Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | signal transducer and activator of transcription 6, interleukin-4 induced | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | carbonic anhydrase II | 0.2153 | 0.107 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.0799 | 0.021 | 1 |
Mycobacterium tuberculosis | Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) | 0.5616 | 0.3269 | 0.3023 |
Mycobacterium tuberculosis | Probable conserved transmembrane protein | 0.3394 | 0.1858 | 0.1172 |
Leishmania major | carbonic anhydrase family protein, putative | 0.4209 | 0.2375 | 1 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 1.3995 | 0.8589 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.2153 | 0.107 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.2153 | 0.107 | 0.3971 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.4209 | 0.2375 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.2153 | 0.107 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.4209 | 0.2375 | 0.2375 |
Onchocerca volvulus | Putative sulfate transporter | 0.2938 | 0.1568 | 0.5 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.2153 | 0.107 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.4209 | 0.2375 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 1.6217 | 1 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 1.6217 | 1 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.2153 | 0.107 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0799 | 0.021 | 1 |
Echinococcus multilocularis | carbonic anhydrase II | 0.2153 | 0.107 | 1 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.4209 | 0.2375 | 1 |
Onchocerca volvulus | 0.2938 | 0.1568 | 0.5 | |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.2153 | 0.107 | 0.3971 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.2153 | 0.107 | 1 |
Chlamydia trachomatis | sulfate transporter | 0.0468 | 0 | 0.5 |
Plasmodium vivax | sulfate transporter, putative | 0.0468 | 0 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.2153 | 0.107 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.2153 | 0.107 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 22 nM | Inhibition of STAT6 activation in FW4 reporter cells | ChEMBL. | 18534856 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.