Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon receptor | 477 aa | 457 aa | 25.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Carboxylesterase LipT | 0.005 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0295 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.042 | 0.042 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.042 | 0.042 |
Brugia malayi | Carboxylesterase family protein | 0.0295 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0295 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0295 | 1 | 1 |
Loa Loa (eye worm) | carboxylesterase | 0.0295 | 1 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0295 | 1 | 1 |
Onchocerca volvulus | 0.005 | 0 | 0.5 | |
Trichomonas vaginalis | carboxylesterase domain containing protein, putative | 0.005 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0295 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.005 | 0 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0295 | 1 | 1 |
Mycobacterium ulcerans | carboxylesterase, LipT | 0.005 | 0 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0295 | 1 | 1 |
Mycobacterium tuberculosis | POSSIBLE PARA-NITROBENZYL ESTERASE (FRAGMENT) | 0.005 | 0 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0295 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.042 | 0.042 |
Loa Loa (eye worm) | hypothetical protein | 0.0295 | 1 | 1 |
Onchocerca volvulus | 0.005 | 0 | 0.5 | |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.042 | 0.042 |
Trichomonas vaginalis | spcc417.12 protein, putative | 0.005 | 0 | 0.5 |
Onchocerca volvulus | 0.005 | 0 | 0.5 | |
Onchocerca volvulus | 0.005 | 0 | 0.5 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0295 | 1 | 1 |
Onchocerca volvulus | 0.005 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | Antagonist activity against human GCGR expressed in CHO cells assessed as glucagon-induced cAMP accumulation | ChEMBL. | 18539028 | |
IC50 (binding) | = 160 nM | Displacement of [125I]glucagon from human GCGR expressed in CHO cells | ChEMBL. | 18539028 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.