Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | Kazal-type serine protease inhibitor domain-containing protein | 0.00360767 | 0.473735 | 0.473735 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.00182834 | 0 | 0.5 |
Onchocerca volvulus | 0.00558431 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.00558431 | 1 | 1 |
Treponema pallidum | ATP-dependent RNA helicase | 0.00182834 | 0 | 0.5 |
Loa Loa (eye worm) | kazal-type serine protease inhibitor domain-containing protein | 0.00360767 | 0.473735 | 0.473735 |
Loa Loa (eye worm) | agrin synaptic family protein | 0.00360767 | 0.473735 | 0.473735 |
Loa Loa (eye worm) | hypothetical protein | 0.00558431 | 1 | 1 |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.00558431 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00558431 | 1 | 1 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.00182834 | 0 | 0.5 |
Leishmania major | eukaryotic initiation factor 4a, putative | 0.00182834 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00360767 | 0.473735 | 0.473735 |
Plasmodium vivax | RNA helicase-1, putative | 0.00182834 | 0 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.00182834 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00558431 | 1 | 1 |
Echinococcus multilocularis | follistatin | 0.00360767 | 0.473735 | 0.473735 |
Brugia malayi | hypothetical protein | 0.00558431 | 1 | 1 |
Trypanosoma brucei | Eukaryotic initiation factor 4A-1 | 0.00182834 | 0 | 0.5 |
Onchocerca volvulus | 0.00558431 | 1 | 1 | |
Onchocerca volvulus | 0.00558431 | 1 | 1 | |
Onchocerca volvulus | Putative organic anion transporter | 0.00558431 | 1 | 1 |
Toxoplasma gondii | protease inhibitor PI2 | 0.00360767 | 0.473735 | 0.473735 |
Echinococcus multilocularis | expressed protein | 0.00360767 | 0.473735 | 0.473735 |
Brugia malayi | Kazal-type serine protease inhibitor domain containing protein | 0.00360767 | 0.473735 | 0.473735 |
Mycobacterium tuberculosis | Probable cold-shock DeaD-box protein A homolog DeaD (ATP-dependent RNA helicase dead homolog) | 0.00182834 | 0 | 0.5 |
Trichomonas vaginalis | DEAD box ATP-dependent RNA helicase, putative | 0.00182834 | 0 | 0.5 |
Toxoplasma gondii | Kazal-type serine protease inhibitor domain-containing protein | 0.00360767 | 0.473735 | 0.473735 |
Trypanosoma cruzi | MFS transporter, putative | 0.00558431 | 1 | 1 |
Onchocerca volvulus | Putative organic anion transporter | 0.00558431 | 1 | 1 |
Echinococcus granulosus | Solute carrier organic anion transporter family | 0.00558431 | 1 | 1 |
Toxoplasma gondii | Kazal-type serine protease inhibitor domain-containing protein | 0.00360767 | 0.473735 | 0.473735 |
Echinococcus granulosus | organic anion transporting polypeptide 30B | 0.00558431 | 1 | 1 |
Onchocerca volvulus | Putative organic anion transporter | 0.00558431 | 1 | 1 |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.00558431 | 1 | 1 |
Echinococcus multilocularis | agrin | 0.00360767 | 0.473735 | 0.473735 |
Brugia malayi | sodium-independent organic anion transporter family protein | 0.00558431 | 1 | 1 |
Schistosoma mansoni | follistatin | 0.00360767 | 0.473735 | 0.473735 |
Loa Loa (eye worm) | hypothetical protein | 0.00360767 | 0.473735 | 0.473735 |
Brugia malayi | Kazal-type serine protease inhibitor domain containing protein | 0.00360767 | 0.473735 | 0.473735 |
Brugia malayi | secreted modular calcium-binding protein 1 | 0.00360767 | 0.473735 | 0.473735 |
Onchocerca volvulus | 0.00558431 | 1 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.00558431 | 1 | 1 |
Echinococcus multilocularis | Solute carrier organic anion transporter family | 0.00558431 | 1 | 1 |
Echinococcus granulosus | agrin | 0.00360767 | 0.473735 | 0.473735 |
Schistosoma mansoni | agrin | 0.00360767 | 0.473735 | 0.473735 |
Echinococcus granulosus | follistatin | 0.00360767 | 0.473735 | 0.473735 |
Schistosoma mansoni | organic anion transporter | 0.00558431 | 1 | 1 |
Loa Loa (eye worm) | sodium-independent organic anion transporter | 0.00558431 | 1 | 1 |
Onchocerca volvulus | 0.00558431 | 1 | 1 | |
Brugia malayi | prostaglandin transporter | 0.00558431 | 1 | 1 |
Entamoeba histolytica | DEAD/DEAH box helicase, putative | 0.00182834 | 0 | 0.5 |
Toxoplasma gondii | transporter, major facilitator family protein | 0.00558431 | 1 | 1 |
Schistosoma mansoni | organic anion transporter | 0.00558431 | 1 | 1 |
Brugia malayi | Kazal-type serine protease inhibitor domain containing protein | 0.00360767 | 0.473735 | 0.473735 |
Loa Loa (eye worm) | hypothetical protein | 0.00558431 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00360767 | 0.473735 | 0.473735 |
Plasmodium falciparum | eukaryotic initiation factor 4A | 0.00182834 | 0 | 0.5 |
Toxoplasma gondii | Kazal-type serine protease inhibitor domain-containing protein | 0.00360767 | 0.473735 | 0.473735 |
Echinococcus multilocularis | organic anion transporting polypeptide 30B | 0.00558431 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.00558431 | 1 | 1 |
Onchocerca volvulus | 0.00360767 | 0.473735 | 0.473735 | |
Brugia malayi | Kazal-type serine protease inhibitor domain containing protein | 0.00360767 | 0.473735 | 0.473735 |
Brugia malayi | SPARC precursor | 0.00360767 | 0.473735 | 0.473735 |
Loa Loa (eye worm) | hypothetical protein | 0.00558431 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00360767 | 0.473735 | 0.473735 |
Giardia lamblia | Translation initiation factor eIF-4A, putative | 0.00182834 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antituberculosis activity against Mycobacterium tuberculosis H37Rv at 128 ug/mL | ChEMBL. | 17190449 | |
IC50 (functional) | = 13 ug ml-1 | Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 | ChEMBL. | 17190449 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 17190449 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.