Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0100701 | 0 | 0.5 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0100701 | 0 | 0.5 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0100701 | 0 | 0.5 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0100701 | 0 | 0.5 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0100701 | 0 | 0.5 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0100701 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0671724 | 0.777427 | 0.777427 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0100701 | 0 | 0.5 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0100701 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0100701 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0100701 | 0 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0100701 | 0 | 0.5 |
Schistosoma mansoni | coup transcription factor | 0.0100701 | 0 | 0.5 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0100701 | 0 | 0.5 |
Toxoplasma gondii | cytochrome p450 superfamily protein | 0.0761582 | 0.899766 | 1 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.0671724 | 0.777427 | 0.777427 |
Loa Loa (eye worm) | hypothetical protein | 0.0671724 | 0.777427 | 0.777427 |
Loa Loa (eye worm) | hypothetical protein | 0.0835204 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0100701 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0100701 | 0 | 0.5 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0100701 | 0 | 0.5 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0100701 | 0 | 0.5 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0100701 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0671724 | 0.777427 | 0.777427 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0100701 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 alpha | 0.0100701 | 0 | 0.5 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0100701 | 0 | 0.5 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0100701 | 0 | 0.5 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0100701 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0100701 | 0 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0100701 | 0 | 0.5 |
Brugia malayi | ecdysteroid receptor | 0.0835204 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0100701 | 0 | 0.5 |
Schistosoma mansoni | thyroid hormone receptor | 0.0100701 | 0 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0100701 | 0 | 0.5 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0100701 | 0 | 0.5 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0835204 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0100701 | 0 | 0.5 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0100701 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.9 ug ml-1 | Antichagasic activity against Trypanosoma cruzi | ChEMBL. | 18625560 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Trypanosoma cruzi | ChEMBL23 | 18625560 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.