Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | mitogen-activated protein kinase-activated protein kinase 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | serine/threonine protein kinase | Get druggable targets OG5_131483 | All targets in OG5_131483 |
Echinococcus multilocularis | MAP kinase activated protein kinase 2 | Get druggable targets OG5_131483 | All targets in OG5_131483 |
Brugia malayi | map kinase activated protein kinase protein 2 | Get druggable targets OG5_131483 | All targets in OG5_131483 |
Loa Loa (eye worm) | camk/mapkapk/mapkapk protein kinase | Get druggable targets OG5_131483 | All targets in OG5_131483 |
Schistosoma japonicum | ko:K04443 mitogen-activated protein kinase-activated protein kinase 2, putative | Get druggable targets OG5_131483 | All targets in OG5_131483 |
Echinococcus granulosus | MAP kinase activated protein kinase 2 | Get druggable targets OG5_131483 | All targets in OG5_131483 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma brucei | mitogen-activated protein kinase 5 | mitogen-activated protein kinase-activated protein kinase 2 | 370 aa | 303 aa | 26.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | DNA topoisomerase II | 0.0051 | 0.1335 | 0.5 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0123 | 0.437 | 0.3378 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0055 | 0.1499 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0097 | 0.3295 | 1 |
Loa Loa (eye worm) | camk/mapkapk/mapkapk protein kinase | 0.0217 | 0.8407 | 1 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0055 | 0.1499 | 0.1442 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0122 | 0.4324 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.008 | 0.2574 | 0.236 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0055 | 0.1499 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0097 | 0.3295 | 1 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0055 | 0.1499 | 0.1442 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0097 | 0.3295 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0123 | 0.437 | 0.4208 |
Loa Loa (eye worm) | intermediate filament protein | 0.0028 | 0.0335 | 0.0399 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0335 | 0.0399 |
Echinococcus granulosus | MAP kinase activated protein kinase 2 | 0.0217 | 0.8407 | 1 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0255 | 1 | 1 |
Schistosoma mansoni | DNA topoisomerase II | 0.0055 | 0.1499 | 0.1442 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0055 | 0.1499 | 0.1783 |
Brugia malayi | Probable DNA topoisomerase II | 0.0055 | 0.1499 | 0.1442 |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0255 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.028 | 0.0333 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0217 | 0.8407 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0097 | 0.3295 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0055 | 0.1499 | 0.5 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0255 | 1 | 1 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0071 | 0.2169 | 0.0788 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0055 | 0.1499 | 1 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0055 | 0.1499 | 0.1442 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0055 | 0.1499 | 0.1442 |
Brugia malayi | map kinase activated protein kinase protein 2 | 0.0217 | 0.8407 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0055 | 0.1499 | 1 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0255 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0255 | 1 | 1 |
Echinococcus multilocularis | MAP kinase activated protein kinase 2 | 0.0217 | 0.8407 | 1 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0028 | 0.0335 | 0.0399 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.0314 | 0.0373 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0255 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.028 | 0.0333 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0255 | 1 | 1 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0123 | 0.437 | 0.3378 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.2 uM | Inhibition of human MK2 | ChEMBL. | 18945615 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.