Schmidtea mediterranea mk4.006217.00  
Schmidtea mediterranea mk4.014474.00  

Essentiality

LOAG_00045 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
CELE_K08E3.6 Caenorhabditis elegans embryonic lethal wormbase
CELE_K08E3.6 Caenorhabditis elegans sterile wormbase
Show/Hide essentiality data references
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens Rac GTPase activating protein 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0089 1 1
0.0077 0.386 0.3921
0.0071 0.2949 0.2949
0.0078 1 1
0.0075 0.361 0.361
0.0089 0.5879 0.5879
0.0089 0.3936 0.3998
0.0089 0.4215 0.4215
0.0089 0.4156 0.4328
0.0089 1 1
0.0081 0.7985 0.7985
0.0073 0.3131 0.3131
0.0086 0.2522 0.2932
0.0072 0.2801 0.5802
0.0089 0.3978 1
0.0077 0.386 0.3921
0.0089 0.7985 0.7985
0.0089 0.5336 0.5336
0.008 0.2761 0.2761
0.0089 1 1
0.0084 0.2798 0.3205
0.0075 0.276 0.276
0.0089 0.387 0.3858
0.0082 0.6514 0.6514
0.0071 0.2862 0.2862
0.0089 0.3759 1
0.0071 0.2793 0.2793
0.0089 0.8132 0.8132
0.0075 1 1
0.008 0.5129 0.5129
0.0073 0.3131 0.3131
0.0078 0.3768 0.3768
0.0073 0.2655 0.2655
0.0089 0.2971 0.3391
0.0072 0.2793 0.2793
0.0053 0.3936 0.3998
0.0089 0.5802 0.5802
0.0074 0.304 0.4915
0.0084 0.2798 0.3205
0.0077 0.4167 0.4167
0.0074 0.387 0.3858
0.0071 0.2949 0.2949
0.0073 0.3131 0.3131
0.0085 0.3951 0.58
0.0089 1 1
0.0089 1 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

No user comments are available for this gene. Log in to add comments, or register.

Enter your comment

User ()
Gene identifier LOAG_00045 (Loa Loa (eye worm)), hypothetical protein
Title for this comment
Comment